SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8LB02

- SDHB2_ARATH

UniProt

Q8LB02 - SDHB2_ARATH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial
Gene
SDH2-2, At5g40650, MNF13.170, MNF13.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster By similarity.
Binds 1 3Fe-4S cluster By similarity.
Binds 1 4Fe-4S cluster By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi106 – 1061Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi109 – 1091Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi121 – 1211Iron-sulfur 1 (2Fe-2S) By similarity
Metal bindingi193 – 1931Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi196 – 1961Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi199 – 1991Iron-sulfur 2 (4Fe-4S) By similarity
Metal bindingi203 – 2031Iron-sulfur 3 (3Fe-4S) By similarity
Binding sitei208 – 2081Ubiquinone; shared with DHSD By similarity
Metal bindingi250 – 2501Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi256 – 2561Iron-sulfur 3 (3Fe-4S) By similarity
Metal bindingi260 – 2601Iron-sulfur 2 (4Fe-4S) By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB-KW
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  4. electron carrier activity Source: TAIR
  5. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  6. succinate dehydrogenase activity Source: TAIR
  7. zinc ion binding Source: TAIR
Complete GO annotation...

GO - Biological processi

  1. mitochondrial electron transport, succinate to ubiquinone Source: TAIR
  2. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

BioCyciMetaCyc:AT5G40650-MONOMER.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:SDH2-2
Ordered Locus Names:At5g40650
ORF Names:MNF13.170, MNF13.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G40650.

Subcellular locationi

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side 1 Publication

GO - Cellular componenti

  1. mitochondrial respiratory chain complex II Source: TAIR
  2. mitochondrion Source: TAIR
  3. succinate dehydrogenase complex Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2828Mitochondrion Reviewed prediction
Add
BLAST
Chaini29 – 280252Succinate dehydrogenase [ubiquinone] iron-sulfur subunit 2, mitochondrial
PRO_0000247596Add
BLAST

Proteomic databases

PaxDbiQ8LB02.
PRIDEiQ8LB02.

Expressioni

Tissue specificityi

Ubiquitous. Preferentially expressed in flowers, inflorescences and root tips.3 Publications

Developmental stagei

Expressed in floral meristems and sex organ primordia at early stages of development. Later expressed in anthers, particularly in the tapetum, pollen mother cells, and microspores.1 Publication

Gene expression databases

GenevestigatoriQ8LB02.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit By similarity.1 Publication

Protein-protein interaction databases

IntActiQ8LB02. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8LB02.
SMRiQ8LB02. Positions 46-279.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 140902Fe-2S ferredoxin-type
Add
BLAST
Domaini183 – 213314Fe-4S ferredoxin-type
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
HOGENOMiHOG000160590.
InParanoidiQ8LB02.
KOiK00235.
OMAiIMNCSRT.
PhylomeDBiQ8LB02.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LB02-1 [UniParc]FASTAAdd to Basket

« Hide

MAFGLIGRVV GTKSSRLSTA ARLIPARWTS TGSEAQSKAS TGGGGASLKT    50
FQIYRWNPDN PGKPELQDYK IDLKDCGPMV LDALIKIKNE MDPSLTFRRS 100
CREGICGSCA MNIDGCNGLA CLTKIESGSK ETTITPLPHM FVIKDLVVDM 150
TNFYNQYKSI EPWLKRKNPA SVPGKEILQS KKDRAKLDGM YECILCACCS 200
TSCPSYWWNP ESYLGPAALL HANRWISDSR DEYTKERLEA IDDEFKLYRC 250
HTILNCARAC PKGLNPGKQI THIKQLQKSG 280
Length:280
Mass (Da):31,141
Last modified:July 25, 2006 - v2
Checksum:i1F505A8C7D68DACD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti14 – 141S → P in CAC19856. 1 Publication
Sequence conflicti14 – 141S → P in AAM65047. 1 Publication
Sequence conflicti31 – 311T → K in CAC19856. 1 Publication
Sequence conflicti31 – 311T → K in AAM65047. 1 Publication
Sequence conflicti127 – 1271S → F in CAC19856. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278911 mRNA. Translation: CAC19856.1.
AB009052 Genomic DNA. Translation: BAB08537.1.
CP002688 Genomic DNA. Translation: AED94578.1.
AY074299 mRNA. Translation: AAL66996.1.
AY123036 mRNA. Translation: AAM67569.1.
AY087504 mRNA. Translation: AAM65047.1.
RefSeqiNP_198881.1. NM_123430.1.
UniGeneiAt.20145.
At.67187.
At.7421.

Genome annotation databases

EnsemblPlantsiAT5G40650.1; AT5G40650.1; AT5G40650.
GeneIDi834065.
KEGGiath:AT5G40650.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ278911 mRNA. Translation: CAC19856.1 .
AB009052 Genomic DNA. Translation: BAB08537.1 .
CP002688 Genomic DNA. Translation: AED94578.1 .
AY074299 mRNA. Translation: AAL66996.1 .
AY123036 mRNA. Translation: AAM67569.1 .
AY087504 mRNA. Translation: AAM65047.1 .
RefSeqi NP_198881.1. NM_123430.1.
UniGenei At.20145.
At.67187.
At.7421.

3D structure databases

ProteinModelPortali Q8LB02.
SMRi Q8LB02. Positions 46-279.
ModBasei Search...

Protein-protein interaction databases

IntActi Q8LB02. 1 interaction.

Proteomic databases

PaxDbi Q8LB02.
PRIDEi Q8LB02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G40650.1 ; AT5G40650.1 ; AT5G40650 .
GeneIDi 834065.
KEGGi ath:AT5G40650.

Organism-specific databases

GeneFarmi 2169. 175.
TAIRi AT5G40650.

Phylogenomic databases

eggNOGi COG0479.
HOGENOMi HOG000160590.
InParanoidi Q8LB02.
KOi K00235.
OMAi IMNCSRT.
PhylomeDBi Q8LB02.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .
BioCyci MetaCyc:AT5G40650-MONOMER.

Gene expression databases

Genevestigatori Q8LB02.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Three different genes encode the iron-sulphur subunit of succinate dehydrogenase in Arabidopsis thaliana."
    Figueroa P., Leon G., Elorza A., Holuigue L., Jordana X.
    Plant Mol. Biol. 46:241-250(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: cv. Columbia.
  2. "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence features of the regions of 1,456,315 bp covered by nineteen physically assigned P1 and TAC clones."
    Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N., Tabata S.
    DNA Res. 5:41-54(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The four subunits of mitochondrial respiratory complex II are encoded by multiple nuclear genes and targeted to mitochondria in Arabidopsis thaliana."
    Figueroa P., Leon G., Elorza A., Holuigue L., Araya A., Jordana X.
    Plant Mol. Biol. 50:725-734(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT, TISSUE SPECIFICITY.
  7. "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins."
    Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H.
    Plant Cell 16:241-256(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Strain: cv. Landsberg erecta.
  8. "Nuclear SDH2-1 and SDH2-2 genes, encoding the iron-sulfur subunit of mitochondrial complex II in Arabidopsis, have distinct cell-specific expression patterns and promoter activities."
    Elorza A., Leon G., Gomez I., Mouras A., Holuigue L., Araya A., Jordana X.
    Plant Physiol. 136:4072-4087(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSDHB2_ARATH
AccessioniPrimary (citable) accession number: Q8LB02
Secondary accession number(s): Q9FM32, Q9G3L9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: July 25, 2006
Last modified: May 14, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi