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Protein

ADP,ATP carrier protein ER-ANT1

Gene

ER-ANT1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the exchange of ADP and ATP across the endoplasmic reticulum membrane.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei83 – 831NucleotideBy similarity

GO - Molecular functioni

  • ATP:ADP antiporter activity Source: TAIR
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • adenine nucleotide transport Source: TAIR
  • ADP transport Source: GOC
  • ATP transport Source: GOC
  • root development Source: TAIR
  • seed development Source: TAIR
  • shoot system development Source: TAIR
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Protein family/group databases

TCDBi2.A.29.1.6. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP,ATP carrier protein ER-ANT1
Alternative name(s):
ADP/ATP translocase ER-ANT1
Endoplasmic reticulum-adenine nucleotide transporter 1
Short name:
ER-ANT1
Gene namesi
Name:ER-ANT1
Ordered Locus Names:At5g17400
ORF Names:T10B6_60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

TAIRiAT5G17400.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 4135Helical; Name=1By similarityAdd
BLAST
Transmembranei78 – 10225Helical; Name=2By similarityAdd
BLAST
Transmembranei111 – 14535Helical; Name=3By similarityAdd
BLAST
Transmembranei180 – 20728Helical; Name=4By similarityAdd
BLAST
Transmembranei212 – 24635Helical; Name=5By similarityAdd
BLAST
Transmembranei275 – 30026Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Disruption phenotypei

Dramatic growth retardation.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 306306ADP,ATP carrier protein ER-ANT1PRO_0000410473Add
BLAST

Proteomic databases

PaxDbiQ8LB08.
PRIDEiQ8LB08.

Expressioni

Gene expression databases

GenevisibleiQ8LB08. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi3702.AT5G17400.1.

Structurei

3D structure databases

ProteinModelPortaliQ8LB08.
SMRiQ8LB08. Positions 13-297.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati8 – 10194Solcar 1Add
BLAST
Repeati113 – 20593Solcar 2Add
BLAST
Repeati213 – 29987Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi240 – 2456Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiQ8LB08.
KOiK05863.
OMAiIMGITLY.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LB08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALIGKSERF SADFVMGGAA AIVAKSAAAP IERVKLLLQN QGEMIKTGHL
60 70 80 90 100
IRPYTGLGNC FTRIYREEGV LSFWRGNQAN VIRYFPTQAS NFAFKGYFKN
110 120 130 140 150
LLGCSKEKDG YLKWFAGNVA SGSAAGATTS LFLYHLDYAR TRLGTDAKEC
160 170 180 190 200
SVNGKRQFKG MIDVYRKTLS SDGIKGLYRG FGVSIVGITL YRGMYFGMYD
210 220 230 240 250
TIKPIVLVGS LEGNFLASFL LGWSITTSAG VIAYPFDTLR RRMMLTSGQP
260 270 280 290 300
VKYRNTIHAL REILKSEGFY ALYRGVTANM LLGVAGAGVL AGYDQLHQIA

YKHWVQ
Length:306
Mass (Da):33,788
Last modified:June 28, 2011 - v2
Checksum:i0D8615BD583B9B94
GO

Sequence cautioni

The sequence CAC01735.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391142 Genomic DNA. Translation: CAC01735.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92421.1.
AY087494 mRNA. Translation: AAM65037.1.
PIRiT51577.
RefSeqiNP_568345.1. NM_121746.3.
UniGeneiAt.31555.

Genome annotation databases

EnsemblPlantsiAT5G17400.1; AT5G17400.1; AT5G17400.
GeneIDi831606.
GrameneiAT5G17400.1; AT5G17400.1; AT5G17400.
KEGGiath:AT5G17400.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL391142 Genomic DNA. Translation: CAC01735.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED92421.1.
AY087494 mRNA. Translation: AAM65037.1.
PIRiT51577.
RefSeqiNP_568345.1. NM_121746.3.
UniGeneiAt.31555.

3D structure databases

ProteinModelPortaliQ8LB08.
SMRiQ8LB08. Positions 13-297.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT5G17400.1.

Protein family/group databases

TCDBi2.A.29.1.6. the mitochondrial carrier (mc) family.

Proteomic databases

PaxDbiQ8LB08.
PRIDEiQ8LB08.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT5G17400.1; AT5G17400.1; AT5G17400.
GeneIDi831606.
GrameneiAT5G17400.1; AT5G17400.1; AT5G17400.
KEGGiath:AT5G17400.

Organism-specific databases

TAIRiAT5G17400.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
HOGENOMiHOG000165727.
InParanoidiQ8LB08.
KOiK05863.
OMAiIMGITLY.

Enzyme and pathway databases

ReactomeiR-ATH-422356. Regulation of insulin secretion.

Miscellaneous databases

PROiQ8LB08.

Gene expression databases

GenevisibleiQ8LB08. AT.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The growing family of mitochondrial carriers in Arabidopsis."
    Picault N., Hodges M., Palmieri L., Palmieri F.
    Trends Plant Sci. 9:138-146(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.
  5. "Identification of a novel adenine nucleotide transporter in the endoplasmic reticulum of Arabidopsis."
    Leroch M., Neuhaus H.E., Kirchberger S., Zimmermann S., Melzer M., Gerhold J., Tjaden J.
    Plant Cell 20:438-451(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiADT4_ARATH
AccessioniPrimary (citable) accession number: Q8LB08
Secondary accession number(s): F4KGZ7, Q9LF44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 28, 2011
Last sequence update: June 28, 2011
Last modified: February 17, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. At least 2 of the odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.