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Protein

ADP,ATP carrier protein ER-ANT1

Gene

ER-ANT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the endoplasmic reticulum membrane.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei83ADPBy similarity1
Binding sitei95ADPBy similarity1
Binding sitei240ADPBy similarity1

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR

GO - Biological processi

  • adenine nucleotide transport Source: TAIR
  • regulation of mitochondrial membrane permeability Source: GO_Central
  • root development Source: TAIR
  • seed development Source: TAIR
  • shoot system development Source: TAIR

Keywordsi

Biological processTransport

Protein family/group databases

TCDBi2.A.29.1.6 the mitochondrial carrier (mc) family

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein ER-ANT1
Alternative name(s):
ADP/ATP translocase ER-ANT1
Endoplasmic reticulum-adenine nucleotide transporter 1
Short name:
ER-ANT1
Gene namesi
Name:ER-ANT1
Ordered Locus Names:At5g17400
ORF Names:T10B6_60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G17400
TAIRilocus:2178925 AT5G17400

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 37Helical; Name=1By similarityAdd BLAST28
Transmembranei78 – 102Helical; Name=2By similarityAdd BLAST25
Transmembranei111 – 131Helical; Name=3By similarityAdd BLAST21
Transmembranei181 – 202Helical; Name=4By similarityAdd BLAST22
Transmembranei216 – 236Helical; Name=5By similarityAdd BLAST21
Transmembranei276 – 296Helical; Name=6By similarityAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Dramatic growth retardation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004104731 – 306ADP,ATP carrier protein ER-ANT1Add BLAST306

Proteomic databases

PaxDbiQ8LB08
PRIDEiQ8LB08

Expressioni

Gene expression databases

ExpressionAtlasiQ8LB08 baseline and differential
GenevisibleiQ8LB08 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G17400.1

Structurei

3D structure databases

ProteinModelPortaliQ8LB08
SMRiQ8LB08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati8 – 101Solcar 1Add BLAST94
Repeati113 – 205Solcar 2Add BLAST93
Repeati213 – 299Solcar 3Add BLAST87

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni240 – 245Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi240 – 245Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
HOGENOMiHOG000165727
InParanoidiQ8LB08
KOiK05863
OMAiNGKRQFK
OrthoDBiEOG09360IJO

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q8LB08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIGKSERF SADFVMGGAA AIVAKSAAAP IERVKLLLQN QGEMIKTGHL
60 70 80 90 100
IRPYTGLGNC FTRIYREEGV LSFWRGNQAN VIRYFPTQAS NFAFKGYFKN
110 120 130 140 150
LLGCSKEKDG YLKWFAGNVA SGSAAGATTS LFLYHLDYAR TRLGTDAKEC
160 170 180 190 200
SVNGKRQFKG MIDVYRKTLS SDGIKGLYRG FGVSIVGITL YRGMYFGMYD
210 220 230 240 250
TIKPIVLVGS LEGNFLASFL LGWSITTSAG VIAYPFDTLR RRMMLTSGQP
260 270 280 290 300
VKYRNTIHAL REILKSEGFY ALYRGVTANM LLGVAGAGVL AGYDQLHQIA

YKHWVQ
Length:306
Mass (Da):33,788
Last modified:June 28, 2011 - v2
Checksum:i0D8615BD583B9B94
GO

Sequence cautioni

The sequence CAC01735 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391142 Genomic DNA Translation: CAC01735.1 Sequence problems.
CP002688 Genomic DNA Translation: AED92421.1
AY087494 mRNA Translation: AAM65037.1
PIRiT51577
RefSeqiNP_568345.1, NM_121746.4
UniGeneiAt.31555

Genome annotation databases

EnsemblPlantsiAT5G17400.1; AT5G17400.1; AT5G17400
GeneIDi831606
GrameneiAT5G17400.1; AT5G17400.1; AT5G17400
KEGGiath:AT5G17400

Similar proteinsi

Entry informationi

Entry nameiADT4_ARATH
AccessioniPrimary (citable) accession number: Q8LB08
Secondary accession number(s): F4KGZ7, Q9LF44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: May 23, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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