Q8LAH8 (NDK4_ARATH) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 80.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial Short name=NDK IV Short name=NDP kinase IV Short name=NDPK IV EC=2.7.4.6 Alternative name(s): Nucleoside diphosphate kinase 4 | ||||||
| Gene names |
| ||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) | ||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Protein attributes
| Sequence length | 237 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Shows the highest specificity towards GDP By similarity. |
| Catalytic activity | ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. |
| Cofactor | Magnesium By similarity. |
| Subunit structure | Homohexamer Probable. |
| Subcellular location | Plastid › chloroplast thylakoid lumen By similarity. Mitochondrion intermembrane space By similarity Ref.6 Ref.7. |
| Sequence similarities | Belongs to the NDK family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 84 | 84 | Chloroplast and mitochondrion By similarity | ||||||
| Chain | 85 – 237 | 153 | Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial | PRO_0000019436 | |||||
Sites | |||||||||
| Active site | 201 | 1 | Pros-phosphohistidine intermediate By similarity | ||||||
| Binding site | 95 | 1 | ATP By similarity | ||||||
| Binding site | 143 | 1 | ATP By similarity | ||||||
| Binding site | 171 | 1 | ATP By similarity | ||||||
| Binding site | 177 | 1 | ATP By similarity | ||||||
| Binding site | 188 | 1 | ATP By similarity | ||||||
| Binding site | 198 | 1 | ATP By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 36 | 1 | S → T in AAM65336. Ref.5 | ||||||
| Sequence conflict | 66 | 1 | G → R in AAM65336. Ref.5 | ||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Arabidopsis NDP kinase gene NDK4." Yabe N., Hashimoto K., Hasunuma K. Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Columbia. |
| [2] | "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. McCombie W.R.Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [3] | The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia. |
| [4] | "Functional annotation of a full-length Arabidopsis cDNA collection." Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K. Science 296:141-145(2002) [PubMed: 11910074] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "Proteomic approach to identify novel mitochondrial proteins in Arabidopsis." Kruft V., Eubel H., Jaensch L., Werhahn W., Braun H.-P. Plant Physiol. 127:1694-1710(2001) [PubMed: 11743114] [Abstract] Cited for: PROTEIN SEQUENCE OF 85-102, SUBCELLULAR LOCATION. Tissue: Leaf and Stem. |
| [7] | "Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins." Heazlewood J.L., Tonti-Filippini J.S., Gout A.M., Day D.A., Whelan J., Millar A.H. Plant Cell 16:241-256(2004) [PubMed: 14671022] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]. Strain: cv. Landsberg erecta. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AL078468 Genomic DNA. Translation: CAB43890.1. AL161560 Genomic DNA. Translation: CAB81308.1. CP002687 Genomic DNA. Translation: AEE84824.1. AB044970 Genomic DNA. Translation: BAB19789.1. AK117895 mRNA. Translation: BAC42534.1. AY087800 mRNA. Translation: AAM65336.1. |
| IPI | IPI00542543. |
| PIR | T08909. |
| RefSeq | NP_567690.1. NM_118522.3. |
| UniGene | At.32397. |
3D structure databases | |
| ProteinModelPortal | Q8LAH8. |
| SMR | Q8LAH8. Positions 85-235. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8LAH8. |
Proteomic databases | |
| PRIDE | Q8LAH8. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblPlants | AT4G23900.1; AT4G23900.1; AT4G23900. |
| GeneID | 828490. |
| GenomeReviews | Gene locus AT4G23900 in contig CT486007_GR. |
| KEGG | ath:AT4G23900. |
| NMPDR | fig|3702.1.peg.20272. |
Organism-specific databases | |
| GeneFarm | 1972. 147. |
| TAIR | At4g23900. |
Phylogenomic databases | |
| GeneTree | EPGT00070000029876. |
| HOGENOM | HBG445152. |
| InParanoid | Q8LAH8. |
| OMA | DEINLWF. |
| PhylomeDB | Q8LAH8. |
| ProtClustDB | PLN02619. |
Gene expression databases | |
| ArrayExpress | Q8LAH8. |
| Genevestigator | Q8LAH8. |
| GermOnline | AT4G23900. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR001564. Nucleoside_diP_kinase. IPR023005. Nucleoside_diP_kinase_AS. [Graphical view] |
| Gene3D | G3DSA:3.30.70.141. NDK. 1 hit. |
| KO | K00940. |
| PANTHER | PTHR11349. Nuc_diP_kinase_core. 1 hit. |
| Pfam | PF00334. NDK. 1 hit. [Graphical view] |
| PRINTS | PR01243. NUCDPKINASE. |
| SMART | SM00562. NDK. 1 hit. [Graphical view] |
| SUPFAM | SSF54919. NDK. 1 hit. |
| PROSITE | PS00469. NDP_KINASES. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | NDK4_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q8LAH8 Secondary accession number(s): Q9T0A5 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Plant Protein Annotation Program | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

Clusters with