Q8L2I5 (PROD2_BACNA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Proline dehydrogenase 2 Short name=PRODH 2 EC=1.5.99.8 Alternative name(s): Proline oxidase 2
Organism	Bacillus subtilis subsp. natto
Taxonomic identifier	86029 [NCBI]
Taxonomic lineage	Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the oxidation of L-proline to delta-1-pyrroline-5-carboxylate (P5C) By similarity.
Catalytic activity	L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor.
Cofactor	FAD By similarity.
Pathway	Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Sequence similarities	Belongs to the proline dehydrogenase family.

Ontologies

Keywords
Biological process	Proline metabolism
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	glutamate biosynthetic process Inferred from electronic annotation. Source: InterPro proline catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	proline dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	Proline dehydrogenase 2		PRO_0000361668

Sequences

	Sequence		Length	Mass (Da)
	Q8L2I5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: E748D9A7E0FD731B	FASTA	304	35,143
	10 20 30 40 50 60 MVITRDFFLF LSKSGFLNKM ARNWGSRIAA GKIIGGNDFN SSIPTIRQLN SQGLSVTVDH 70 80 90 100 110 120 LGEFVNSAEV ARERTEECIQ TIATIADQEL NSHVSLKMTS LGLDIDMDLV YENMTKILQT 130 140 150 160 170 180 AEKHKIMVTI DMEDEVRCQK TLDIFKDFRK KYEHVSTVLQ AYLYRTEKDI DDLDSLNPFL 190 200 210 220 230 240 RLVKGAYKES EKVAFPEKSD VDENYKKIIR KQLLNGHYTA IATHDDKMID FTKQLAKEHG 250 260 270 280 290 300 IANDKFEFQM LYGMRSQTQL SLVKEGYNMR VFLPYGEDWY GYFMRRLAER PSNIAFAFKG MTKK

References

[1]	Chang G.-N., Yeh C.-H., Huang T.-C. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: CCRC 14716.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503437 Genomic DNA. Translation: AAM27443.1.
3D structure databases
ProteinModelPortal	Q8L2I5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR002872. Proline_DH. IPR008219. Proline_DH_prd. [Graphical view]
Pfam	PF01619. Pro_dh. 1 hit. [Graphical view]
PIRSF	PIRSF000196. Pro_dehydrog. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PROD2_BACNA

Accession

Primary (citable) accession number: Q8L2I5

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 1, 2002
Last modified:	September 21, 2011
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program