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Q8L727

- GSTT2_ARATH

UniProt

Q8L727 - GSTT2_ARATH

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Protein

Glutathione S-transferase T2

Gene

GSTT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC

GO - Biological processi

  1. response to toxic substance Source: UniProtKB-KW
  2. toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT5G41240-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T2 (EC:2.5.1.18)
Short name:
AtGSTT2
Alternative name(s):
GST class-theta member 2
Glutathione S-transferase 10B
Gene namesi
Name:GSTT2
Synonyms:GST10B
Ordered Locus Names:At5g41240/At5g41230
ORF Names:K1O13.3/K1O13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 5

Organism-specific databases

TAIRiAT5G41240.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: TAIR
  2. peroxisome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 591591Glutathione S-transferase T2PRO_0000413575Add
BLAST

Proteomic databases

PaxDbiQ8L727.
PRIDEiQ8L727.

Expressioni

Gene expression databases

GenevestigatoriQ8L727.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G41240.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ8L727.
SMRiQ8L727. Positions 1-250.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 8282GST N-terminalAdd
BLAST
Domaini89 – 226138GST C-terminalAdd
BLAST
Domaini265 – 33874Myb-likePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni11 – 122Glutathione bindingBy similarity
Regioni40 – 412Glutathione bindingBy similarity
Regioni53 – 542Glutathione bindingBy similarity
Regioni66 – 672Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated
Contains 1 Myb-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0625.
HOGENOMiHOG000148624.
InParanoidiQ8L727.
OMAiVILISAW.
PhylomeDBiQ8L727.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017877. Myb-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8L727-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLKVYADRM SQPSRAVLIF CKVNEIQFDE ILISLGKRQQ LSPEFKEINP
60 70 80 90 100
MGKVPAIVDG RLKLFESHAI LIYLSSAYAS VVDHWYPNDL SKRAKIHSVL
110 120 130 140 150
DWHHTNLRPG ASGYVLNSVL APALGLPLNP KAAAEAENIL TNSLSTLETF
160 170 180 190 200
WLKGSAKFLL GGKQPSIADL SLVCELMQLQ VLDDKDRLRL LSPHKKVEQW
210 220 230 240 250
IESTRKATMP HSDEVHEVLF RAKDRFQKQR EMATASKPGP QSKIIQFSSI
260 270 280 290 300
GGTSDGPNLV QDTTDRKARR RKWSPPDDVI LISAWLNTSK DRKVVVYDEQ
310 320 330 340 350
QAHTFWKRIG AHVSNSASLA NLPKREWNHC RQRWRKINDY VCKFVGCYDQ
360 370 380 390 400
ALNQRASGQS EDDVFQVAYQ LYYNNYMSNF KLEHAWRELR HNKKWCSTYT
410 420 430 440 450
SENSKGGGSS KRTKLNGGGV YSSSCNPESV PIALDGEEQV MDRPLGVKSS
460 470 480 490 500
KQKEKKVATK TMLEEREADS RSRLENLWVL DEEEQVMDLP LGVKSSKQKE
510 520 530 540 550
RKVATKTMIE EREAANFRSR LGNLWLLKEK EEREADSRSR LENLWALKEK
560 570 580 590
DIEEQKKLTR MEVLKSLLGR RTGETSEKEE TLKNKLIDEM L
Length:591
Mass (Da):67,689
Last modified:October 1, 2002 - v1
Checksum:iD1F401C7FDA853D9
GO

Sequence cautioni

The sequence CAA10662.1 differs from that shown. Reason: Sequencing errors.
The sequence BAB11099.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.
The sequence BAB11100.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 11M → MM in CAA10662. 1 PublicationCurated
Sequence conflicti9 – 91R → K in CAA10662. 1 PublicationCurated
Sequence conflicti125 – 1251G → S in CAA10662. 1 PublicationCurated
Sequence conflicti244 – 2441I → M in CAA10662. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019225 Genomic DNA. Translation: BAB11099.1. Sequence problems.
AB019225 Genomic DNA. Translation: BAB11100.1. Sequence problems.
CP002688 Genomic DNA. Translation: AED94656.1.
AY139996 mRNA. Translation: AAM98138.1.
BT008361 mRNA. Translation: AAP37720.1.
AJ132398 mRNA. Translation: CAA10662.1. Sequence problems.
PIRiT52580.
RefSeqiNP_198940.3. NM_123489.3.
UniGeneiAt.22919.

Genome annotation databases

EnsemblPlantsiAT5G41240.1; AT5G41240.1; AT5G41240.
GeneIDi834125.
KEGGiath:AT5G41240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB019225 Genomic DNA. Translation: BAB11099.1 . Sequence problems.
AB019225 Genomic DNA. Translation: BAB11100.1 . Sequence problems.
CP002688 Genomic DNA. Translation: AED94656.1 .
AY139996 mRNA. Translation: AAM98138.1 .
BT008361 mRNA. Translation: AAP37720.1 .
AJ132398 mRNA. Translation: CAA10662.1 . Sequence problems.
PIRi T52580.
RefSeqi NP_198940.3. NM_123489.3.
UniGenei At.22919.

3D structure databases

ProteinModelPortali Q8L727.
SMRi Q8L727. Positions 1-250.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT5G41240.1-P.

Proteomic databases

PaxDbi Q8L727.
PRIDEi Q8L727.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT5G41240.1 ; AT5G41240.1 ; AT5G41240 .
GeneIDi 834125.
KEGGi ath:AT5G41240.

Organism-specific databases

TAIRi AT5G41240.

Phylogenomic databases

eggNOGi COG0625.
HOGENOMi HOG000148624.
InParanoidi Q8L727.
OMAi VILISAW.
PhylomeDBi Q8L727.

Enzyme and pathway databases

BioCyci ARA:AT5G41240-MONOMER.

Gene expression databases

Genevestigatori Q8L727.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR017877. Myb-like_dom.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF02798. GST_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
PS50090. MYB_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
    Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
    DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Identification and cloning of AtGST 10, members of a novel type of plant glutathione transferases."
    Dixon D.P., Cole D.J., Edwards R.
    Plant Gene Register PGR99-053
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-245.
    Strain: cv. Columbia.
  5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
    Wagner U., Edwards R., Dixon D.P., Mauch F.
    Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.
  6. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
    Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
    J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.

Entry informationi

Entry nameiGSTT2_ARATH
AccessioniPrimary (citable) accession number: Q8L727
Secondary accession number(s): Q9FHD9, Q9FHE0, Q9ZRR6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3