ID   HKT23_ORYSJ             Reviewed;         509 AA.
AC   Q8L481; Q0JM66;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   24-JAN-2024, entry version 89.
DE   RecName: Full=Probable cation transporter HKT2;3 {ECO:0000303|PubMed:16809061};
DE            Short=OsHKT2;3 {ECO:0000303|PubMed:16809061};
DE   AltName: Full=Probable cation transporter HKT3 {ECO:0000303|PubMed:12795699};
DE            Short=OsHKT3 {ECO:0000303|PubMed:12795699};
GN   Name=HKT2;3 {ECO:0000303|PubMed:16809061};
GN   Synonyms=HKT3 {ECO:0000303|PubMed:12795699};
GN   OrderedLocusNames=Os01g0532600 {ECO:0000312|EMBL:BAS72520.1},
GN   LOC_Os01g34850 {ECO:0000305};
GN   ORFNames=OJ1619_F12.15 {ECO:0000312|EMBL:BAD87687.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND NOMENCLATURE.
RC   STRAIN=cv. Nipponbare; TISSUE=Shoot;
RX   PubMed=12795699; DOI=10.1046/j.1365-313x.2003.01764.x;
RA   Garciadeblas B., Senn M.E., Banuelos M.A., Rodriguez-Navarro A.;
RT   "Sodium transport and HKT transporters: the rice model.";
RL   Plant J. 34:788-801(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12447438; DOI=10.1038/nature01184;
RA   Sasaki T., Matsumoto T., Yamamoto K., Sakata K., Baba T., Katayose Y.,
RA   Wu J., Niimura Y., Cheng Z., Nagamura Y., Antonio B.A., Kanamori H.,
RA   Hosokawa S., Masukawa M., Arikawa K., Chiden Y., Hayashi M., Okamoto M.,
RA   Ando T., Aoki H., Arita K., Hamada M., Harada C., Hijishita S., Honda M.,
RA   Ichikawa Y., Idonuma A., Iijima M., Ikeda M., Ikeno M., Ito S., Ito T.,
RA   Ito Y., Ito Y., Iwabuchi A., Kamiya K., Karasawa W., Katagiri S.,
RA   Kikuta A., Kobayashi N., Kono I., Machita K., Maehara T., Mizuno H.,
RA   Mizubayashi T., Mukai Y., Nagasaki H., Nakashima M., Nakama Y.,
RA   Nakamichi Y., Nakamura M., Namiki N., Negishi M., Ohta I., Ono N., Saji S.,
RA   Sakai K., Shibata M., Shimokawa T., Shomura A., Song J., Takazaki Y.,
RA   Terasawa K., Tsuji K., Waki K., Yamagata H., Yamane H., Yoshiki S.,
RA   Yoshihara R., Yukawa K., Zhong H., Iwama H., Endo T., Ito H., Hahn J.H.,
RA   Kim H.-I., Eun M.-Y., Yano M., Jiang J., Gojobori T.;
RT   "The genome sequence and structure of rice chromosome 1.";
RL   Nature 420:312-316(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16809061; DOI=10.1016/j.tplants.2006.06.001;
RA   Platten J.D., Cotsaftis O., Berthomieu P., Bohnert H., Davenport R.J.,
RA   Fairbairn D.J., Horie T., Leigh R.A., Lin H.X., Luan S., Maeser P.,
RA   Pantoja O., Rodriguez-Navarro A., Schachtman D.P., Schroeder J.I.,
RA   Sentenac H., Uozumi N., Very A.A., Zhu J.K., Dennis E.S., Tester M.;
RT   "Nomenclature for HKT transporters, key determinants of plant salinity
RT   tolerance.";
RL   Trends Plant Sci. 11:372-374(2006).
CC   -!- FUNCTION: Probable cation transporter. May be involved in regulation of
CC       potassium-sodium homeostasis. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- DOMAIN: HKT transporters are proposed to contain 4 pore-forming regions
CC       enclosed by transmembrane segments with each containing a potassium
CC       channel-like selectivity filter motif. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the TrkH potassium transport family. HKT
CC       (TC 2.A.38.3) subfamily. {ECO:0000305}.
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DR   EMBL; AJ491819; CAD37186.1; -; Genomic_DNA.
DR   EMBL; AJ491820; CAD37187.1; -; mRNA.
DR   EMBL; AP003447; BAD87687.1; -; Genomic_DNA.
DR   EMBL; AP008207; BAF05162.1; -; Genomic_DNA.
DR   EMBL; AP014957; BAS72520.1; -; Genomic_DNA.
DR   RefSeq; XP_015632753.1; XM_015777267.1.
DR   AlphaFoldDB; Q8L481; -.
DR   SMR; Q8L481; -.
DR   BioGRID; 796841; 1.
DR   STRING; 39947.Q8L481; -.
DR   PaxDb; 39947-Q8L481; -.
DR   EnsemblPlants; Os01t0532600-00; Os01t0532600-00; Os01g0532600.
DR   GeneID; 4327804; -.
DR   Gramene; Os01t0532600-00; Os01t0532600-00; Os01g0532600.
DR   KEGG; osa:4327804; -.
DR   eggNOG; KOG1341; Eukaryota.
DR   HOGENOM; CLU_008384_2_0_1; -.
DR   InParanoid; Q8L481; -.
DR   OMA; CHEKAYN; -.
DR   OrthoDB; 1017492at2759; -.
DR   Proteomes; UP000000763; Chromosome 1.
DR   Proteomes; UP000059680; Chromosome 1.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0098662; P:inorganic cation transmembrane transport; IEA:UniProt.
DR   GO; GO:0030001; P:metal ion transport; IEA:UniProt.
DR   InterPro; IPR003445; Cat_transpt.
DR   PANTHER; PTHR31064:SF11; CATION TRANSPORTER HKT9-RELATED; 1.
DR   PANTHER; PTHR31064; POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED; 1.
DR   Pfam; PF02386; TrkH; 2.
DR   Genevisible; Q8L481; OS.
PE   2: Evidence at transcript level;
KW   Ion transport; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..509
FT                   /note="Probable cation transporter HKT2;3"
FT                   /id="PRO_0000070468"
FT   TOPO_DOM        1..32
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        33..53
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        96..116
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        117..164
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        165..185
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        237..257
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        258..296
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        297..317
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        353..373
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        374..400
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        401..421
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        474..494
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        495..509
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   509 AA;  56374 MW;  A620A676B6F34A0F CRC64;
     MPIRLHIFVN SARHAINSSA FICRFIAYHL SPLLIHLSYF LIIDILGFVS LVVLRPSNHK
     YNPRYVDMFF LSTSAVTVIG LATIQMEDLS SSQIAILTLL MFLDSKMFLS FLGLVLESSK
     QNKHDPENRR VSSVTVCKQS QLEEATPQTP SMNSIDIKKR CLKYLVFVVL AYMIIILVTG
     SLLVFMYIAH VSSARDVLTR KSINKALFSI SVTVSSFTNG GLLPTNESMV VFSSNNGLLL
     LLIGQILAGS TLFPVFLRLV IWALRGLRLA KAEEPDFMMN NSSAVGFSHL LPNLQTIFLA
     VVEVAFVAMT VILFCCLNWD SVVFAGLSSL QKITNALFMA VNARQAGENS IDCSLVAPAA
     LVLFMVMMYT PSLTKLFSAC QDHKRIGPES DDRTSKGKPF LKMMAFSPLG FNTTVIMLVC
     ITERRSLSTD PLNLSTFNII FEVISAYGNI GLSTGYSCSR QLQHQEGIAC HEKAYNFSGW
     WSEPGKLILV LAMLCGRLNS KDSTSARTR
//