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Protein

Vacuolar cation/proton exchanger 5

Gene

CAX5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Vacuolar cation/proton exchanger (CAX). Translocates Ca2+ and other metal ions into vacuoles using the proton gradient formed by H+-ATPase and H+-pyrophosphatase (By similarity).By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Biological processi

Antiport, Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.

Names & Taxonomyi

Protein namesi
Recommended name:
Vacuolar cation/proton exchanger 5
Alternative name(s):
Ca(2+)/H(+) antiporter CAX5
Ca(2+)/H(+) exchanger 5
Protein CATION EXCHANGER 5
Gene namesi
Name:CAX5
Ordered Locus Names:At1g55730
ORF Names:F20N2.14, F20N2.16, F20N2.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G55730.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 6968CytoplasmicSequence analysisAdd
BLAST
Transmembranei70 – 9021HelicalSequence analysisAdd
BLAST
Topological domaini91 – 977ExtracellularSequence analysis
Transmembranei98 – 11821HelicalSequence analysisAdd
BLAST
Topological domaini119 – 12911CytoplasmicSequence analysisAdd
BLAST
Transmembranei130 – 15021HelicalSequence analysisAdd
BLAST
Topological domaini151 – 16515ExtracellularSequence analysisAdd
BLAST
Transmembranei166 – 18621HelicalSequence analysisAdd
BLAST
Topological domaini187 – 19711CytoplasmicSequence analysisAdd
BLAST
Transmembranei198 – 21821HelicalSequence analysisAdd
BLAST
Topological domaini219 – 23113ExtracellularSequence analysisAdd
BLAST
Transmembranei232 – 25221HelicalSequence analysisAdd
BLAST
Topological domaini253 – 28634CytoplasmicSequence analysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence analysisAdd
BLAST
Topological domaini308 – 3114ExtracellularSequence analysis
Transmembranei312 – 33221HelicalSequence analysisAdd
BLAST
Topological domaini333 – 35422CytoplasmicSequence analysisAdd
BLAST
Transmembranei355 – 37521HelicalSequence analysisAdd
BLAST
Topological domaini376 – 3849ExtracellularSequence analysis
Transmembranei385 – 40521HelicalSequence analysisAdd
BLAST
Topological domaini406 – 4127CytoplasmicSequence analysis
Transmembranei413 – 43321HelicalSequence analysisAdd
BLAST
Topological domaini434 – 4418ExtracellularSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 441440Vacuolar cation/proton exchanger 5PRO_0000270154Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis
Lipidationi3 – 31S-palmitoyl cysteineSequence analysis
Lipidationi4 – 41S-palmitoyl cysteineSequence analysis

Keywords - PTMi

Lipoprotein, Myristate, Palmitate

Proteomic databases

PaxDbiQ8L783.

PTM databases

iPTMnetiQ8L783.

Expressioni

Gene expression databases

ExpressionAtlasiQ8L783. baseline and differential.
GenevisibleiQ8L783. AT.

Interactioni

Protein-protein interaction databases

BioGridi27247. 1 interaction.
STRINGi3702.AT1G55730.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L783.
SMRiQ8L783. Positions 63-435.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni139 – 17436Cation selectionSequence analysisAdd
BLAST
Regioni333 – 36836Cation selectionSequence analysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1397. Eukaryota.
COG0387. LUCA.
HOGENOMiHOG000083011.
KOiK07300.
OMAiEQVFDKG.
OrthoDBiEOG09360D5E.
PhylomeDBiQ8L783.

Family and domain databases

InterProiIPR004713. CaH_exchang.
IPR004798. CAX.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00846. caca2. 1 hit.
TIGR00378. cax. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8L783-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGCCKVPALI QAQVEMGLVN DVEHKSLFRR DTDSPERKAA SLMEQGSLSA
60 70 80 90 100
SFRECSTKTP NNSVLQSFKI VILSNKLNLL LPFGPLAILL HYLTDNKGWI
110 120 130 140 150
FLLSLVGITP LAERLGYATE QLACYTGSTV GGLLNATFGN VTELIISIFA
160 170 180 190 200
LKSGMIRVVQ LTLLGSILSN MLLVLGCAFF CGGLVFSQKE QVFDKGNAVV
210 220 230 240 250
NSGLLLMAVM GLLFPAVLHY THSEVHAGSS ELALSRFSSC IMLVAYAAYL
260 270 280 290 300
FFQLKSQPSS YTPLTEETNQ NEETSDDDED PEISKWEAII WLSILTAWVS
310 320 330 340 350
LLSGYLVDAI EGASVSWKIP ISFISVILLP IVGNAAEHAG AIMFAMKDKL
360 370 380 390 400
DLSLGVAIGS SIQISMFAVP FCVVIGWMMG AQMDLNFQLF ETATLFITVI
410 420 430 440
VVAFFLQEGT SNYFKGLMLI LCYLIVAASF FVHEDPHQDD I
Length:441
Mass (Da):48,096
Last modified:October 1, 2002 - v1
Checksum:iC0319778C9C6476F
GO

Sequence cautioni

The sequence AAF79504 differs from that shown. Reason: Erroneous gene model prediction. The predicted gene has been split into 2 genes: At1g55730 and At1g55740.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79504.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33290.1.
CP002684 Genomic DNA. Translation: AEE33291.1.
AY136416 mRNA. Translation: AAM97082.1.
BT006591 mRNA. Translation: AAP31935.1.
PIRiC96599.
RefSeqiNP_001031196.1. NM_001036119.1.
NP_175969.2. NM_104449.3.
UniGeneiAt.23075.

Genome annotation databases

EnsemblPlantsiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
GeneIDi842022.
GrameneiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
KEGGiath:AT1G55730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002328 Genomic DNA. Translation: AAF79504.1. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33290.1.
CP002684 Genomic DNA. Translation: AEE33291.1.
AY136416 mRNA. Translation: AAM97082.1.
BT006591 mRNA. Translation: AAP31935.1.
PIRiC96599.
RefSeqiNP_001031196.1. NM_001036119.1.
NP_175969.2. NM_104449.3.
UniGeneiAt.23075.

3D structure databases

ProteinModelPortaliQ8L783.
SMRiQ8L783. Positions 63-435.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi27247. 1 interaction.
STRINGi3702.AT1G55730.1.

Protein family/group databases

CAZyiGH36. Glycoside Hydrolase Family 36.

PTM databases

iPTMnetiQ8L783.

Proteomic databases

PaxDbiQ8L783.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
GeneIDi842022.
GrameneiAT1G55730.1; AT1G55730.1; AT1G55730.
AT1G55730.2; AT1G55730.2; AT1G55730.
KEGGiath:AT1G55730.

Organism-specific databases

TAIRiAT1G55730.

Phylogenomic databases

eggNOGiKOG1397. Eukaryota.
COG0387. LUCA.
HOGENOMiHOG000083011.
KOiK07300.
OMAiEQVFDKG.
OrthoDBiEOG09360D5E.
PhylomeDBiQ8L783.

Miscellaneous databases

PROiQ8L783.

Gene expression databases

ExpressionAtlasiQ8L783. baseline and differential.
GenevisibleiQ8L783. AT.

Family and domain databases

InterProiIPR004713. CaH_exchang.
IPR004798. CAX.
IPR004837. NaCa_Exmemb.
[Graphical view]
PfamiPF01699. Na_Ca_ex. 2 hits.
[Graphical view]
TIGRFAMsiTIGR00846. caca2. 1 hit.
TIGR00378. cax. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAX5_ARATH
AccessioniPrimary (citable) accession number: Q8L783
Secondary accession number(s): Q9LFZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.