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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.UniRule annotation
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. no protein annotated in this organism
  4. Fructose-bisphosphate aldolase (fbaB)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei363Proton donorUniRule annotation1
Active sitei394UniRule annotation1
Active sitei523UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomeraseUniRule annotation (EC:5.3.1.9UniRule annotation)
Short name:
GPIUniRule annotation
Alternative name(s):
Phosphoglucose isomeraseUniRule annotation
Short name:
PGIUniRule annotation
Phosphohexose isomeraseUniRule annotation
Short name:
PHIUniRule annotation
Gene namesi
Name:pgiUniRule annotation
Ordered Locus Names:BH01370
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001805981 – 559Glucose-6-phosphate isomeraseAdd BLAST559

Proteomic databases

PaxDbiQ8L1Z9.
PRIDEiQ8L1Z9.

Interactioni

Protein-protein interaction databases

STRINGi283166.BH01370.

Structurei

3D structure databases

ProteinModelPortaliQ8L1Z9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiKMTEWGI.
OrthoDBiPOG091H04C3.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8L1Z9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRYKSMGDSL SIRNEKAFEA ALQALRRHAI KDGVYDIRRH FIEDEQRFSN
60 70 80 90 100
FSLNLDDFLF DFSKCGVTFK TLQLLDDLAV AADVLGRRDA MFSGKAINTT
110 120 130 140 150
EKRSVLHIAL RLPADEVFML DGTDLVHDIQ GVLADMERFS DMVRDGSYKG
160 170 180 190 200
NSGEKIIDIV NIGIGGSDLG PAMVTYALKP YHDGPNCHFV SNADSAHISD
210 220 230 240 250
TLSVLNPATT LFVIASKTFT TAETIANAQV ARQWIMSHLG KEAVCKHFIA
260 270 280 290 300
VSSALDKVAE FGIDSSRTFR FWDWVGGRYS IWSAIGLVVM LAIGGQNFRQ
310 320 330 340 350
FLEGAQHMDR HFKTAPLRKN IPIRFALLGF WHRVVCGYAS RAVIPYAQRL
360 370 380 390 400
ARFPAYLQQL DMESNGKQVS LDGKTLTFSS GPVVWGDSGT NGQHAFFQLL
410 420 430 440 450
HQGTDVIPVE FILFIKGHEQ NLHPMYDMLV ANCLAQSKAL MKGRSVEDAR
460 470 480 490 500
RMLLKSGIDE RESENLALHK SFAGNRPNMM LVQDLLTPFA LGRLIALYEH
510 520 530 540 550
RIFVEGILMN INSFDQWGVE LGKELANELL PILRGENKTN NRDSSTLGLL

AHIQARRGE
Length:559
Mass (Da):62,489
Last modified:October 1, 2002 - v1
Checksum:i6064CB7C96CAC459
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074771 Genomic DNA. Translation: AAL74284.1.
BX897699 Genomic DNA. Translation: CAF26951.1.

Genome annotation databases

EnsemblBacteriaiCAF26951; CAF26951; BH01370.
KEGGibhe:BH01370.
PATRICi20544001. VBIBarHen29080_0159.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074771 Genomic DNA. Translation: AAL74284.1.
BX897699 Genomic DNA. Translation: CAF26951.1.

3D structure databases

ProteinModelPortaliQ8L1Z9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi283166.BH01370.

Proteomic databases

PaxDbiQ8L1Z9.
PRIDEiQ8L1Z9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAF26951; CAF26951; BH01370.
KEGGibhe:BH01370.
PATRICi20544001. VBIBarHen29080_0159.

Phylogenomic databases

eggNOGiENOG4107QP8. Bacteria.
COG0166. LUCA.
HOGENOMiHOG000261370.
KOiK01810.
OMAiKMTEWGI.
OrthoDBiPOG091H04C3.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase. 1 hit.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiG6PI_BARHE
AccessioniPrimary (citable) accession number: Q8L1Z9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.