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Protein

Two-component response regulator-like APRR9

Gene

APRR9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor of CCA1 and LHY, and positive regulator of LWD1 and LWD2 expression. Controls photoperiodic flowering response and temperature compensation. Involved in the positive and negative feedback loops of the circadian clock. Expression of several members of the ARR-like family is controlled by circadian rhythm. Regulated at the transcriptional level by a corepressor complex consisting of ELF4, ELF3, and LUX. APRR9, APRR7, and APRR5 coordinately act on the upstream region of the target genes to repress their expression from noon until midnight. The particular coordinated sequential expression of APRR9, APRR7, APRR5, APRR3 and APPR1 result to circadian waves that may be at the basis of the endogenous circadian clock.5 Publications

Miscellaneous

Regulated at the level of mRNA maturation and alternative splicing by SKIP (PubMed:22942380) and PRMT5 (PubMed:20962777). The expression of APRR9, APRR7, and APRR5 requires the presence of LWD1 and/or LWD2, indicating the existence of a positive feedback loop within the circadian clock (PubMed:21357491).3 Publications

Caution

Lacks the phospho-accepting Asp (here Glu-89), present in the receiver domain, which is one of the conserved features of two-component response regulators (ARRs) family.Curated

GO - Molecular functioni

  • DNA binding Source: TAIR

GO - Biological processi

  • circadian rhythm Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • phosphorelay signal transduction system Source: UniProtKB-KW
  • red or far-red light signaling pathway Source: TAIR
  • regulation of transcription, DNA-templated Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processBiological rhythms, Transcription, Transcription regulation, Two-component regulatory system

Names & Taxonomyi

Protein namesi
Recommended name:
Two-component response regulator-like APRR9
Alternative name(s):
Pseudo-response regulator 9
Gene namesi
Name:APRR9
Ordered Locus Names:At2g46790
ORF Names:F19D11.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G46790
TAIRilocus:2044376 AT2G46790

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814411 – 468Two-component response regulator-like APRR9Add BLAST468

Post-translational modificationi

Phosphorylated. Phosphorylation varies throughout the diurnal cycle.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8L500

Expressioni

Inductioni

Up-regulated by heat-shock.2 Publications

Gene expression databases

ExpressionAtlasiQ8L500 baseline and differential
GenevisibleiQ8L500 AT

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi46277 interactors.
IntActiQ8L500 10 interactors.
MINTiQ8L500
STRINGi3702.AT2G46790.1

Structurei

3D structure databases

ProteinModelPortaliQ8L500
SMRiQ8L500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 156Response regulatoryPROSITE-ProRule annotationAdd BLAST119
Domaini417 – 459CCTPROSITE-ProRule annotationAdd BLAST43

Sequence similaritiesi

Belongs to the ARR-like family.Curated

Phylogenomic databases

eggNOGiENOG410JXJV Eukaryota
COG5641 LUCA
HOGENOMiHOG000034018
InParanoidiQ8L500
KOiK12128
OMAiNNKLMED
OrthoDBiEOG093604X6
PhylomeDBiQ8L500

Family and domain databases

CDDicd00156 REC, 1 hit
InterProiView protein in InterPro
IPR010402 CCT_domain
IPR011006 CheY-like_superfamily
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF06203 CCT, 1 hit
PF00072 Response_reg, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
PROSITEiView protein in PROSITE
PS51017 CCT, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q8L500-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEIVVLSSD DGMETIKNRV KSSEVVQWEK YLPKTVLRVL LVESDYSTRQ
60 70 80 90 100
IITALLRKCC YKVVAVSDGL AAWEVLKEKS HNIDLILTEL DLPSISGFAL
110 120 130 140 150
LALVMEHEAC KNIPVIMMSS QDSIKMVLKC MLRGAADYLI KPMRKNELKN
160 170 180 190 200
LWQHVWRRLT LRDDPTAHAQ SLPASQHNLE DTDETCEDSR YHSDQGSGAQ
210 220 230 240 250
AINYNGHNKL MENGKSVDER DEFKETFDVT MDLIGGIDKR PDSIYKDKSR
260 270 280 290 300
DECVGPELGL SLKRSCSVSF ENQDESKHQK LSLSDASAFS RFEESKSAEK
310 320 330 340 350
AVVALEESTS GEPKTPTESH EKLRKVTSDQ GSATTSSNQE NIGSSSVSFR
360 370 380 390 400
NQVLQSTVTN QKQDSPIPVE SNREKAASKE VEAGSQSTNE GIAGQSSSTE
410 420 430 440 450
KPKEEESAKQ RWSRSQREAA LMKFRLKRKD RCFDKKVRYQ SRKKLAEQRP
460
RVKGQFVRTV NSDASTKS
Length:468
Mass (Da):52,565
Last modified:September 27, 2004 - v2
Checksum:i19D6C9571CA77A40
GO

Sequence cautioni

The sequence AAM20527 differs from that shown. Reason: Frameshift at position 117.Curated
The sequence AAM91256 differs from that shown. Reason: Frameshift at position 117.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB046953 mRNA Translation: BAB13741.1
AF272040 mRNA Translation: AAF86253.1
AC005310 Genomic DNA Translation: AAC33497.2
CP002685 Genomic DNA Translation: AEC10754.1
AY099676 mRNA Translation: AAM20527.1 Frameshift.
AY128856 mRNA Translation: AAM91256.1 Frameshift.
PIRiT02680
RefSeqiNP_001325091.1, NM_001337214.1
NP_001325092.1, NM_001337213.1
NP_566085.1, NM_130245.5 [Q8L500-1]
UniGeneiAt.1675
At.65052

Genome annotation databases

EnsemblPlantsiAT2G46790.1; AT2G46790.1; AT2G46790 [Q8L500-1]
GeneIDi819292
GrameneiAT2G46790.1; AT2G46790.1; AT2G46790 [Q8L500-1]
KEGGiath:AT2G46790

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAPRR9_ARATH
AccessioniPrimary (citable) accession number: Q8L500
Secondary accession number(s): O81035, Q9LKL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: September 27, 2004
Last modified: April 25, 2018
This is version 110 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome