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Q8LAY8

- P2C69_ARATH

UniProt

Q8LAY8 - P2C69_ARATH

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Protein
Probable protein phosphatase 2C 69
Gene
At5g10740, MAJ23.3, T30N20.10
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 magnesium or manganese ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi69 – 691Manganese 1 By similarity
Metal bindingi69 – 691Manganese 2 By similarity
Metal bindingi70 – 701Manganese 1; via carbonyl oxygen By similarity
Metal bindingi231 – 2311Manganese 2 By similarity
Metal bindingi270 – 2701Manganese 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT5G10740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 69 (EC:3.1.3.16)
Short name:
AtPP2C69
Gene namesi
Ordered Locus Names:At5g10740
ORF Names:MAJ23.3, T30N20.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G10740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Probable protein phosphatase 2C 69
PRO_0000367990Add
BLAST

Proteomic databases

PaxDbiQ8LAY8.
PRIDEiQ8LAY8.

Expressioni

Gene expression databases

GenevestigatoriQ8LAY8.

Interactioni

Protein-protein interaction databases

BioGridi16219. 1 interaction.
IntActiQ8LAY8. 1 interaction.
MINTiMINT-8390682.
STRINGi3702.AT5G10740.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8LAY8.
SMRiQ8LAY8. Positions 34-277.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 272213PP2C-like
Add
BLAST

Sequence similaritiesi

Belongs to the PP2C family.
Contains 1 PP2C-like domain.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ8LAY8.
KOiK17506.
OMAiEMPPLGD.
PhylomeDBiQ8LAY8.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8LAY8-1 [UniParc]FASTAAdd to Basket

« Hide

MGYLDLALSY SNQPQTVEAP ASGGGLSQNG KFSYGYASSA GKRSSMEDFF    50
ETRIDGINGE IVGLFGVFDG HGGARAAEYV KRHLFSNLIT HPKFISDTKS 100
AITDAYNHTD SELLKSENSH NRDAGSTAST AILVGDRLVV ANVGDSRAVI 150
SRGGKAIAVS RDHKPDQSDE RERIENAGGF VMWAGTWRVG GVLAVSRAFG 200
DRLLKQYVVA DPEIQEEKID DTLEFLILAS DGLWDVFSNE AAVAMVKEVE 250
DPEDSAKKLV GEAIKRGSAD NITCVVVRFL EKKSASSSHI SSSSSKEAKE 300
MPPLGDLAIS SNEAKQVQIG SGNKPENVTN RKPDTASRST DTLTLERNSV 350
TDKV 354
Length:354
Mass (Da):38,036
Last modified:October 1, 2002 - v1
Checksum:i87DA535B561C9D68
GO

Sequence cautioni

The sequence CAB96829.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL365234 Genomic DNA. Translation: CAB96829.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED91590.1.
AK117549 mRNA. Translation: BAC42210.1.
BT005431 mRNA. Translation: AAO63851.1.
AY087522 mRNA. Translation: AAM65064.1.
PIRiT50783.
RefSeqiNP_568237.1. NM_121112.4.
UniGeneiAt.44878.

Genome annotation databases

EnsemblPlantsiAT5G10740.1; AT5G10740.1; AT5G10740.
GeneIDi830941.
KEGGiath:AT5G10740.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL365234 Genomic DNA. Translation: CAB96829.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED91590.1 .
AK117549 mRNA. Translation: BAC42210.1 .
BT005431 mRNA. Translation: AAO63851.1 .
AY087522 mRNA. Translation: AAM65064.1 .
PIRi T50783.
RefSeqi NP_568237.1. NM_121112.4.
UniGenei At.44878.

3D structure databases

ProteinModelPortali Q8LAY8.
SMRi Q8LAY8. Positions 34-277.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 16219. 1 interaction.
IntActi Q8LAY8. 1 interaction.
MINTi MINT-8390682.
STRINGi 3702.AT5G10740.1-P.

Proteomic databases

PaxDbi Q8LAY8.
PRIDEi Q8LAY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G10740.1 ; AT5G10740.1 ; AT5G10740 .
GeneIDi 830941.
KEGGi ath:AT5G10740.

Organism-specific databases

TAIRi AT5G10740.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q8LAY8.
KOi K17506.
OMAi EMPPLGD.
PhylomeDBi Q8LAY8.

Enzyme and pathway databases

BioCyci ARA:AT5G10740-MONOMER.

Gene expression databases

Genevestigatori Q8LAY8.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana."
    Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E., Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.
    , Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A., Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I., Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T., Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.
    Nature 408:823-826(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C69_ARATH
AccessioniPrimary (citable) accession number: Q8LAY8
Secondary accession number(s): Q9LEW5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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