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Q8LAY8

- P2C69_ARATH

UniProt

Q8LAY8 - P2C69_ARATH

Protein

Probable protein phosphatase 2C 69

Gene

At5g10740

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi69 – 691Manganese 1By similarity
    Metal bindingi69 – 691Manganese 2By similarity
    Metal bindingi70 – 701Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi231 – 2311Manganese 2By similarity
    Metal bindingi270 – 2701Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT5G10740-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 69 (EC:3.1.3.16)
    Short name:
    AtPP2C69
    Gene namesi
    Ordered Locus Names:At5g10740
    ORF Names:MAJ23.3, T30N20.10
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G10740.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Probable protein phosphatase 2C 69PRO_0000367990Add
    BLAST

    Proteomic databases

    PaxDbiQ8LAY8.
    PRIDEiQ8LAY8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8LAY8.

    Interactioni

    Protein-protein interaction databases

    BioGridi16219. 1 interaction.
    IntActiQ8LAY8. 1 interaction.
    MINTiMINT-8390682.
    STRINGi3702.AT5G10740.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8LAY8.
    SMRiQ8LAY8. Positions 34-277.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 272213PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ8LAY8.
    KOiK17506.
    OMAiEMPPLGD.
    PhylomeDBiQ8LAY8.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8LAY8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGYLDLALSY SNQPQTVEAP ASGGGLSQNG KFSYGYASSA GKRSSMEDFF    50
    ETRIDGINGE IVGLFGVFDG HGGARAAEYV KRHLFSNLIT HPKFISDTKS 100
    AITDAYNHTD SELLKSENSH NRDAGSTAST AILVGDRLVV ANVGDSRAVI 150
    SRGGKAIAVS RDHKPDQSDE RERIENAGGF VMWAGTWRVG GVLAVSRAFG 200
    DRLLKQYVVA DPEIQEEKID DTLEFLILAS DGLWDVFSNE AAVAMVKEVE 250
    DPEDSAKKLV GEAIKRGSAD NITCVVVRFL EKKSASSSHI SSSSSKEAKE 300
    MPPLGDLAIS SNEAKQVQIG SGNKPENVTN RKPDTASRST DTLTLERNSV 350
    TDKV 354
    Length:354
    Mass (Da):38,036
    Last modified:October 1, 2002 - v1
    Checksum:i87DA535B561C9D68
    GO

    Sequence cautioni

    The sequence CAB96829.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365234 Genomic DNA. Translation: CAB96829.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED91590.1.
    AK117549 mRNA. Translation: BAC42210.1.
    BT005431 mRNA. Translation: AAO63851.1.
    AY087522 mRNA. Translation: AAM65064.1.
    PIRiT50783.
    RefSeqiNP_568237.1. NM_121112.4.
    UniGeneiAt.44878.

    Genome annotation databases

    EnsemblPlantsiAT5G10740.1; AT5G10740.1; AT5G10740.
    GeneIDi830941.
    KEGGiath:AT5G10740.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL365234 Genomic DNA. Translation: CAB96829.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED91590.1 .
    AK117549 mRNA. Translation: BAC42210.1 .
    BT005431 mRNA. Translation: AAO63851.1 .
    AY087522 mRNA. Translation: AAM65064.1 .
    PIRi T50783.
    RefSeqi NP_568237.1. NM_121112.4.
    UniGenei At.44878.

    3D structure databases

    ProteinModelPortali Q8LAY8.
    SMRi Q8LAY8. Positions 34-277.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 16219. 1 interaction.
    IntActi Q8LAY8. 1 interaction.
    MINTi MINT-8390682.
    STRINGi 3702.AT5G10740.1-P.

    Proteomic databases

    PaxDbi Q8LAY8.
    PRIDEi Q8LAY8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G10740.1 ; AT5G10740.1 ; AT5G10740 .
    GeneIDi 830941.
    KEGGi ath:AT5G10740.

    Organism-specific databases

    TAIRi AT5G10740.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q8LAY8.
    KOi K17506.
    OMAi EMPPLGD.
    PhylomeDBi Q8LAY8.

    Enzyme and pathway databases

    BioCyci ARA:AT5G10740-MONOMER.

    Gene expression databases

    Genevestigatori Q8LAY8.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
      Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
      , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
      Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C69_ARATH
    AccessioniPrimary (citable) accession number: Q8LAY8
    Secondary accession number(s): Q9LEW5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3