ID   PIF6_ARATH              Reviewed;         363 AA.
AC   Q8L5W7; A8MSC2; Q9M1R5;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 31.
DE   RecName: Full=Transcription factor PIF6;
DE   AltName: Full=Protein PHYTOCHROME-INTERACTING FACTOR 6;
DE   AltName: Full=Protein PHYTOCHROME INTERACTING FACTOR 3-LIKE 2;
DE   AltName: Full=Transcription factor EN 111;
DE   AltName: Full=bHLH transcription factor bHLH132;
DE   AltName: Full=Basic helix-loop-helix protein 132;
DE            Short=bHLH 132;
DE            Short=AtbHLH132;
GN   Name=PIF6; Synonyms=BHLH132, EN111, PIL2; OrderedLocusNames=At3g62090;
GN   ORFNames=T17J13.50;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; core eudicotyledons;
OC   rosids; eurosids II; Brassicales; Brassicaceae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   MEDLINE=21686507; PubMed=11828023; DOI=10.1093/pcp/pcf005;
RA   Makino S., Matsushika A., Kojima M., Yamashino T., Mizuno T.;
RT   "The APRR1/TOC1 quintet implicated in circadian rhythms of Arabidopsis
RT   thaliana: I. Characterization with APRR1-overexpressing plants.";
RL   Plant Cell Physiol. 43:58-69(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   MEDLINE=21016720; PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M.,
RA   Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B.,
RA   Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P.,
RA   De Simone V., Choisne N., Artiguenave F., Robert C., Brottier P.,
RA   Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V.,
RA   Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S.,
RA   Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G.,
RA   Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B.,
RA   Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G.,
RA   Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J.,
RA   Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D.,
RA   Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D.,
RA   Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W.,
RA   Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J.,
RA   Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P.,
RA   Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S.,
RA   Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V.,
RA   Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C.,
RA   Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E.,
RA   Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y.,
RA   Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A.,
RA   Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   STRAIN=cv. Columbia;
RA   De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J.,
RA   Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   MEDLINE=22598051; PubMed=12679534; DOI=10.1093/molbev/msg088;
RA   Heim M.A., Jakoby M., Werber M., Martin C., Weisshaar B., Bailey P.C.;
RT   "The basic helix-loop-helix transcription factor family in plants: a
RT   genome-wide study of protein structure and functional diversity.";
RL   Mol. Biol. Evol. 20:735-747(2003).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=12897250; DOI=10.1105/tpc.013839;
RA   Toledo-Ortiz G., Huq E., Quail P.H.;
RT   "The Arabidopsis basic/helix-loop-helix transcription factor family.";
RL   Plant Cell 15:1749-1770(2003).
RN   [6]
RP   INTERACTION WITH APRR1/TOC1.
RX   PubMed=12826627; DOI=10.1093/pcp/pcg078;
RA   Yamashino T., Matsushika A., Fujimori T., Sato S., Kato T., Tabata S.,
RA   Mizuno T.;
RT   "A Link between circadian-controlled bHLH factors and the APRR1/TOC1
RT   quintet in Arabidopsis thaliana.";
RL   Plant Cell Physiol. 44:619-629(2003).
CC   -!- SUBUNIT: Homodimer (Probable). Interacts with APRR1/TOC1.
CC   -!- INTERACTION:
CC       P14713:PHYB; NbExp=1; IntAct=EBI-631639, EBI-300727;
CC   -!- SUBCELLULAR LOCATION: Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8L5W7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8L5W7-2; Sequence=VSP_036113;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Contains 1 basic helix-loop-helix (bHLH) domain.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAB71869.1; Type=Erroneous gene model prediction;
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DR   EMBL; AB090874; BAC10690.1; -; Transcribed_RNA.
DR   EMBL; AL138651; CAB71869.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BT033108; ACF16169.1; -; mRNA.
DR   IPI; IPI00525935; -.
DR   IPI; IPI00846835; -.
DR   PIR; T48001; T48001.
DR   RefSeq; NP_001078329.1; -.
DR   UniGene; At.1005; -.
DR   UniGene; At.50304; -.
DR   IntAct; Q8L5W7; 1.
DR   GeneID; 825382; -.
DR   GenomeReviews; BA000014_GR; AT3G62090.
DR   KEGG; ath:AT3G62090; -.
DR   NMPDR; fig|3702.1.peg.17591; -.
DR   TAIR; At3g62090; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0030528; F:transcription regulator activity; IEA:InterPro.
DR   GO; GO:0010017; P:red or far red light signaling pathway; IEP:TAIR.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR001092; HLH_basic.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   PROSITE; PS50888; HLH; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Complete proteome; DNA-binding; Nucleus;
KW   Transcription; Transcription regulation.
FT   CHAIN         1    363       Transcription factor PIF6.
FT                                /FTId=PRO_0000358852.
FT   DOMAIN      202    242       Helix-loop-helix motif.
FT   DNA_BIND    185    201       Basic motif (By similarity).
FT   COMPBIAS    243    276       Met-rich.
FT   VAR_SEQ       1     17       Missing (in isoform 2).
FT                                /FTId=VSP_036113.
SQ   SEQUENCE   363 AA;  40547 MW;  15AD124E07949873 CRC64;
     MMFLPTDYCC RLSDQEYMEL VFENGQILAK GQRSNVSLHN QRTKSIMDLY EAEYNEDFMK
     SIIHGGGGAI TNLGDTQVVP QSHVAAAHET NMLESNKHVD DSETLKASSS KRMMVDYHNR
     KKIKFIPPDE QSVVADRSFK LGFDTSSVGF TEDSEGSMYL SSSLDDESDD ARPQVPARTR
     KALVKRKRNA EAYNSPERNQ RNDINKKMRT LQNLLPNSHK DDNESMLDEA INYMTNLQLQ
     VQMMTMGNRF VTPSMMMPLG PNYSQMGLAM GVGMQMGEQQ FLPAHVLGAG LPGINDSADM
     LRFLNHPGLM PMQNSAPFIP TENCSPQSVP PSCAAFPNQI PNPNSLSNLD GATLHKKSRK
     TNR
//