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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Bartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pykA)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei118SubstrateUniRule annotation1
Binding sitei151SubstrateUniRule annotation1
Binding sitei201ATPUniRule annotation1
Binding sitei323ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi353 – 356ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:BH15070
OrganismiBartonella henselae (strain ATCC 49882 / DSM 28221 / Houston 1) (Rochalimaea henselae)
Taxonomic identifieri283166 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000000421 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001459071 – 397Phosphoglycerate kinaseAdd BLAST397

Proteomic databases

PaxDbiQ8L1Z8
PRIDEiQ8L1Z8

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi283166.BH15070

Structurei

3D structure databases

ProteinModelPortaliQ8L1Z8
SMRiQ8L1Z8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

Gene3Di3.40.50.1260, 3 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8L1Z8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGFRTLDDVD VTGKRVLVRV DFNVPMAQGK VCDDTRLKRH KETLLELQKR
60 70 80 90 100
GAKLILLSHC GRPKGQVEPE FSLHPVVQVL EKIINQPVNF ASDCIGVAVQ
110 120 130 140 150
TAVEALQNGG ILLLENVRFH SGEEKNAGSF AEALAHNGDL YVNDAFSVSH
160 170 180 190 200
RAHASVEGIT HFLPSYAGRS LQCELQALEK GLGKPERPVI AIVGGAKVSS
210 220 230 240 250
KLFVLNHLVK KVDYLVIGGG MANSFLAAQG VCVGKSLCEH ALIETVKKVI
260 270 280 290 300
EKARECQCTL LLPVDAIVGF RFEKDAPHRL YDIGDIPEDG MILDVGTRSI
310 320 330 340 350
AHINAVIDKA ATLVWNGPLG VFEMSPFDQG TIAVARHAAE LSLTGKLVSI
360 370 380 390
AGGGDTVFAL NHAGVADDFT YLSTAGGAFL EWMEGKMLPG ILALTQA
Length:397
Mass (Da):42,617
Last modified:October 1, 2002 - v1
Checksum:i9CBB50173FE98508
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY074772 Genomic DNA Translation: AAL74285.1
BX897699 Genomic DNA Translation: CAF28270.1

Genome annotation databases

EnsemblBacteriaiCAF28270; CAF28270; BH15070
KEGGibhe:BH15070

Similar proteinsi

Entry informationi

Entry nameiPGK_BARHE
AccessioniPrimary (citable) accession number: Q8L1Z8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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