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Protein

Phosphatidylinositol 4-phosphate 5-kinase 9

Gene

PIP5K9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in sugar-mediated root development. Interaction with CINV1 induces repression of CINV1 activity and negative regulation of sugar-mediated root cell elongation.1 Publication

Miscellaneous

The gain-of-function mutant pip5k9-d (T-DNA insertion line) has reduced primary root length.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: TAIR
  • cellular amino acid metabolic process Source: TAIR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G09920-MONOMER
BRENDAi2.7.1.68 399
ReactomeiR-ATH-1660499 Synthesis of PIPs at the plasma membrane
R-ATH-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-ATH-8856828 Clathrin-mediated endocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 9 (EC:2.7.1.68)
Short name:
AtPIP5K9
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 9
Diphosphoinositide kinase 9
PtdIns(4)P-5-kinase 9
Gene namesi
Name:PIP5K9
Ordered Locus Names:At3g09920
ORF Names:F8A24.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09920
TAIRilocus:2085074 AT3G09920

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854811 – 815Phosphatidylinositol 4-phosphate 5-kinase 9Add BLAST815

Proteomic databases

PaxDbiQ8L850
PRIDEiQ8L850

PTM databases

iPTMnetiQ8L850

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Inductioni

Transiently down-regulated by cold.1 Publication

Gene expression databases

ExpressionAtlasiQ8L850 baseline and differential
GenevisibleiQ8L850 AT

Interactioni

Subunit structurei

Interacts with CINV1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CINV1Q9LQF26EBI-2008013,EBI-2008033

Protein-protein interaction databases

BioGridi5485, 1 interactor
IntActiQ8L850, 1 interactor
STRINGi3702.AT3G09920.1

Structurei

3D structure databases

ProteinModelPortaliQ8L850
SMRiQ8L850
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati58 – 80MORN 1Add BLAST23
Repeati81 – 103MORN 2Add BLAST23
Repeati104 – 126MORN 3Add BLAST23
Repeati127 – 149MORN 4Add BLAST23
Repeati150 – 172MORN 5Add BLAST23
Repeati173 – 195MORN 6Add BLAST23
Repeati196 – 218MORN 7Add BLAST23
Repeati219 – 240MORN 8Add BLAST22
Domaini391 – 809PIPKPROSITE-ProRule annotationAdd BLAST419

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni769 – 790Activation loopBy similarityAdd BLAST22

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229 Eukaryota
COG4642 LUCA
COG5253 LUCA
HOGENOMiHOG000193875
InParanoidiQ8L850
KOiK00889
OMAiWIQGLGE
OrthoDBiEOG0936025Q
PhylomeDBiQ8L850

Family and domain databases

Gene3Di3.30.800.10, 1 hit
3.30.810.10, 2 hits
InterProiView protein in InterPro
IPR003409 MORN
IPR017163 PIno-4-P-5_kinase_pln
IPR023610 PInositol-4-P-5-kinase
IPR027483 PInositol-4-P-5-kinase_C
IPR002498 PInositol-4-P-5-kinase_core
IPR027484 PInositol-4-P-5-kinase_N
PANTHERiPTHR23086 PTHR23086, 1 hit
PfamiView protein in Pfam
PF02493 MORN, 8 hits
PF01504 PIP5K, 1 hit
PIRSFiPIRSF037274 PIP5K_plant_prd, 1 hit
SMARTiView protein in SMART
SM00698 MORN, 8 hits
SM00330 PIPKc, 1 hit
PROSITEiView protein in PROSITE
PS51455 PIPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q8L850-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGLDVRGAV SFAERTKSVD ALTKKEILSA LNSGEVSETS EDARFRVREL
60 70 80 90 100
VLPDGESYSG SLLGNVPEGP GKYIWSDGCV YDGEWRRGMR HGIGNMRWAS
110 120 130 140 150
GASYDGEFSG GYMHGSGTYV DANKLTYKGR WRLNLKHGLG YQVYPNGDVF
160 170 180 190 200
EGSWIQGLGE GPGKYTWANK NVYLGDMKGG KMSGKGTLTW VTGDSYEGSW
210 220 230 240 250
LNGMMHGVGV YTWSDGGCYV GTWTRGLKDG KGSFYSAGTR VPVVQEFYLN
260 270 280 290 300
ALRKRGVLPD MRRQNQVASS VNMENLRVGV NRNKLSKGSL INLEQSRNGR
310 320 330 340 350
VSLERRWSLE VSIEKVIGHG YSDLSTAVLD SGSSVQYKAN IPILEREYMQ
360 370 380 390 400
GVLISELVVN NGFSRTSRRA KRKHKRLVKE AKKPGEVVIK GHRSYDLMLS
410 420 430 440 450
LQLGIRYTVG KITPIQRRQV RTADFGPRAS FWMTFPRAGS TMTPPHHSED
460 470 480 490 500
FKWKDYCPMV FRNLREMFKI DAADYMMSIC GNDTLRELSS PGKSGSVFFL
510 520 530 540 550
SQDDRFMIKT LRKSEVKVLL RMLPDYHHHV KTYENTLITK FFGLHRIKPS
560 570 580 590 600
SGQKFRFVVM GNMFFTDLRI HRRFDLKGSS LGRSADKVEI DENTILKDLD
610 620 630 640 650
LNYSFFLETS WREGLLRQLE IDSKFLEAQN IMDYSLLLGV HHRAPQHLRS
660 670 680 690 700
QLVRSQSITT DALESVAEDD TIEDDMLSYH EGLVLVPRGS ENTVTGPHIR
710 720 730 740 750
GSRLRASAVG DEEVDLLLPG TARLQIQQGV NMPARAELIP GREDKEKQIL
760 770 780 790 800
HDCCDVVLYL GIIDILQEYN MTKKIEHAYK SLHFDSLSIS AVDPTFYSQR
810
FLEFIKKVFP QNNKS
Length:815
Mass (Da):92,092
Last modified:October 25, 2005 - v2
Checksum:i3194F009D2C50130
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti482N → K in AAM53300 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ810853 mRNA Translation: CAH18644.1
AC015985 Genomic DNA Translation: AAF23244.1
CP002686 Genomic DNA Translation: AEE74832.1
CP002686 Genomic DNA Translation: AEE74833.1
CP002686 Genomic DNA Translation: AEE74834.1
CP002686 Genomic DNA Translation: ANM65698.1
AY120742 mRNA Translation: AAM53300.1
AK229815 mRNA Translation: BAF01646.1
RefSeqiNP_001030666.1, NM_001035589.3
NP_001189852.1, NM_001202923.1
NP_001327647.1, NM_001337850.1
NP_187603.1, NM_111827.3
UniGeneiAt.40019

Genome annotation databases

EnsemblPlantsiAT3G09920.1; AT3G09920.1; AT3G09920
AT3G09920.2; AT3G09920.2; AT3G09920
AT3G09920.3; AT3G09920.3; AT3G09920
AT3G09920.4; AT3G09920.4; AT3G09920
GeneIDi820151
GrameneiAT3G09920.1; AT3G09920.1; AT3G09920
AT3G09920.2; AT3G09920.2; AT3G09920
AT3G09920.3; AT3G09920.3; AT3G09920
AT3G09920.4; AT3G09920.4; AT3G09920
KEGGiath:AT3G09920

Similar proteinsi

Entry informationi

Entry nameiPI5K9_ARATH
AccessioniPrimary (citable) accession number: Q8L850
Secondary accession number(s): Q0WMK5, Q9SF93
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: October 25, 2005
Last modified: April 25, 2018
This is version 112 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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