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Protein

Rhomboid-like protein 15

Gene

RBL15

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable rhomboid-type serine protease that catalyzes intramembrane proteolysis. May function in senescence.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei145NucleophileBy similarity1
Active sitei197Charge relay systemBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Names & Taxonomyi

Protein namesi
Recommended name:
Rhomboid-like protein 151 Publication (EC:3.4.21.-Curated)
Short name:
AtRBL151 Publication
Gene namesi
Name:RBL151 Publication
Synonyms:RBL111 Publication
Ordered Locus Names:At3g58460Imported
ORF Names:F14P22.50Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G58460

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei103 – 123HelicalSequence analysisAdd BLAST21
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002206071 – 403Rhomboid-like protein 15Add BLAST403

Proteomic databases

PaxDbiQ8LB17
PRIDEiQ8LB17

PTM databases

iPTMnetiQ8LB17

Expressioni

Gene expression databases

ExpressionAtlasiQ8LB17 baseline and differential
GenevisibleiQ8LB17 AT

Interactioni

Protein-protein interaction databases

BioGridi10330, 8 interactors
IntActiQ8LB17, 8 interactors
STRINGi3702.AT3G58460.2

Structurei

Secondary structure

1403
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi354 – 356Combined sources3
Helixi364 – 371Combined sources8
Turni372 – 374Combined sources3
Helixi377 – 387Combined sources11
Helixi391 – 399Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1VG5NMR-A342-401[»]
ProteinModelPortaliQ8LB17
SMRiQ8LB17
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8LB17

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini361 – 401UBAPROSITE-ProRule annotationAdd BLAST41

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 32Poly-Val4

Sequence similaritiesi

Belongs to the peptidase S54 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2632 Eukaryota
ENOG41100KJ LUCA
HOGENOMiHOG000070588
InParanoidiQ8LB17
PhylomeDBiQ8LB17

Family and domain databases

Gene3Di1.20.1540.10, 1 hit
InterProiView protein in InterPro
IPR022764 Peptidase_S54_rhomboid_dom
IPR035952 Rhomboid-like_sf
IPR015940 UBA
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF01694 Rhomboid, 1 hit
PF00627 UBA, 1 hit
SMARTiView protein in SMART
SM00165 UBA, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50030 UBA, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8LB17-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRPNIVTEAG VQTRVGQWWN AIPFLTSSVV VVCGVIYLIC LLTGYDTFYE
60 70 80 90 100
VCFLPSAIIS RFQVYRFYTA IIFHGSLLHV LFNMMALVPM GSELERIMGS
110 120 130 140 150
VRLLYLTVLL ATTNAVLHLL IASLAGYNPF YQYDHLMNEC AIGFSGILFS
160 170 180 190 200
MIVIETSLSG VTSRSVFGLF NVPAKLYPWI LLIVFQLLMT NVSLLGHLCG
210 220 230 240 250
ILSGFSYSYG LFNFLMPGSS FFTTIESASW MSSFIRRPKF IMCTGGNPSS
260 270 280 290 300
YIPTYSAQNT TSSGFSTGNA WRSLSSWLPQ REASNQSSED SRFPGRGRTL
310 320 330 340 350
STARDPTAPA GETDPNLHAR LLEDSSSPDR LSDATVNTVA DSRQAPIANA
360 370 380 390 400
AVLPQSQGRV AASEEQIQKL VAMGFDRTQV EVALAAADDD LTVAVEILMS

QQA
Length:403
Mass (Da):44,145
Last modified:August 30, 2005 - v2
Checksum:iFF6CD14E5582CB16
GO
Isoform 2 (identifier: Q8LB17-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     358-362: GRVAA → VTFLL
     363-403: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:362
Mass (Da):39,847
Checksum:iD4069D52D42ECAE2
GO

Sequence cautioni

The sequence CAB68184 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti237R → Q in AAM65024 (PubMed:14593172).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_057725358 – 362GRVAA → VTFLL in isoform 2. 5
Alternative sequenceiVSP_057726363 – 403Missing in isoform 2. Add BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137082 Genomic DNA Translation: CAB68184.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE79784.1
AY136386 mRNA Translation: AAM97052.1
BT000186 mRNA Translation: AAN15505.1
AK318905 mRNA Translation: BAH57020.1
AY087480 mRNA Translation: AAM65024.1
PIRiT45666
RefSeqiNP_567064.1, NM_115708.4 [Q8LB17-1]
UniGeneiAt.43287

Genome annotation databases

EnsemblPlantsiAT3G58460.1; AT3G58460.1; AT3G58460 [Q8LB17-1]
GeneIDi825015
GrameneiAT3G58460.1; AT3G58460.1; AT3G58460 [Q8LB17-1]
KEGGiath:AT3G58460

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBL15_ARATH
AccessioniPrimary (citable) accession number: Q8LB17
Secondary accession number(s): C0Z2U1, Q8L7A1, Q9M2H0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: August 30, 2005
Last modified: April 25, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health