Q8L1Z8 (PGK_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglycerate kinase
EC=2.7.2.3

Gene names

Name:	pgk
Ordered Locus Names:	BH15070

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella › Bartonella henselae

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoglycerate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	Phosphoglycerate kinase HAMAP-Rule MF_00145		PRO_0000145907
Regions
	Nucleotide binding	353 – 356	4	ATP By similarity
	Region	21 – 23	3	Substrate binding By similarity
	Region	59 – 62	4	Substrate binding By similarity
Sites
	Binding site	36	1	Substrate By similarity
	Binding site	118	1	Substrate By similarity
	Binding site	151	1	Substrate By similarity
	Binding site	201	1	ATP By similarity
	Binding site	323	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8L1Z8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9CBB50173FE98508	FASTA	397	42,617
	10 20 30 40 50 60 MGFRTLDDVD VTGKRVLVRV DFNVPMAQGK VCDDTRLKRH KETLLELQKR GAKLILLSHC 70 80 90 100 110 120 GRPKGQVEPE FSLHPVVQVL EKIINQPVNF ASDCIGVAVQ TAVEALQNGG ILLLENVRFH 130 140 150 160 170 180 SGEEKNAGSF AEALAHNGDL YVNDAFSVSH RAHASVEGIT HFLPSYAGRS LQCELQALEK 190 200 210 220 230 240 GLGKPERPVI AIVGGAKVSS KLFVLNHLVK KVDYLVIGGG MANSFLAAQG VCVGKSLCEH 250 260 270 280 290 300 ALIETVKKVI EKARECQCTL LLPVDAIVGF RFEKDAPHRL YDIGDIPEDG MILDVGTRSI 310 320 330 340 350 360 AHINAVIDKA ATLVWNGPLG VFEMSPFDQG TIAVARHAAE LSLTGKLVSI AGGGDTVFAL 370 380 390 NHAGVADDFT YLSTAGGAFL EWMEGKMLPG ILALTQA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The global phylogeny of glycolytic enzymes." Canback B., Andersson S.G.E., Kurland C.G. Proc. Natl. Acad. Sci. U.S.A. 99:6097-6102(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.
[2]	"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY074772 Genomic DNA. Translation: AAL74285.1. BX897699 Genomic DNA. Translation: CAF28270.1.
RefSeq	YP_034205.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q8L1Z8.
ModBase	Search...
Protein-protein interaction databases
STRING	283166.BH15070.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF28270; CAF28270; BH15070.
GeneID	2865020.
KEGG	bhe:BH15070.
PATRIC	20547250. VBIBarHen29080_1733.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0126.
HOGENOM	HOG000227107.
KO	K00927.
OMA	EKKNDEA.
ProtClustDB	PRK00073.
Enzyme and pathway databases
BioCyc	BHEN283166:GIVZ-1502-MONOMER.
UniPathway	UPA00109; UER00185.
Family and domain databases
Gene3D	3.40.50.1260. 1 hit. 3.40.50.1270. 1 hit.
HAMAP	MF_00145. Phosphoglyc_kinase.
InterPro	IPR001576. Phosphoglycerate_kinase. IPR015901. Phosphoglycerate_kinase_C. IPR015911. Phosphoglycerate_kinase_CS. IPR015824. Phosphoglycerate_kinase_N. [Graphical view]
PANTHER	PTHR11406. PTHR11406. 1 hit.
Pfam	PF00162. PGK. 1 hit. [Graphical view]
PIRSF	PIRSF000724. Pgk. 1 hit.
PRINTS	PR00477. PHGLYCKINASE.
SUPFAM	SSF53748. PGK. 1 hit.
PROSITE	PS00111. PGLYCERATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGK_BARHE

Accession

Primary (citable) accession number: Q8L1Z8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program