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Q8L727

- GSTT2_ARATH

UniProt

Q8L727 - GSTT2_ARATH

Protein

Glutathione S-transferase T2

Gene

GSTT2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. response to toxic substance Source: UniProtKB-KW
    2. toxin catabolic process Source: TAIR

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Detoxification

    Enzyme and pathway databases

    BioCyciARA:AT5G41240-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione S-transferase T2 (EC:2.5.1.18)
    Short name:
    AtGSTT2
    Alternative name(s):
    GST class-theta member 2
    Glutathione S-transferase 10B
    Gene namesi
    Name:GSTT2
    Synonyms:GST10B
    Ordered Locus Names:At5g41240/At5g41230
    ORF Names:K1O13.3/K1O13.2
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 5

    Organism-specific databases

    TAIRiAT5G41240.

    Subcellular locationi

    Peroxisome 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: TAIR
    2. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 591591Glutathione S-transferase T2PRO_0000413575Add
    BLAST

    Proteomic databases

    PaxDbiQ8L727.
    PRIDEiQ8L727.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8L727.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT5G41240.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8L727.
    SMRiQ8L727. Positions 1-250.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 8282GST N-terminalAdd
    BLAST
    Domaini89 – 226138GST C-terminalAdd
    BLAST
    Domaini265 – 33874Myb-likePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni11 – 122Glutathione bindingBy similarity
    Regioni40 – 412Glutathione bindingBy similarity
    Regioni53 – 542Glutathione bindingBy similarity
    Regioni66 – 672Glutathione bindingBy similarity

    Sequence similaritiesi

    Belongs to the GST superfamily. Theta family.Curated
    Contains 1 GST C-terminal domain.Curated
    Contains 1 GST N-terminal domain.Curated
    Contains 1 Myb-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0625.
    HOGENOMiHOG000148624.
    InParanoidiQ8L727.
    OMAiVILISAW.
    PhylomeDBiQ8L727.

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR017877. Myb-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF02798. GST_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    PS50090. MYB_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8L727-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLKVYADRM SQPSRAVLIF CKVNEIQFDE ILISLGKRQQ LSPEFKEINP    50
    MGKVPAIVDG RLKLFESHAI LIYLSSAYAS VVDHWYPNDL SKRAKIHSVL 100
    DWHHTNLRPG ASGYVLNSVL APALGLPLNP KAAAEAENIL TNSLSTLETF 150
    WLKGSAKFLL GGKQPSIADL SLVCELMQLQ VLDDKDRLRL LSPHKKVEQW 200
    IESTRKATMP HSDEVHEVLF RAKDRFQKQR EMATASKPGP QSKIIQFSSI 250
    GGTSDGPNLV QDTTDRKARR RKWSPPDDVI LISAWLNTSK DRKVVVYDEQ 300
    QAHTFWKRIG AHVSNSASLA NLPKREWNHC RQRWRKINDY VCKFVGCYDQ 350
    ALNQRASGQS EDDVFQVAYQ LYYNNYMSNF KLEHAWRELR HNKKWCSTYT 400
    SENSKGGGSS KRTKLNGGGV YSSSCNPESV PIALDGEEQV MDRPLGVKSS 450
    KQKEKKVATK TMLEEREADS RSRLENLWVL DEEEQVMDLP LGVKSSKQKE 500
    RKVATKTMIE EREAANFRSR LGNLWLLKEK EEREADSRSR LENLWALKEK 550
    DIEEQKKLTR MEVLKSLLGR RTGETSEKEE TLKNKLIDEM L 591
    Length:591
    Mass (Da):67,689
    Last modified:October 1, 2002 - v1
    Checksum:iD1F401C7FDA853D9
    GO

    Sequence cautioni

    The sequence CAA10662.1 differs from that shown. Reason: Sequencing errors.
    The sequence BAB11099.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.
    The sequence BAB11100.1 differs from that shown. Reason: Erroneous gene model prediction. Was originally thought to correspond to two different genes At5g41230 and At5g41240.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 11M → MM in CAA10662. 1 PublicationCurated
    Sequence conflicti9 – 91R → K in CAA10662. 1 PublicationCurated
    Sequence conflicti125 – 1251G → S in CAA10662. 1 PublicationCurated
    Sequence conflicti244 – 2441I → M in CAA10662. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019225 Genomic DNA. Translation: BAB11099.1. Sequence problems.
    AB019225 Genomic DNA. Translation: BAB11100.1. Sequence problems.
    CP002688 Genomic DNA. Translation: AED94656.1.
    AY139996 mRNA. Translation: AAM98138.1.
    BT008361 mRNA. Translation: AAP37720.1.
    AJ132398 mRNA. Translation: CAA10662.1. Sequence problems.
    PIRiT52580.
    RefSeqiNP_198940.3. NM_123489.3.
    UniGeneiAt.22919.

    Genome annotation databases

    EnsemblPlantsiAT5G41240.1; AT5G41240.1; AT5G41240.
    GeneIDi834125.
    KEGGiath:AT5G41240.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB019225 Genomic DNA. Translation: BAB11099.1 . Sequence problems.
    AB019225 Genomic DNA. Translation: BAB11100.1 . Sequence problems.
    CP002688 Genomic DNA. Translation: AED94656.1 .
    AY139996 mRNA. Translation: AAM98138.1 .
    BT008361 mRNA. Translation: AAP37720.1 .
    AJ132398 mRNA. Translation: CAA10662.1 . Sequence problems.
    PIRi T52580.
    RefSeqi NP_198940.3. NM_123489.3.
    UniGenei At.22919.

    3D structure databases

    ProteinModelPortali Q8L727.
    SMRi Q8L727. Positions 1-250.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT5G41240.1-P.

    Proteomic databases

    PaxDbi Q8L727.
    PRIDEi Q8L727.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT5G41240.1 ; AT5G41240.1 ; AT5G41240 .
    GeneIDi 834125.
    KEGGi ath:AT5G41240.

    Organism-specific databases

    TAIRi AT5G41240.

    Phylogenomic databases

    eggNOGi COG0625.
    HOGENOMi HOG000148624.
    InParanoidi Q8L727.
    OMAi VILISAW.
    PhylomeDBi Q8L727.

    Enzyme and pathway databases

    BioCyci ARA:AT5G41240-MONOMER.

    Gene expression databases

    Genevestigatori Q8L727.

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR017877. Myb-like_dom.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF02798. GST_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50405. GST_CTER. 1 hit.
    PS50404. GST_NTER. 1 hit.
    PS50090. MYB_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence features of the regions of 3,076,755 bp covered by sixty P1 and TAC clones."
      Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H., Tabata S.
      DNA Res. 7:31-63(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Identification and cloning of AtGST 10, members of a novel type of plant glutathione transferases."
      Dixon D.P., Cole D.J., Edwards R.
      Plant Gene Register PGR99-053
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-245.
      Strain: cv. Columbia.
    5. "Probing the diversity of the Arabidopsis glutathione S-transferase gene family."
      Wagner U., Edwards R., Dixon D.P., Mauch F.
      Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    6. "Enzyme activities and subcellular localization of members of the Arabidopsis glutathione transferase superfamily."
      Dixon D.P., Hawkins T., Hussey P.J., Edwards R.
      J. Exp. Bot. 60:1207-1218(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiGSTT2_ARATH
    AccessioniPrimary (citable) accession number: Q8L727
    Secondary accession number(s): Q9FHD9, Q9FHE0, Q9ZRR6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2011
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3