ID APRR9_ARATH Reviewed; 468 AA. AC Q8L500; O81035; Q9LKL1; DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot. DT 27-SEP-2004, sequence version 2. DT 27-MAR-2024, entry version 137. DE RecName: Full=Two-component response regulator-like APRR9; DE AltName: Full=Pseudo-response regulator 9; GN Name=APRR9; OrderedLocusNames=At2g46790; ORFNames=F19D11.7; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION. RX PubMed=11100772; DOI=10.1093/pcp/pcd043; RA Matsushika A., Makino S., Kojima M., Mizuno T.; RT "Circadian waves of expression of the APRR1/TOC1 family of pseudo-response RT regulators in Arabidopsis thaliana: insight into the plant circadian RT clock."; RL Plant Cell Physiol. 41:1002-1012(2000). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=cv. Columbia; RX PubMed=10926537; DOI=10.1126/science.289.5480.768; RA Strayer C., Oyama T., Schultz T.F., Raman R., Somers D.E., Mas P., RA Panda S., Kreps J.A., Kay S.A.; RT "Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response RT regulator homolog."; RL Science 289:768-771(2000). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."; RL Nature 402:761-768(1999). RN [4] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC STRAIN=cv. Columbia; RX PubMed=14593172; DOI=10.1126/science.1088305; RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L., RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., RA Ecker J.R.; RT "Empirical analysis of transcriptional activity in the Arabidopsis RT genome."; RL Science 302:842-846(2003). RN [6] RP GENE FAMILY. RX PubMed=10945350; DOI=10.1093/pcp/41.6.791; RA Makino S., Kiba T., Imamura A., Hanaki N., Nakamura A., Suzuki T., RA Taniguchi M., Ueguchi C., Sugiyama T., Mizuno T.; RT "Genes encoding pseudo-response regulators: insight into His-to-Asp RT phosphorelay and circadian rhythm in Arabidopsis thaliana."; RL Plant Cell Physiol. 41:791-803(2000). RN [7] RP PHOSPHORYLATION. RX PubMed=18562312; DOI=10.1074/jbc.m803471200; RA Fujiwara S., Wang L., Han L., Suh S.-S., Salome P.A., McClung C.R., RA Somers D.E.; RT "Post-translational regulation of the Arabidopsis circadian clock through RT selective proteolysis and phosphorylation of pseudo-response regulator RT proteins."; RL J. Biol. Chem. 283:23073-23083(2008). RN [8] RP REGULATION. RX PubMed=20962777; DOI=10.1038/nature09470; RA Sanchez S.E., Petrillo E., Beckwith E.J., Zhang X., Rugnone M.L., RA Hernando C.E., Cuevas J.C., Godoy Herz M.A., Depetris-Chauvin A., RA Simpson C.G., Brown J.W., Cerdan P.D., Borevitz J.O., Mas P., Ceriani M.F., RA Kornblihtt A.R., Yanovsky M.J.; RT "A methyl transferase links the circadian clock to the regulation of RT alternative splicing."; RL Nature 468:112-116(2010). RN [9] RP FUNCTION. RX PubMed=20233950; DOI=10.1105/tpc.109.072892; RA Nakamichi N., Kiba T., Henriques R., Mizuno T., Chua N.H., Sakakibara H.; RT "PSEUDO-RESPONSE REGULATORS 9, 7, and 5 are transcriptional repressors in RT the Arabidopsis circadian clock."; RL Plant Cell 22:594-605(2010). RN [10] RP FUNCTION. RX PubMed=21098730; DOI=10.1105/tpc.110.079087; RA Salome P.A., Weigel D., McClung C.R.; RT "The role of the Arabidopsis morning loop components CCA1, LHY, PRR7, and RT PRR9 in temperature compensation."; RL Plant Cell 22:3650-3661(2010). RN [11] RP FUNCTION, AND INDUCTION. RX PubMed=21357491; DOI=10.1105/tpc.110.081661; RA Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.; RT "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive RT feedback regulatory loop in the Arabidopsis circadian clock."; RL Plant Cell 23:486-498(2011). RN [12] RP REGULATION. RX PubMed=22307044; DOI=10.4161/psb.18766; RA Chow B.Y., Helfer A., Nusinow D.A., Kay S.A.; RT "ELF3 recruitment to the PRR9 promoter requires other Evening Complex RT members in the Arabidopsis circadian clock."; RL Plant Signal. Behav. 7:170-173(2012). RN [13] RP REGULATION. RX PubMed=22327739; DOI=10.1105/tpc.111.093807; RA Herrero E., Kolmos E., Bujdoso N., Yuan Y., Wang M., Berns M.C., RA Uhlworm H., Coupland G., Saini R., Jaskolski M., Webb A., Goncalves J., RA Davis S.J.; RT "EARLY FLOWERING4 recruitment of EARLY FLOWERING3 in the nucleus sustains RT the Arabidopsis circadian clock."; RL Plant Cell 24:428-443(2012). RN [14] RP REGULATION. RX PubMed=22942380; DOI=10.1105/tpc.112.100081; RA Wang X., Wu F., Xie Q., Wang H., Wang Y., Yue Y., Gahura O., Ma S., Liu L., RA Cao Y., Jiao Y., Puta F., McClung C.R., Xu X., Ma L.; RT "SKIP is a component of the spliceosome linking alternative splicing and RT the circadian clock in Arabidopsis."; RL Plant Cell 24:3278-3295(2012). RN [15] RP FUNCTION. RX PubMed=23027938; DOI=10.1073/pnas.1205156109; RA Nakamichi N., Kiba T., Kamioka M., Suzuki T., Yamashino T., Higashiyama T., RA Sakakibara H., Mizuno T.; RT "Transcriptional repressor PRR5 directly regulates clock-output pathways."; RL Proc. Natl. Acad. Sci. U.S.A. 109:17123-17128(2012). RN [16] RP INDUCTION BY HEAT-SHOCK. RX PubMed=23933882; DOI=10.1105/tpc.113.114306; RA Karayekov E., Sellaro R., Legris M., Yanovsky M.J., Casal J.J.; RT "Heat shock-induced fluctuations in clock and light signaling enhance RT phytochrome B-mediated Arabidopsis deetiolation."; RL Plant Cell 25:2892-2906(2013). CC -!- FUNCTION: Transcriptional repressor of CCA1 and LHY, and positive CC regulator of LWD1 and LWD2 expression. Controls photoperiodic flowering CC response and temperature compensation. Involved in the positive and CC negative feedback loops of the circadian clock. Expression of several CC members of the ARR-like family is controlled by circadian rhythm. CC Regulated at the transcriptional level by a corepressor complex CC consisting of ELF4, ELF3, and LUX. APRR9, APRR7, and APRR5 coordinately CC act on the upstream region of the target genes to repress their CC expression from noon until midnight. The particular coordinated CC sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to CC circadian waves that may be at the basis of the endogenous circadian CC clock. {ECO:0000269|PubMed:11100772, ECO:0000269|PubMed:20233950, CC ECO:0000269|PubMed:21098730, ECO:0000269|PubMed:21357491, CC ECO:0000269|PubMed:23027938}. CC -!- INTERACTION: CC Q8L500; Q9SJU5: BBX18; NbExp=3; IntAct=EBI-7920168, EBI-15192077; CC Q8L500; C0SVM5: BBX19; NbExp=3; IntAct=EBI-7920168, EBI-4430993; CC Q8L500; Q8LCG7: NFYC2; NbExp=3; IntAct=EBI-7920168, EBI-2125983; CC Q8L500; Q9FMV5: NFYC4; NbExp=3; IntAct=EBI-7920168, EBI-2466018; CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=1; CC Comment=A number of isoforms are produced. According to EST CC sequences.; CC Name=1; CC IsoId=Q8L500-1; Sequence=Displayed; CC -!- INDUCTION: Up-regulated by heat-shock. {ECO:0000269|PubMed:21357491, CC ECO:0000269|PubMed:23933882}. CC -!- PTM: Phosphorylated. Phosphorylation varies throughout the diurnal CC cycle. {ECO:0000269|PubMed:18562312}. CC -!- MISCELLANEOUS: Regulated at the level of mRNA maturation and CC alternative splicing by SKIP (PubMed:22942380) and PRMT5 CC (PubMed:20962777). The expression of APRR9, APRR7, and APRR5 requires CC the presence of LWD1 and/or LWD2, indicating the existence of a CC positive feedback loop within the circadian clock (PubMed:21357491). CC {ECO:0000305|PubMed:20962777, ECO:0000305|PubMed:21357491, CC ECO:0000305|PubMed:22942380}. CC -!- SIMILARITY: Belongs to the ARR-like family. {ECO:0000305}. CC -!