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Protein

Chaperonin CPN60-like 1, mitochondrial

Gene

At2g33210

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: TAIR
  • copper ion binding Source: TAIR
  • protein binding involved in protein folding Source: GO_Central
  • unfolded protein binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionChaperone
Biological processStress response
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Chaperonin CPN60-like 1, mitochondrial
Alternative name(s):
HSP60-like 1
Gene namesi
Ordered Locus Names:At2g33210
ORF Names:F25I18.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G33210.
TAIRilocus:2046590. AT2G33210.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 32MitochondrionSequence analysisAdd BLAST32
ChainiPRO_000004579233 – 585Chaperonin CPN60-like 1, mitochondrialAdd BLAST553

Proteomic databases

PaxDbiQ8L7B5.
PRIDEiQ8L7B5.

Expressioni

Gene expression databases

ExpressionAtlasiQ8L7B5. baseline and differential.
GenevisibleiQ8L7B5. AT.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi3230. 4 interactors.
IntActiQ8L7B5. 2 interactors.
STRINGi3702.AT2G33210.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L7B5.
SMRiQ8L7B5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi565 – 584Gly-richAdd BLAST20

Sequence similaritiesi

Belongs to the chaperonin (HSP60) family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0356. Eukaryota.
COG0459. LUCA.
HOGENOMiHOG000076290.
InParanoidiQ8L7B5.
KOiK04077.
OMAiCVIKVGA.
OrthoDBiEOG093606CJ.
PhylomeDBiQ8L7B5.

Family and domain databases

CDDicd03344. GroEL. 1 hit.
Gene3Di1.10.560.10. 2 hits.
3.50.7.10. 1 hit.
HAMAPiMF_00600. CH60. 1 hit.
InterProiView protein in InterPro
IPR018370. Chaperonin_Cpn60_CS.
IPR001844. Chaprnin_Cpn60.
IPR002423. Cpn60/TCP-1.
IPR027409. GroEL-like_apical_dom.
IPR027413. GROEL-like_equatorial.
IPR027410. TCP-1-like_intermed.
PANTHERiPTHR11353. PTHR11353. 1 hit.
PfamiView protein in Pfam
PF00118. Cpn60_TCP1. 1 hit.
PRINTSiPR00298. CHAPERONIN60.
SUPFAMiSSF48592. SSF48592. 2 hits.
SSF52029. SSF52029. 1 hit.
SSF54849. SSF54849. 1 hit.
TIGRFAMsiTIGR02348. GroEL. 1 hit.
PROSITEiView protein in PROSITE
PS00296. CHAPERONINS_CPN60. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8L7B5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYRLVSNVAS KARIARKCTS QIGSRLNSTR NYAAKDIRFG VEARALMLRG
60 70 80 90 100
VEDLADAVKV TMGPKGRNVI IEQSWGAPKV TKDGVTVAKS IEFKDRIKNV
110 120 130 140 150
GASLVKQVAN ATNDVAGDGT TCATVLTRAI FTEGCKSVAA GMNAMDLRRG
160 170 180 190 200
IKLAVDTVVT NLQSRARMIS TSEEIAQVGT ISANGDREIG ELIAKAMETV
210 220 230 240 250
GKEGVITIQD GKTLFNELEV VEGMKIDRGY ISPYFITNPK TQKCELEDPL
260 270 280 290 300
ILIHEKKISN INAMVKVLEL ALKKQRPLLI VAEDVESDAL ATLILNKLRA
310 320 330 340 350
NIKVCAVKAP GFGENRKANL HDLAALTGAQ VITEELGMNL DNIDLSMFGN
360 370 380 390 400
CKKVTVSKDD TVVLDGAGDK QAIGERCEQI RSMVEASTSD YDKEKLQERL
410 420 430 440 450
AKLSGGVAVL KIGGASETEV SEKKDRVTDA LNATKAAVEE GIVPGGGVAL
460 470 480 490 500
LYASKELEKL STANFDQKIG VQIIQNALKT PVYTIASNAG VEGAVVVGKL
510 520 530 540 550
LEQDNPDLGY DAAKGEYVDM IKAGIIDPLK VIRTALVDAA SVSSLLTTTE
560 570 580
AVVTEIPTKE VASPGMGGGG MGGMGGMGGM GGMGF
Length:585
Mass (Da):61,978
Last modified:October 1, 2002 - v1
Checksum:iA512B6975E674B4A
GO

Sequence cautioni

Q8L7B5: The sequence AAC04902 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002334 Genomic DNA. Translation: AAC04902.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC08799.1.
AY136360 mRNA. Translation: AAM97026.1.
BT000103 mRNA. Translation: AAN15422.1.
AK175415 mRNA. Translation: BAD43178.1.
PIRiF84742.
RefSeqiNP_850203.1. NM_179872.3. [Q8L7B5-1]
UniGeneiAt.27615.

Genome annotation databases

EnsemblPlantsiAT2G33210.1; AT2G33210.1; AT2G33210. [Q8L7B5-1]
GeneIDi817883.
GrameneiAT2G33210.1; AT2G33210.1; AT2G33210.
KEGGiath:AT2G33210.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCH60B_ARATH
AccessioniPrimary (citable) accession number: Q8L7B5
Secondary accession number(s): O49314
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families