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Q8L518

- CK2_ARATH

UniProt

Q8L518 - CK2_ARATH

Protein

Probable choline kinase 2

Gene

At1g74320

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis By similarity.By similarity

    Catalytic activityi

    ATP + choline = ADP + phosphocholine.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei73 – 731ATPBy similarity
    Binding sitei210 – 2101ATPBy similarity
    Binding sitei227 – 2271ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. choline kinase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G74320-MONOMER.
    UniPathwayiUPA00753; UER00737.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable choline kinase 2 (EC:2.7.1.32)
    Gene namesi
    Ordered Locus Names:At1g74320
    ORF Names:F1O17.1
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G74320.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Probable choline kinase 2PRO_0000423347Add
    BLAST

    Proteomic databases

    PRIDEiQ8L518.

    Expressioni

    Inductioni

    By wounding, and salt and osmotic stresses.1 Publication

    Gene expression databases

    GenevestigatoriQ8L518.

    Interactioni

    Protein-protein interaction databases

    STRINGi3702.AT1G74320.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8L518.
    SMRiQ8L518. Positions 46-343.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the choline/ethanolamine kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0510.
    HOGENOMiHOG000041274.
    InParanoidiQ8L518.
    KOiK14156.
    OMAiEIDFDYM.
    PhylomeDBiQ8L518.

    Family and domain databases

    InterProiIPR026712. Cho/Etha_kinase.
    IPR011009. Kinase-like_dom.
    [Graphical view]
    PANTHERiPTHR22603:SF32. PTHR22603:SF32. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8L518-1 [UniParc]FASTAAdd to Basket

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    MTMGGTEKNV ENKQYRLPRE VKEALQAIAS EWEDVIDSKA LQVIPLKGAM    50
    TNEVFQIKWP TREKGPSRKV LVRIYGEGVE IFFDREDEIR TFEFMSKHGH 100
    GPLLLGRFGN GRIEEFLHAR TLSACDLRDP EISGRIATRM KEFHGLEMPG 150
    AKKALLWDRL RNWLTACKRL ASPEEAKSFR LDVMEMEINM LEKSLFDNDE 200
    NIGFCHNDLQ YGNIMMDEET KAITIIDYEY SCYNPVAYDI ANHFCEMAAD 250
    YHTETPHIMD YSKYPGVEER QRFLKTYMSY SDEKPSDTMV KKLLEDVEKY 300
    TLASHLIWGL WGIISEHVNE IDFDYMEYAR QRFEQYWLTK PRLLAASEHK 350
    Length:350
    Mass (Da):41,017
    Last modified:October 1, 2002 - v1
    Checksum:i2C38393ADA5D2465
    GO

    Sequence cautioni

    The sequence AAG52400.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020579 Genomic DNA. Translation: AAG52400.1. Different initiation.
    CP002684 Genomic DNA. Translation: AEE35577.1.
    AY094430 mRNA. Translation: AAM19803.1.
    AY140093 mRNA. Translation: AAM98234.1.
    BT008737 mRNA. Translation: AAP42750.1.
    PIRiG96771.
    RefSeqiNP_177572.2. NM_106092.3.
    UniGeneiAt.43684.

    Genome annotation databases

    EnsemblPlantsiAT1G74320.1; AT1G74320.1; AT1G74320.
    GeneIDi843772.
    KEGGiath:AT1G74320.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC020579 Genomic DNA. Translation: AAG52400.1 . Different initiation.
    CP002684 Genomic DNA. Translation: AEE35577.1 .
    AY094430 mRNA. Translation: AAM19803.1 .
    AY140093 mRNA. Translation: AAM98234.1 .
    BT008737 mRNA. Translation: AAP42750.1 .
    PIRi G96771.
    RefSeqi NP_177572.2. NM_106092.3.
    UniGenei At.43684.

    3D structure databases

    ProteinModelPortali Q8L518.
    SMRi Q8L518. Positions 46-343.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 3702.AT1G74320.1-P.

    Proteomic databases

    PRIDEi Q8L518.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G74320.1 ; AT1G74320.1 ; AT1G74320 .
    GeneIDi 843772.
    KEGGi ath:AT1G74320.

    Organism-specific databases

    TAIRi AT1G74320.

    Phylogenomic databases

    eggNOGi COG0510.
    HOGENOMi HOG000041274.
    InParanoidi Q8L518.
    KOi K14156.
    OMAi EIDFDYM.
    PhylomeDBi Q8L518.

    Enzyme and pathway databases

    UniPathwayi UPA00753 ; UER00737 .
    BioCyci ARA:AT1G74320-MONOMER.

    Gene expression databases

    Genevestigatori Q8L518.

    Family and domain databases

    InterProi IPR026712. Cho/Etha_kinase.
    IPR011009. Kinase-like_dom.
    [Graphical view ]
    PANTHERi PTHR22603:SF32. PTHR22603:SF32. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana."
      Tasseva G., Richard L., Zachowski A.
      FEBS Lett. 566:115-120(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.

    Entry informationi

    Entry nameiCK2_ARATH
    AccessioniPrimary (citable) accession number: Q8L518
    Secondary accession number(s): Q9C916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 18, 2013
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3