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Protein

Probable choline kinase 2

Gene

At1g74320

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis (By similarity).By similarity

Catalytic activityi

ATP + choline = ADP + phosphocholine.

Pathwayi: phosphatidylcholine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes phosphocholine from choline.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable choline kinase 2 (At1g74320), Probable choline kinase 3 (At4g09760), Probable choline kinase 1 (CK1)
This subpathway is part of the pathway phosphatidylcholine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphocholine from choline, the pathway phosphatidylcholine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei73ATPBy similarity1
Binding sitei210ATPBy similarity1
Binding sitei227ATPBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT1G74320-MONOMER
ReactomeiR-ATH-1483191 Synthesis of PC
R-ATH-1483213 Synthesis of PE
UniPathwayiUPA00753; UER00737

Names & Taxonomyi

Protein namesi
Recommended name:
Probable choline kinase 2 (EC:2.7.1.32)
Gene namesi
Ordered Locus Names:At1g74320
ORF Names:F1O17.1
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G74320
TAIRilocus:2019612 AT1G74320

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004233471 – 350Probable choline kinase 2Add BLAST350

Proteomic databases

PaxDbiQ8L518

Expressioni

Inductioni

By wounding, and salt and osmotic stresses.1 Publication

Gene expression databases

ExpressionAtlasiQ8L518 baseline and differential
GenevisibleiQ8L518 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT1G74320.1

Structurei

3D structure databases

ProteinModelPortaliQ8L518
SMRiQ8L518
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the choline/ethanolamine kinase family.Curated

Phylogenomic databases

eggNOGiKOG2686 Eukaryota
COG0510 LUCA
HOGENOMiHOG000041274
InParanoidiQ8L518
KOiK14156
OMAiRAYLWCK
OrthoDBiEOG09360D8L
PhylomeDBiQ8L518

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
SUPFAMiSSF56112 SSF56112, 1 hit

Sequencei

Sequence statusi: Complete.

Q8L518-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMGGTEKNV ENKQYRLPRE VKEALQAIAS EWEDVIDSKA LQVIPLKGAM
60 70 80 90 100
TNEVFQIKWP TREKGPSRKV LVRIYGEGVE IFFDREDEIR TFEFMSKHGH
110 120 130 140 150
GPLLLGRFGN GRIEEFLHAR TLSACDLRDP EISGRIATRM KEFHGLEMPG
160 170 180 190 200
AKKALLWDRL RNWLTACKRL ASPEEAKSFR LDVMEMEINM LEKSLFDNDE
210 220 230 240 250
NIGFCHNDLQ YGNIMMDEET KAITIIDYEY SCYNPVAYDI ANHFCEMAAD
260 270 280 290 300
YHTETPHIMD YSKYPGVEER QRFLKTYMSY SDEKPSDTMV KKLLEDVEKY
310 320 330 340 350
TLASHLIWGL WGIISEHVNE IDFDYMEYAR QRFEQYWLTK PRLLAASEHK
Length:350
Mass (Da):41,017
Last modified:October 1, 2002 - v1
Checksum:i2C38393ADA5D2465
GO

Sequence cautioni

The sequence AAG52400 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC020579 Genomic DNA Translation: AAG52400.1 Different initiation.
CP002684 Genomic DNA Translation: AEE35577.1
AY094430 mRNA Translation: AAM19803.1
AY140093 mRNA Translation: AAM98234.1
BT008737 mRNA Translation: AAP42750.1
PIRiG96771
RefSeqiNP_177572.2, NM_106092.4
UniGeneiAt.43684

Genome annotation databases

EnsemblPlantsiAT1G74320.1; AT1G74320.1; AT1G74320
GeneIDi843772
GrameneiAT1G74320.1; AT1G74320.1; AT1G74320
KEGGiath:AT1G74320

Similar proteinsi

Entry informationi

Entry nameiCK2_ARATH
AccessioniPrimary (citable) accession number: Q8L518
Secondary accession number(s): Q9C916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health