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Protein

Vacuolar cation/proton exchanger 5

Gene

CAX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar cation/proton exchanger 5
Alternative name(s):
Ca(2+)/H(+) antiporter CAX5
Ca(2+)/H(+) exchanger 5
Protein CATION EXCHANGER 5
Gene namesi
Name:CAX5
Ordered Locus Names:At1g55730
ORF Names:F20N2.14, F20N2.16, F20N2.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G55730.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 69CytoplasmicSequence analysisAdd BLAST68
Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Topological domaini91 – 97ExtracellularSequence analysis7
Transmembranei98 – 118HelicalSequence analysisAdd BLAST21
Topological domaini119 – 129CytoplasmicSequence analysisAdd BLAST11
Transmembranei130 – 150HelicalSequence analysisAdd BLAST21
Topological domaini151 – 165ExtracellularSequence analysisAdd BLAST15
Transmembranei166 – 186HelicalSequence analysisAdd BLAST21
Topological domaini187 – 197CytoplasmicSequence analysisAdd BLAST11
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 231ExtracellularSequence analysisAdd BLAST13
Transmembranei232 – 252HelicalSequence analysisAdd BLAST21
Topological domaini253 – 286CytoplasmicSequence analysisAdd BLAST34
Transmembranei287 – 307HelicalSequence analysisAdd BLAST21
Topological domaini308 – 311ExtracellularSequence analysis4
Transmembranei312 – 332HelicalSequence analysisAdd BLAST21
Topological domaini333 – 354CytoplasmicSequence analysisAdd BLAST22
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 384ExtracellularSequence analysis9
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Topological domaini406 – 412CytoplasmicSequence analysis7
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Topological domaini434 – 441ExtracellularSequence analysis8

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002701542 – 441Vacuolar cation/proton exchanger 5Add BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1
Lipidationi3S-palmitoyl cysteineSequence analysis1
Lipidationi4S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiQ8L783.

PTM databases

iPTMnetiQ8L783.

Expressioni

Gene expression databases

ExpressionAtlasiQ8L783. baseline and differential.
GenevisibleiQ8L783. AT.

Interactioni

Protein-protein interaction databases

BioGridi27247. 1 interactor.
STRINGi3702.AT1G55730.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L783.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni139 – 174Cation selectionSequence analysisAdd BLAST36
Regioni333 – 368Cation selectionSequence analysisAdd BLAST36

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1397. Eukaryota.
COG0387. LUCA.
HOGENOMiHOG000083011.
KOiK07300.
OMAiEQVFDKG.
OrthoDBiEOG09360D5E.
PhylomeDBiQ8L783.

Family and domain databases

InterProiIPR004713. CaH_exchang.
IPR004798. CAX.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00846. caca2. 1 hit.
TIGR00378. cax. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8L783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCKVPALI QAQVEMGLVN DVEHKSLFRR DTDSPERKAA SLMEQGSLSA
60 70 80 90 100
SFRECSTKTP NNSVLQSFKI VILSNKLNLL LPFGPLAILL HYLTDNKGWI
110 120 130 140 150
FLLSLVGITP LAERLGYATE QLACYTGSTV GGLLNATFGN VTELIISIFA
160 170 180 190 200
LKSGMIRVVQ LTLLGSILSN MLLVLGCAFF CGGLVFSQKE QVFDKGNAVV
210 220 230 240 250
NSGLLLMAVM GLLFPAVLHY THSEVHAGSS ELALSRFSSC IMLVAYAAYL
260 270 280 290 300
FFQLKSQPSS YTPLTEETNQ NEETSDDDED PEISKWEAII WLSILTAWVS
310 320 330 340 350
LLSGYLVDAI EGASVSWKIP ISFISVILLP IVGNAAEHAG AIMFAMKDKL
360 370 380 390 400
DLSLGVAIGS SIQISMFAVP FCVVIGWMMG AQMDLNFQLF ETATLFITVI
410 420 430 440
VVAFFLQEGT SNYFKGLMLI LCYLIVAASF FVHEDPHQDD I
Length:441
Mass (Da):48,096
Last modified:October 1, 2002 - v1
Checksum:iC0319778C9C6476F
GO

Sequence cautioni

The sequence AAF79504 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At1g55730 and At1g55740.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79504.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33290.1.
CP002684 Genomic DNA. Translation: AEE33291.1.
AY136416 mRNA. Translation: AAM97082.1.
BT006591 mRNA. Translation: AAP31935.1.
PIRiC96599.
RefSeqiNP_001031196.1. NM_001036119.2.
NP_175969.2. NM_104449.3.
UniGeneiAt.23075.

Genome annotation databases

EnsemblPlantsiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
GeneIDi842022.
GrameneiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
KEGGiath:AT1G55730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79504.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33290.1.
CP002684 Genomic DNA. Translation: AEE33291.1.
AY136416 mRNA. Translation: AAM97082.1.
BT006591 mRNA. Translation: AAP31935.1.
PIRiC96599.
RefSeqiNP_001031196.1. NM_001036119.2.
NP_175969.2. NM_104449.3.
UniGeneiAt.23075.

3D structure databases

ProteinModelPortaliQ8L783.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27247. 1 interactor.
STRINGi3702.AT1G55730.1.

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.

PTM databases

iPTMnetiQ8L783.

Proteomic databases

PaxDbiQ8L783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
GeneIDi842022.
GrameneiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
KEGGiath:AT1G55730.

Organism-specific databases

TAIRiAT1G55730.

Phylogenomic databases

eggNOGiKOG1397. Eukaryota.
COG0387. LUCA.
HOGENOMiHOG000083011.
KOiK07300.
OMAiEQVFDKG.
OrthoDBiEOG09360D5E.
PhylomeDBiQ8L783.

Miscellaneous databases

PROiQ8L783.

Gene expression databases

ExpressionAtlasiQ8L783. baseline and differential.
GenevisibleiQ8L783. AT.

Family and domain databases

InterProiIPR004713. CaH_exchang.
IPR004798. CAX.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00846. caca2. 1 hit.
TIGR00378. cax. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAX5_ARATH
AccessioniPrimary (citable) accession number: Q8L783
Secondary accession number(s): Q9LFZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.