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Q8L4P8

- CKB11_ORYSJ

UniProt

Q8L4P8 - CKB11_ORYSJ

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Protein

Cyclin-dependent kinase B1-1

Gene

CDKB1-1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei136 – 1361Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. RNA polymerase II carboxy-terminal domain kinase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_206303. G0 and Early G1.
REACT_221147. Senescence-Associated Secretory Phenotype (SASP).
REACT_221537. ERK1 activation.
REACT_225596. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_226419. G1/S-Specific Transcription.
REACT_235410. CDK-mediated phosphorylation and removal of Cdc6.
REACT_236852. E2F mediated regulation of DNA replication.
REACT_240160. Regulation of APC/C activators between G1/S and early anaphase.
REACT_249139. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
REACT_260847. Activation of the pre-replicative complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase B1-1 (EC:2.7.11.22, EC:2.7.11.23)
Short name:
CDKB1;1
Short name:
CDKB;1
Gene namesi
Name:CDKB1-1
Ordered Locus Names:Os01g0897000, LOC_Os01g67160
ORF Names:OsJ_04403, P0674H09.14, P0696G06.32
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBEP cladeEhrhartoideaeOryzeaeOryza
ProteomesiUP000000763: Chromosome 1

Organism-specific databases

GrameneiQ8L4P8.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 303303Cyclin-dependent kinase B1-1PRO_0000296098Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphothreonineBy similarity
Modified residuei15 – 151PhosphotyrosineBy similarity
Modified residuei170 – 1701PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Expressioni

Tissue specificityi

Expressed in actively dividing cells: root and shoot apical meristems, and young leaves.1 Publication

Inductioni

Down-regulated by sucrose starvation in suspension cell culture.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os01g67160.1.

Structurei

3D structure databases

ProteinModelPortaliQ8L4P8.
SMRiQ8L4P8. Positions 1-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 295292Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
HOGENOMiHOG000233024.
InParanoidiQ8L4P8.
OMAiRDWHEFP.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8L4P8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYEKLEKV GEGTYGKVYK AQDRATGQLV ALKKTRLEMD EEGIPPTALR
60 70 80 90 100
EISILRLLSQ SLYVVRLLSV EQATKNGKPV LYLVFEFLDT DLKKFVDAYR
110 120 130 140 150
KGPNPRPLPT NVIKSFLYQL CKGVAHCHGH GVLHRDLKPQ NLLVDKEKGI
160 170 180 190 200
LKIADLGLGR AFTVPMKSYT HEIVTLWYRA PEVLLGSTHY STGVDIWSVG
210 220 230 240 250
CIFAEMVRRQ ALFPGDSELQ QLLHIFRLLG TPTEEQWPGV TDLRDWHEFP
260 270 280 290 300
QWKPQILERQ VPSLEPEGVD LLSKMLQYNP ANRISAKAAM EHPYFDSLDK

SQF
Length:303
Mass (Da):34,602
Last modified:October 1, 2002 - v1
Checksum:i5AAAF71C0C1E281B
GO

Sequence cautioni

The sequence BAD82176.1 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence BAF06998.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB239918 mRNA. Translation: BAE93883.1.
AP003316 Genomic DNA. Translation: BAC06275.1.
AP003349 Genomic DNA. Translation: BAD82176.1. Sequence problems.
AP008207 Genomic DNA. Translation: BAF06998.1. Sequence problems.
CM000138 Genomic DNA. Translation: EEE55809.1.

Genome annotation databases

EnsemblPlantsiOS01T0897000-01; OS01T0897000-01; OS01G0897000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB239918 mRNA. Translation: BAE93883.1 .
AP003316 Genomic DNA. Translation: BAC06275.1 .
AP003349 Genomic DNA. Translation: BAD82176.1 . Sequence problems.
AP008207 Genomic DNA. Translation: BAF06998.1 . Sequence problems.
CM000138 Genomic DNA. Translation: EEE55809.1 .

3D structure databases

ProteinModelPortali Q8L4P8.
SMRi Q8L4P8. Positions 1-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 39947.LOC_Os01g67160.1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi OS01T0897000-01 ; OS01T0897000-01 ; OS01G0897000 .

Organism-specific databases

Gramenei Q8L4P8.

Phylogenomic databases

eggNOGi COG0515.
HOGENOMi HOG000233024.
InParanoidi Q8L4P8.
OMAi RDWHEFP.

Enzyme and pathway databases

Reactomei REACT_206303. G0 and Early G1.
REACT_221147. Senescence-Associated Secretory Phenotype (SASP).
REACT_221537. ERK1 activation.
REACT_225596. APC/C:Cdc20 mediated degradation of Cyclin B.
REACT_226419. G1/S-Specific Transcription.
REACT_235410. CDK-mediated phosphorylation and removal of Cdc6.
REACT_236852. E2F mediated regulation of DNA replication.
REACT_240160. Regulation of APC/C activators between G1/S and early anaphase.
REACT_249139. Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes.
REACT_260847. Activation of the pre-replicative complex.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of a rice cDNA encoding B1-type cyclin-dependent kinase."
    Sakaguchi N., Furukawa T., Shimada H., Hashimoto J., Sakaguchi K., Umeda M.
    Plant Biotechnol. 23:211-214(2006)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, INDUCTION.
    Strain: cv. Nipponbare.
  2. "The genome sequence and structure of rice chromosome 1."
    Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y., Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H., Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.
    , Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M., Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T., Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S., Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H., Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y., Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S., Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y., Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S., Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H., Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.
    Nature 420:312-316(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  4. "The rice annotation project database (RAP-DB): 2008 update."
    The rice annotation project (RAP)
    Nucleic Acids Res. 36:D1028-D1033(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENOME REANNOTATION.
    Strain: cv. Nipponbare.
  5. "The genomes of Oryza sativa: a history of duplications."
    Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S., Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.
    , Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J., Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X., Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y., Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L., Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H., Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z., Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L., Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F., Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q., Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J., Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M., McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.
    PLoS Biol. 3:266-281(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Nipponbare.
  6. "Genome-wide identification and expression analysis of rice cell cycle genes."
    Guo J., Song J., Wang F., Zhang X.S.
    Plant Mol. Biol. 64:349-360(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY.

Entry informationi

Entry nameiCKB11_ORYSJ
AccessioniPrimary (citable) accession number: Q8L4P8
Secondary accession number(s): B9EVC5, Q0JGY0, Q5N8M3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3