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Protein

Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial

Gene

NDK4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Shows the highest specificity towards GDP (By similarity).By similarity

Catalytic activityi

ATP + nucleoside diphosphate = ADP + nucleoside triphosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95ATPBy similarity1
Binding sitei143ATPBy similarity1
Binding sitei171ATPBy similarity1
Binding sitei177ATPBy similarity1
Binding sitei188ATPBy similarity1
Binding sitei198ATPBy similarity1
Active sitei201Pros-phosphohistidine intermediateBy similarity1

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • nucleoside diphosphate kinase activity Source: GO_Central
  • zinc ion binding Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processNucleotide metabolism
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT4G23900-MONOMER
ReactomeiR-ATH-499943 Interconversion of nucleotide di- and triphosphates
R-ATH-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleoside diphosphate kinase IV, chloroplastic/mitochondrial (EC:2.7.4.6)
Short name:
NDK IV
Short name:
NDP kinase IV
Short name:
NDPK IV
Alternative name(s):
Nucleoside diphosphate kinase 4
Gene namesi
Name:NDK4
Ordered Locus Names:At4g23900
ORF Names:T32A16.70
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G23900
TAIRilocus:2138101 AT4G23900

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Mitochondrion, Plastid, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 84Chloroplast and mitochondrionBy similarityAdd BLAST84
ChainiPRO_000001943685 – 237Nucleoside diphosphate kinase IV, chloroplastic/mitochondrialAdd BLAST153

Proteomic databases

PaxDbiQ8LAH8
PRIDEiQ8LAH8

PTM databases

iPTMnetiQ8LAH8

Expressioni

Gene expression databases

ExpressionAtlasiQ8LAH8 baseline and differential
GenevisibleiQ8LAH8 AT

Interactioni

Subunit structurei

Homohexamer.Curated

Protein-protein interaction databases

STRINGi3702.AT4G23900.1

Structurei

3D structure databases

ProteinModelPortaliQ8LAH8
SMRiQ8LAH8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NDK family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0888 Eukaryota
COG0105 LUCA
HOGENOMiHOG000224564
InParanoidiQ8LAH8
KOiK00940
OrthoDBiEOG09360LYS
PhylomeDBiQ8LAH8

Family and domain databases

Gene3Di3.30.70.141, 1 hit
HAMAPiMF_00451 NDP_kinase, 1 hit
InterProiView protein in InterPro
IPR034907 NDK-like_dom
IPR036850 NDK-like_dom_sf
IPR001564 Nucleoside_diP_kinase
IPR023005 Nucleoside_diP_kinase_AS
PfamiView protein in Pfam
PF00334 NDK, 1 hit
PRINTSiPR01243 NUCDPKINASE
SMARTiView protein in SMART
SM00562 NDK, 1 hit
SUPFAMiSSF54919 SSF54919, 1 hit
PROSITEiView protein in PROSITE
PS00469 NDP_KINASES, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8LAH8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSQICRSAS RAARSLLSSA KNARFFSEGR AIGAASVVHA TGKVPQYASN
60 70 80 90 100
FGKSGSGFVS NSWITGLLAL PAAAFMLQDQ EALAAEMERT FIAIKPDGVQ
110 120 130 140 150
RGLISEIITR FERKGYKLVG IKVMVPSKGF AQKHYHDLKE RPFFNGLCNF
160 170 180 190 200
LSSGPVVAMV WEGEGVIRYG RKLIGATDPQ KSEPGTIRGD LAVVVGRNII
210 220 230
HGSDGPETAK DEISLWFKPE ELVSYTSNAE KWIYGQN
Length:237
Mass (Da):25,773
Last modified:March 15, 2004 - v2
Checksum:i0CC2B487E3D376FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36S → T in AAM65336 (Ref. 5) Curated1
Sequence conflicti66G → R in AAM65336 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078468 Genomic DNA Translation: CAB43890.1
AL161560 Genomic DNA Translation: CAB81308.1
CP002687 Genomic DNA Translation: AEE84824.1
AB044970 Genomic DNA Translation: BAB19789.1
AK117895 mRNA Translation: BAC42534.1
AY087800 mRNA Translation: AAM65336.1
PIRiT08909
RefSeqiNP_567690.1, NM_118522.3
UniGeneiAt.32397

Genome annotation databases

EnsemblPlantsiAT4G23900.1; AT4G23900.1; AT4G23900
GeneIDi828490
GrameneiAT4G23900.1; AT4G23900.1; AT4G23900
KEGGiath:AT4G23900

Similar proteinsi

Entry informationi

Entry nameiNDK4_ARATH
AccessioniPrimary (citable) accession number: Q8LAH8
Secondary accession number(s): Q9T0A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: March 15, 2004
Last modified: April 25, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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