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Q8L518 (CK2_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable choline kinase 2

EC=2.7.1.32
Gene names
Ordered Locus Names:At1g74320
ORF Names:F1O17.1
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in phospholipid biosynthesis. Catalyzes the first step in phosphatidylcholine biosynthesis By similarity.

Catalytic activity

ATP + choline = ADP + phosphocholine.

Pathway

Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1.

Induction

By wounding, and salt and osmotic stresses. Ref.4

Sequence similarities

Belongs to the choline/ethanolamine kinase family.

Sequence caution

The sequence AAG52400.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Probable choline kinase 2
PRO_0000423347

Sites

Binding site731ATP By similarity
Binding site2101ATP By similarity
Binding site2271ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8L518 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2C38393ADA5D2465

FASTA35041,017
        10         20         30         40         50         60 
MTMGGTEKNV ENKQYRLPRE VKEALQAIAS EWEDVIDSKA LQVIPLKGAM TNEVFQIKWP 

        70         80         90        100        110        120 
TREKGPSRKV LVRIYGEGVE IFFDREDEIR TFEFMSKHGH GPLLLGRFGN GRIEEFLHAR 

       130        140        150        160        170        180 
TLSACDLRDP EISGRIATRM KEFHGLEMPG AKKALLWDRL RNWLTACKRL ASPEEAKSFR 

       190        200        210        220        230        240 
LDVMEMEINM LEKSLFDNDE NIGFCHNDLQ YGNIMMDEET KAITIIDYEY SCYNPVAYDI 

       250        260        270        280        290        300 
ANHFCEMAAD YHTETPHIMD YSKYPGVEER QRFLKTYMSY SDEKPSDTMV KKLLEDVEKY 

       310        320        330        340        350 
TLASHLIWGL WGIISEHVNE IDFDYMEYAR QRFEQYWLTK PRLLAASEHK 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Regulation of phosphatidylcholine biosynthesis under salt stress involves choline kinases in Arabidopsis thaliana."
Tasseva G., Richard L., Zachowski A.
FEBS Lett. 566:115-120(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC020579 Genomic DNA. Translation: AAG52400.1. Different initiation.
CP002684 Genomic DNA. Translation: AEE35577.1.
AY094430 mRNA. Translation: AAM19803.1.
AY140093 mRNA. Translation: AAM98234.1.
BT008737 mRNA. Translation: AAP42750.1.
PIRG96771.
RefSeqNP_177572.2. NM_106092.3.
UniGeneAt.43684.

3D structure databases

ProteinModelPortalQ8L518.
SMRQ8L518. Positions 46-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING3702.AT1G74320.1-P.

Proteomic databases

PRIDEQ8L518.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G74320.1; AT1G74320.1; AT1G74320.
GeneID843772.
KEGGath:AT1G74320.

Organism-specific databases

TAIRAT1G74320.

Phylogenomic databases

eggNOGCOG0510.
HOGENOMHOG000041274.
InParanoidQ8L518.
KOK14156.
OMAEIDFDYM.
PhylomeDBQ8L518.

Enzyme and pathway databases

BioCycARA:AT1G74320-MONOMER.
UniPathwayUPA00753; UER00737.

Gene expression databases

GenevestigatorQ8L518.

Family and domain databases

InterProIPR026712. Cho/Etha_kinase.
IPR011009. Kinase-like_dom.
[Graphical view]
PANTHERPTHR22603:SF32. PTHR22603:SF32. 1 hit.
SUPFAMSSF56112. SSF56112. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCK2_ARATH
AccessionPrimary (citable) accession number: Q8L518
Secondary accession number(s): Q9C916
Entry history
Integrated into UniProtKB/Swiss-Prot: September 18, 2013
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names