- CAUTION: Lacks the phospho-accepting Asp (here Glu-89), present in the CC receiver domain, which is one of the conserved features of two- CC component response regulators (ARRs) family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=AAM20527.1; Type=Frameshift; Evidence={ECO:0000305}; CC Sequence=AAM91256.1; Type=Frameshift; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AB046953; BAB13741.1; -; mRNA. DR EMBL; AF272040; AAF86253.1; -; mRNA. DR EMBL; AC005310; AAC33497.2; -; Genomic_DNA. DR EMBL; CP002685; AEC10754.1; -; Genomic_DNA. DR EMBL; AY099676; AAM20527.1; ALT_FRAME; mRNA. DR EMBL; AY128856; AAM91256.1; ALT_FRAME; mRNA. DR PIR; T02680; T02680. DR RefSeq; NP_001325091.1; NM_001337214.1. DR RefSeq; NP_001325092.1; NM_001337213.1. DR RefSeq; NP_566085.1; NM_130245.5. [Q8L500-1] DR AlphaFoldDB; Q8L500; -. DR SMR; Q8L500; -. DR BioGRID; 4627; 18. DR IntAct; Q8L500; 12. DR MINT; Q8L500; -. DR STRING; 3702.Q8L500; -. DR PaxDb; 3702-AT2G46790-1; -. DR EnsemblPlants; AT2G46790.1; AT2G46790.1; AT2G46790. [Q8L500-1] DR GeneID; 819292; -. DR Gramene; AT2G46790.1; AT2G46790.1; AT2G46790. [Q8L500-1] DR KEGG; ath:AT2G46790; -. DR Araport; AT2G46790; -. DR TAIR; AT2G46790; PRR9. DR eggNOG; KOG1601; Eukaryota. DR HOGENOM; CLU_041215_0_0_1; -. DR InParanoid; Q8L500; -. DR OMA; CTTPYLE; -. DR OrthoDB; 406014at2759; -. DR PhylomeDB; Q8L500; -. DR PRO; PR:Q8L500; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q8L500; baseline and differential. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0003677; F:DNA binding; IPI:TAIR. DR GO; GO:0007623; P:circadian rhythm; IMP:TAIR. DR GO; GO:0009736; P:cytokinin-activated signaling pathway; IEA:InterPro. DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:TAIR. DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW. DR GO; GO:0010017; P:red or far-red light signaling pathway; IMP:TAIR. DR GO; GO:0006355; P:regulation of DNA-templated transcription; TAS:TAIR. DR CDD; cd17582; psREC_PRR; 1. DR Gene3D; 3.40.50.2300; -; 1. DR InterPro; IPR045279; ARR-like. DR InterPro; IPR010402; CCT_domain. DR InterPro; IPR011006; CheY-like_superfamily. DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver. DR PANTHER; PTHR43874; TWO-COMPONENT RESPONSE REGULATOR; 1. DR PANTHER; PTHR43874:SF146; TWO-COMPONENT RESPONSE REGULATOR-LIKE APRR9; 1. DR Pfam; PF06203; CCT; 1. DR Pfam; PF00072; Response_reg; 1. DR SMART; SM00448; REC; 1. DR SUPFAM; SSF52172; CheY-like; 1. DR PROSITE; PS51017; CCT; 1. DR PROSITE; PS50110; RESPONSE_REGULATORY; 1. DR Genevisible; Q8L500; AT. PE 1: Evidence at protein level; KW Alternative splicing; Biological rhythms; Nucleus; Phosphoprotein; KW Reference proteome; Transcription; Transcription regulation; KW Two-component regulatory system. FT CHAIN 1..468 FT /note="Two-component response regulator-like APRR9" FT /id="PRO_0000081441" FT DOMAIN 38..156 FT /note="Response regulatory" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169" FT DOMAIN 417..459 FT /note="CCT" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00357" FT REGION 168..203 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 302..416 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 442..468 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 313..327 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 328..367 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 381..398 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 399..416 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 468 AA; 52565 MW; 19D6C9571CA77A40 CRC64; MGEIVVLSSD DGMETIKNRV KSSEVVQWEK YLPKTVLRVL LVESDYSTRQ IITALLRKCC YKVVAVSDGL AAWEVLKEKS HNIDLILTEL DLPSISGFAL LALVMEHEAC KNIPVIMMSS QDSIKMVLKC MLRGAADYLI KPMRKNELKN LWQHVWRRLT LRDDPTAHAQ SLPASQHNLE DTDETCEDSR YHSDQGSGAQ AINYNGHNKL MENGKSVDER DEFKETFDVT MDLIGGIDKR PDSIYKDKSR DECVGPELGL SLKRSCSVSF ENQDESKHQK LSLSDASAFS RFEESKSAEK AVVALEESTS GEPKTPTESH EKLRKVTSDQ GSATTSSNQE NIGSSSVSFR NQVLQSTVTN QKQDSPIPVE SNREKAASKE VEAGSQSTNE GIAGQSSSTE KPKEEESAKQ RWSRSQREAA LMKFRLKRKD RCFDKKVRYQ SRKKLAEQRP RVKGQFVRTV NSDASTKS //