ID   Q8L5J8_COLES            Unreviewed;       205 AA.
AC   Q8L5J8;
DT   01-OCT-2002, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2002, sequence version 1.
DT   27-MAR-2024, entry version 78.
DE   RecName: Full=Cysteine proteinase inhibitor {ECO:0000256|RuleBase:RU362130};
GN   Name=CPI {ECO:0000313|EMBL:AAM88397.1};
OS   Colocasia esculenta (Wild taro) (Arum esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Araceae; Aroideae; Colocasieae;
OC   Colocasia.
OX   NCBI_TaxID=4460 {ECO:0000313|EMBL:AAM88397.1};
RN   [1] {ECO:0000313|EMBL:AAM88397.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Mature corm {ECO:0000313|EMBL:AAM88397.1};
RX   PubMed=15647900; DOI=10.1007/s00425-004-1462-8;
RA   Yang A.H., Yeh K.W.;
RT   "Molecular cloning, recombinant gene expression, and antifungal activity of
RT   cystatin from taro (Colocasia esculenta cv. Kaosiung no. 1).";
RL   Planta 221:493-501(2005).
RN   [2] {ECO:0007829|PDB:3IMA}
RP   X-RAY CRYSTALLOGRAPHY (2.03 ANGSTROMS) OF 2-92.
RX   PubMed=21416241; DOI=10.1007/s00425-011-1398-8;
RA   Chu M.H., Liu K.L., Wu H.Y., Yeh K.W., Cheng Y.S.;
RT   "Crystal structure of tarocystatin-papain complex: implications for the
RT   inhibition property of group-2 phytocystatins.";
RL   Planta 234:243-254(2011).
CC   -!- SIMILARITY: Belongs to the cystatin family. Phytocystatin subfamily.
CC       {ECO:0000256|ARBA:ARBA00007233, ECO:0000256|RuleBase:RU362130}.
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DR   EMBL; AF525880; AAM88397.1; -; mRNA.
DR   PDB; 3IMA; X-ray; 2.03 A; B/D=2-92.
DR   PDBsum; 3IMA; -.
DR   AlphaFoldDB; Q8L5J8; -.
DR   SMR; Q8L5J8; -.
DR   MEROPS; I25.014; -.
DR   EvolutionaryTrace; Q8L5J8; -.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   CDD; cd00042; CY; 1.
DR   Gene3D; 3.10.450.10; -; 2.
DR   InterPro; IPR027214; Cystatin.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   PANTHER; PTHR11413; CYSTATIN FAMILY MEMBER; 1.
DR   PANTHER; PTHR11413:SF103; CYSTEINE PROTEINASE INHIBITOR 6; 1.
DR   Pfam; PF16845; SQAPI; 1.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; Cystatin/monellin; 2.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:3IMA};
KW   Protease inhibitor {ECO:0000256|ARBA:ARBA00022690,
KW   ECO:0000256|RuleBase:RU362130};
KW   Thiol protease inhibitor {ECO:0000256|ARBA:ARBA00022704,
KW   ECO:0000256|RuleBase:RU362130}.
FT   DOMAIN          2..92
FT                   /note="Cystatin"
FT                   /evidence="ECO:0000259|SMART:SM00043"
SQ   SEQUENCE   205 AA;  23035 MW;  05330FF1902118C6 CRC64;
     MALMGGIVDV EGAQNSAEVE ELARFAVDEH NKKENALLQF SRLVKAKQQV VSGIMHHLTV
     EVIEGGKKKV YEAKVWVQAW LNSKKLHEFS PIGDSSSVTP ADLGVKRDAH EAEWLEIPTH
     DPVVQDAANH AVKSIQQRSN TLFPYELLEI LHAKAKVLED LAKIHLLLKL KRGSREEKFK
     VEVHKNIEGT FHLNQMEQDH SDSGN
//