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Protein

Glutathione S-transferase T2

Gene

GSTT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT5G41240-MONOMER
ReactomeiR-ATH-156590 Glutathione conjugation

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase T2 (EC:2.5.1.18)
Short name:
AtGSTT2
Alternative name(s):
GST class-theta member 2
Glutathione S-transferase 10B
Gene namesi
Name:GSTT2
Synonyms:GST10B
Ordered Locus Names:At5g41240/At5g41230
ORF Names:K1O13.3/K1O13.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 5

Organism-specific databases

AraportiAT5G41240
TAIRilocus:2155105 AT5G41240

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135751 – 591Glutathione S-transferase T2Add BLAST591

Proteomic databases

PaxDbiQ8L727

Expressioni

Gene expression databases

ExpressionAtlasiQ8L727 baseline and differential
GenevisibleiQ8L727 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT5G41240.1

Structurei

3D structure databases

ProteinModelPortaliQ8L727
SMRiQ8L727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 82GST N-terminalAdd BLAST82
Domaini89 – 226GST C-terminalAdd BLAST138
Domaini265 – 338Myb-likePROSITE-ProRule annotationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni11 – 12Glutathione bindingBy similarity2
Regioni40 – 41Glutathione bindingBy similarity2
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated

Phylogenomic databases

eggNOGiKOG0867 Eukaryota
COG0625 LUCA
HOGENOMiHOG000148624
InParanoidiQ8L727
KOiK00799
OrthoDBiEOG09360L2Z
PhylomeDBiQ8L727

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR017877 Myb-like_dom
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF02798 GST_N, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit
PS50090 MYB_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8L727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLKVYADRM SQPSRAVLIF CKVNEIQFDE ILISLGKRQQ LSPEFKEINP
60 70 80 90 100
MGKVPAIVDG RLKLFESHAI LIYLSSAYAS VVDHWYPNDL SKRAKIHSVL
110 120 130 140 150
DWHHTNLRPG ASGYVLNSVL APALGLPLNP KAAAEAENIL TNSLSTLETF
160 170 180 190 200
WLKGSAKFLL GGKQPSIADL SLVCELMQLQ VLDDKDRLRL LSPHKKVEQW
210 220 230 240 250
IESTRKATMP HSDEVHEVLF RAKDRFQKQR EMATASKPGP QSKIIQFSSI
260 270 280 290 300
GGTSDGPNLV QDTTDRKARR RKWSPPDDVI LISAWLNTSK DRKVVVYDEQ
310 320 330 340 350
QAHTFWKRIG AHVSNSASLA NLPKREWNHC RQRWRKINDY VCKFVGCYDQ
360 370 380 390 400
ALNQRASGQS EDDVFQVAYQ LYYNNYMSNF KLEHAWRELR HNKKWCSTYT
410 420 430 440 450
SENSKGGGSS KRTKLNGGGV YSSSCNPESV PIALDGEEQV MDRPLGVKSS
460 470 480 490 500
KQKEKKVATK TMLEEREADS RSRLENLWVL DEEEQVMDLP LGVKSSKQKE
510 520 530 540 550
RKVATKTMIE EREAANFRSR LGNLWLLKEK EEREADSRSR LENLWALKEK
560 570 580 590
DIEEQKKLTR MEVLKSLLGR RTGETSEKEE TLKNKLIDEM L
Length:591
Mass (Da):67,689
Last modified:October 1, 2002 - v1
Checksum:iD1F401C7FDA853D9
GO

Sequence cautioni

The sequence BAB11099 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.Curated
The sequence BAB11100 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.Curated
The sequence CAA10662 differs from that shown. Sequencing errors.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → MM in CAA10662 (Ref. 4) Curated1
Sequence conflicti9R → K in CAA10662 (Ref. 4) Curated1
Sequence conflicti125G → S in CAA10662 (Ref. 4) Curated1
Sequence conflicti244I → M in CAA10662 (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB019225 Genomic DNA Translation: BAB11099.1 Sequence problems.
AB019225 Genomic DNA Translation: BAB11100.1 Sequence problems.
CP002688 Genomic DNA Translation: AED94656.1
AY139996 mRNA Translation: AAM98138.1
BT008361 mRNA Translation: AAP37720.1
AJ132398 mRNA Translation: CAA10662.1 Sequence problems.
PIRiT52580
RefSeqiNP_198940.3, NM_123489.4
UniGeneiAt.22919

Genome annotation databases

EnsemblPlantsiAT5G41240.1; AT5G41240.1; AT5G41240
GeneIDi834125
GrameneiAT5G41240.1; AT5G41240.1; AT5G41240
KEGGiath:AT5G41240

Similar proteinsi

Entry informationi

Entry nameiGSTT2_ARATH
AccessioniPrimary (citable) accession number: Q8L727
Secondary accession number(s): Q9FHD9, Q9FHE0, Q9ZRR6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome