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Protein

F-box/kelch-repeat protein SKIP11

Gene

SKIP11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/kelch-repeat protein SKIP11
Alternative name(s):
SKP1-interacting partner 11
Gene namesi
Name:SKIP11
Ordered Locus Names:At2g02870
ORF Names:T17M13.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G02870.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • nucleus Source: TAIR
  • SCF ubiquitin ligase complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002831911 – 467F-box/kelch-repeat protein SKIP11Add BLAST467

Proteomic databases

PaxDbiQ8L736.

Expressioni

Gene expression databases

GenevisibleiQ8L736. AT.

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1 and SPK1B/ASK2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220. 2 interactors.
IntActiQ8L736. 2 interactors.
STRINGi3702.AT2G02870.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini116 – 163F-boxAdd BLAST48
Repeati159 – 210Kelch 1Add BLAST52
Repeati215 – 259Kelch 2Add BLAST45
Repeati261 – 307Kelch 3Add BLAST47
Repeati308 – 356Kelch 4Add BLAST49
Repeati365 – 411Kelch 5Add BLAST47

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Sequence similaritiesi

Contains 1 F-box domain.Curated
Contains 5 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
HOGENOMiHOG000239488.
InParanoidiQ8L736.
OMAiRGTWRVI.
OrthoDBiEOG093609U4.
PhylomeDBiQ8L736.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8L736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEDRSPDSC LSTRVFSSSR LSESNWSNSY MYPEDDDKLL GNGKRALEVV
60 70 80 90 100
GEVRQTKSLK LMGFSIIYDS DSSDYSLSGG EEQADAAIGD GSSSRQEQEQ
110 120 130 140 150
QSDFNDNGGD SSDSHSLINE IGRDNSIDCL IRCSRSDYGS IASLNRNFRS
160 170 180 190 200
LVKSGEIYRL RRQNGFVEHW VYFSCQLLEW VAFDPVERRW MQLPTMPSSV
210 220 230 240 250
TFMCADKESL AVGTDLLVLG KDDFSSHVIY RYSLLTNSWS SGMKMNSPRC
260 270 280 290 300
LFGSASLGEI AIFAGGCDSQ GKILDFAEMY NSELQTWITL PRMNKPRKMC
310 320 330 340 350
SGVFMDGKFY VIGGIGGADS KGLTCGEEYD LETKKWTQIP DLSPPRSRAD
360 370 380 390 400
QADMSPAAEA PPLVAVVNNQ LYAADHADME VRKYDKENKK WLTVGRLPER
410 420 430 440 450
AGSVNGWGLA FRACGERLIV IGGPKCSGGG FIELNSWIPS DGGPPQWTLL
460
DRKHSPTFVY NCAVMGC
Length:467
Mass (Da):51,698
Last modified:April 3, 2007 - v2
Checksum:i17229589475E13C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti394V → I in AAM98120 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004138 Genomic DNA. Translation: AAC32908.1.
CP002685 Genomic DNA. Translation: AEC05636.1.
CP002685 Genomic DNA. Translation: AEC05637.1.
CP002685 Genomic DNA. Translation: AEC05638.1.
AY060567 mRNA. Translation: AAL31196.1.
AY139977 mRNA. Translation: AAM98120.1.
BT002216 mRNA. Translation: AAN72228.1.
AK317194 mRNA. Translation: BAH19879.1.
PIRiH84441.
RefSeqiNP_001030959.1. NM_001035882.1.
NP_001030960.1. NM_001035883.2.
NP_178390.1. NM_126342.4.
UniGeneiAt.27431.

Genome annotation databases

EnsemblPlantsiAT2G02870.1; AT2G02870.1; AT2G02870.
AT2G02870.2; AT2G02870.2; AT2G02870.
AT2G02870.3; AT2G02870.3; AT2G02870.
GeneIDi814818.
GrameneiAT2G02870.1; AT2G02870.1; AT2G02870.
AT2G02870.2; AT2G02870.2; AT2G02870.
AT2G02870.3; AT2G02870.3; AT2G02870.
KEGGiath:AT2G02870.

Cross-referencesi

Web resourcesi

PlantsUBQ

A functional genomics database for the ubiquitin/26S proteasome proteolytic pathway in plants

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004138 Genomic DNA. Translation: AAC32908.1.
CP002685 Genomic DNA. Translation: AEC05636.1.
CP002685 Genomic DNA. Translation: AEC05637.1.
CP002685 Genomic DNA. Translation: AEC05638.1.
AY060567 mRNA. Translation: AAL31196.1.
AY139977 mRNA. Translation: AAM98120.1.
BT002216 mRNA. Translation: AAN72228.1.
AK317194 mRNA. Translation: BAH19879.1.
PIRiH84441.
RefSeqiNP_001030959.1. NM_001035882.1.
NP_001030960.1. NM_001035883.2.
NP_178390.1. NM_126342.4.
UniGeneiAt.27431.

3D structure databases

ProteinModelPortaliQ8L736.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220. 2 interactors.
IntActiQ8L736. 2 interactors.
STRINGi3702.AT2G02870.1.

Proteomic databases

PaxDbiQ8L736.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G02870.1; AT2G02870.1; AT2G02870.
AT2G02870.2; AT2G02870.2; AT2G02870.
AT2G02870.3; AT2G02870.3; AT2G02870.
GeneIDi814818.
GrameneiAT2G02870.1; AT2G02870.1; AT2G02870.
AT2G02870.2; AT2G02870.2; AT2G02870.
AT2G02870.3; AT2G02870.3; AT2G02870.
KEGGiath:AT2G02870.

Organism-specific databases

TAIRiAT2G02870.

Phylogenomic databases

eggNOGiKOG1072. Eukaryota.
ENOG4110X8D. LUCA.
HOGENOMiHOG000239488.
InParanoidiQ8L736.
OMAiRGTWRVI.
OrthoDBiEOG093609U4.
PhylomeDBiQ8L736.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

PROiQ8L736.

Gene expression databases

GenevisibleiQ8L736. AT.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
[Graphical view]
PfamiPF01344. Kelch_1. 2 hits.
[Graphical view]
SMARTiSM00612. Kelch. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSKI11_ARATH
AccessioniPrimary (citable) accession number: Q8L736
Secondary accession number(s): B9DGL2, O80606
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 30, 2016
This is version 88 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.