Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 4-phosphate 5-kinase 9

Gene

PIP5K9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in sugar-mediated root development. Interaction with CINV1 induces repression of CINV1 activity and negative regulation of sugar-mediated root cell elongation.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: TAIR
  • cellular amino acid metabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G09920-MONOMER.
BRENDAi2.7.1.68. 399.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 9 (EC:2.7.1.68)
Short name:
AtPIP5K9
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 9
Diphosphoinositide kinase 9
PtdIns(4)P-5-kinase 9
Gene namesi
Name:PIP5K9
Ordered Locus Names:At3g09920
ORF Names:F8A24.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G09920.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • membrane Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854811 – 815Phosphatidylinositol 4-phosphate 5-kinase 9Add BLAST815

Proteomic databases

PaxDbiQ8L850.
PRIDEiQ8L850.

PTM databases

iPTMnetiQ8L850.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

Transiently down-regulated by cold.1 Publication

Gene expression databases

GenevisibleiQ8L850. AT.

Interactioni

Subunit structurei

Interacts with CINV1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CINV1Q9LQF26EBI-2008013,EBI-2008033

Protein-protein interaction databases

BioGridi5485. 1 interactor.
IntActiQ8L850. 1 interactor.
STRINGi3702.AT3G09920.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L850.
SMRiQ8L850.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 80MORN 1Add BLAST23
Repeati81 – 103MORN 2Add BLAST23
Repeati104 – 126MORN 3Add BLAST23
Repeati127 – 149MORN 4Add BLAST23
Repeati150 – 172MORN 5Add BLAST23
Repeati173 – 195MORN 6Add BLAST23
Repeati196 – 218MORN 7Add BLAST23
Repeati219 – 240MORN 8Add BLAST22
Domaini391 – 809PIPKPROSITE-ProRule annotationAdd BLAST419

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni769 – 790Activation loopBy similarityAdd BLAST22

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ8L850.
KOiK00889.
OMAiVFEGSWI.
OrthoDBiEOG0936025Q.
PhylomeDBiQ8L850.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8L850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLDVRGAV SFAERTKSVD ALTKKEILSA LNSGEVSETS EDARFRVREL
60 70 80 90 100
VLPDGESYSG SLLGNVPEGP GKYIWSDGCV YDGEWRRGMR HGIGNMRWAS
110 120 130 140 150
GASYDGEFSG GYMHGSGTYV DANKLTYKGR WRLNLKHGLG YQVYPNGDVF
160 170 180 190 200
EGSWIQGLGE GPGKYTWANK NVYLGDMKGG KMSGKGTLTW VTGDSYEGSW
210 220 230 240 250
LNGMMHGVGV YTWSDGGCYV GTWTRGLKDG KGSFYSAGTR VPVVQEFYLN
260 270 280 290 300
ALRKRGVLPD MRRQNQVASS VNMENLRVGV NRNKLSKGSL INLEQSRNGR
310 320 330 340 350
VSLERRWSLE VSIEKVIGHG YSDLSTAVLD SGSSVQYKAN IPILEREYMQ
360 370 380 390 400
GVLISELVVN NGFSRTSRRA KRKHKRLVKE AKKPGEVVIK GHRSYDLMLS
410 420 430 440 450
LQLGIRYTVG KITPIQRRQV RTADFGPRAS FWMTFPRAGS TMTPPHHSED
460 470 480 490 500
FKWKDYCPMV FRNLREMFKI DAADYMMSIC GNDTLRELSS PGKSGSVFFL
510 520 530 540 550
SQDDRFMIKT LRKSEVKVLL RMLPDYHHHV KTYENTLITK FFGLHRIKPS
560 570 580 590 600
SGQKFRFVVM GNMFFTDLRI HRRFDLKGSS LGRSADKVEI DENTILKDLD
610 620 630 640 650
LNYSFFLETS WREGLLRQLE IDSKFLEAQN IMDYSLLLGV HHRAPQHLRS
660 670 680 690 700
QLVRSQSITT DALESVAEDD TIEDDMLSYH EGLVLVPRGS ENTVTGPHIR
710 720 730 740 750
GSRLRASAVG DEEVDLLLPG TARLQIQQGV NMPARAELIP GREDKEKQIL
760 770 780 790 800
HDCCDVVLYL GIIDILQEYN MTKKIEHAYK SLHFDSLSIS AVDPTFYSQR
810
FLEFIKKVFP QNNKS
Length:815
Mass (Da):92,092
Last modified:October 25, 2005 - v2
Checksum:i3194F009D2C50130
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti482N → K in AAM53300 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ810853 mRNA. Translation: CAH18644.1.
AC015985 Genomic DNA. Translation: AAF23244.1.
CP002686 Genomic DNA. Translation: AEE74832.1.
CP002686 Genomic DNA. Translation: AEE74833.1.
CP002686 Genomic DNA. Translation: AEE74834.1.
AY120742 mRNA. Translation: AAM53300.1.
AK229815 mRNA. Translation: BAF01646.1.
RefSeqiNP_001030666.1. NM_001035589.3.
NP_001189852.1. NM_001202923.1.
NP_187603.1. NM_111827.3.
UniGeneiAt.40019.

Genome annotation databases

EnsemblPlantsiAT3G09920.1; AT3G09920.1; AT3G09920.
AT3G09920.2; AT3G09920.2; AT3G09920.
AT3G09920.3; AT3G09920.3; AT3G09920.
GeneIDi820151.
GrameneiAT3G09920.1; AT3G09920.1; AT3G09920.
AT3G09920.2; AT3G09920.2; AT3G09920.
AT3G09920.3; AT3G09920.3; AT3G09920.
KEGGiath:AT3G09920.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ810853 mRNA. Translation: CAH18644.1.
AC015985 Genomic DNA. Translation: AAF23244.1.
CP002686 Genomic DNA. Translation: AEE74832.1.
CP002686 Genomic DNA. Translation: AEE74833.1.
CP002686 Genomic DNA. Translation: AEE74834.1.
AY120742 mRNA. Translation: AAM53300.1.
AK229815 mRNA. Translation: BAF01646.1.
RefSeqiNP_001030666.1. NM_001035589.3.
NP_001189852.1. NM_001202923.1.
NP_187603.1. NM_111827.3.
UniGeneiAt.40019.

3D structure databases

ProteinModelPortaliQ8L850.
SMRiQ8L850.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi5485. 1 interactor.
IntActiQ8L850. 1 interactor.
STRINGi3702.AT3G09920.1.

PTM databases

iPTMnetiQ8L850.

Proteomic databases

PaxDbiQ8L850.
PRIDEiQ8L850.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G09920.1; AT3G09920.1; AT3G09920.
AT3G09920.2; AT3G09920.2; AT3G09920.
AT3G09920.3; AT3G09920.3; AT3G09920.
GeneIDi820151.
GrameneiAT3G09920.1; AT3G09920.1; AT3G09920.
AT3G09920.2; AT3G09920.2; AT3G09920.
AT3G09920.3; AT3G09920.3; AT3G09920.
KEGGiath:AT3G09920.

Organism-specific databases

TAIRiAT3G09920.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ8L850.
KOiK00889.
OMAiVFEGSWI.
OrthoDBiEOG0936025Q.
PhylomeDBiQ8L850.

Enzyme and pathway databases

BioCyciARA:AT3G09920-MONOMER.
BRENDAi2.7.1.68. 399.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ8L850.

Gene expression databases

GenevisibleiQ8L850. AT.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 2 hits.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 8 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K9_ARATH
AccessioniPrimary (citable) accession number: Q8L850
Secondary accession number(s): Q0WMK5, Q9SF93
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: November 30, 2016
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

The gain-of-function mutant pip5k9-d (T-DNA insertion line) has reduced primary root length.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.