Q8L1Z7 (GPMA_BARHE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase
Short name=BPG-dependent PGAM
Short name=PGAM
Short name=Phosphoglyceromutase
Short name=dPGM
EC=5.4.2.1

Gene names

Name:	gpmA
Synonyms:	pgm
Ordered Locus Names:	BH12450

Organism

Bartonella henselae (strain ATCC 49882 / Houston 1) (Rochalimaea henselae) [Complete proteome] [HAMAP]

Taxonomic identifier

283166 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Bartonellaceae › Bartonella › Bartonella henselae

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01039
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01039
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01039
Sequence similarities	Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: HAMAP
Molecular_function	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	2,3-bisphosphoglycerate-dependent phosphoglycerate mutase HAMAP-Rule MF_01039		PRO_0000179848
Sites
	Active site	10	1	Tele-phosphohistidine intermediate By similarity
	Active site	158	1	By similarity
	Site	61	1	Interaction with carboxyl group of phosphoglycerates By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8L1Z7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F2AA8D379630D994	FASTA	206	23,252
	10 20 30 40 50 60 MERTLVLIRH GQSEWNLKNL FTGWKDPGLT EKGRTEAIAA GKKLKETGLK FDIAYTSALQ 70 80 90 100 110 120 RAQKTAQNIL EQMEQSDLEL IKTPALNERN YGDLSGLNKD EVRQKWGEQQ VQIWRRSYTI 130 140 150 160 170 180 APPNGESLRD TGARVWPYYL HHIQPHILRS QTVLIAAHGN SLRALIMALE GLNSEEIISQ 190 200 ELATGIPIVY TFNSDSTISS KTIITP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The global phylogeny of glycolytic enzymes." Canback B., Andersson S.G.E., Kurland C.G. Proc. Natl. Acad. Sci. U.S.A. 99:6097-6102(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.
[2]	"The louse-borne human pathogen Bartonella quintana is a genomic derivative of the zoonotic agent Bartonella henselae." Alsmark U.C.M., Frank A.C., Karlberg E.O., Legault B.-A., Ardell D.H., Canbaeck B., Eriksson A.-S., Naeslund A.K., Handley S.A., Huvet M., La Scola B., Holmberg M., Andersson S.G.E. Proc. Natl. Acad. Sci. U.S.A. 101:9716-9721(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49882 / Houston 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY074773 Genomic DNA. Translation: AAL74286.1. BX897699 Genomic DNA. Translation: CAF28027.1.
RefSeq	YP_033999.1. NC_005956.1.
3D structure databases
ProteinModelPortal	Q8L1Z7.
SMR	Q8L1Z7. Positions 5-204.
ModBase	Search...
Protein-protein interaction databases
STRING	283166.BH12450.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAF28027; CAF28027; BH12450.
GeneID	2865050.
KEGG	bhe:BH12450.
PATRIC	20546369. VBIBarHen29080_1314.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0588.
HOGENOM	HOG000221682.
KO	K01834.
OMA	GQSDWNL.
ProtClustDB	PRK01295.
Enzyme and pathway databases
BioCyc	BHEN283166:GIVZ-1240-MONOMER.
UniPathway	UPA00109; UER00186.
Family and domain databases
HAMAP	MF_01039. PGAM_GpmA.
InterPro	IPR013078. His_Pase_superF_clade-1. IPR001345. PG/BPGM_mutase_AS. IPR005952. Phosphogly_mut1. [Graphical view]
PANTHER	PTHR11931. PTHR11931. 1 hit.
Pfam	PF00300. His_Phos_1. 1 hit. [Graphical view]
SMART	SM00855. PGAM. 1 hit. [Graphical view]
TIGRFAMs	TIGR01258. pgm_1. 1 hit.
PROSITE	PS00175. PG_MUTASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GPMA_BARHE

Accession

Primary (citable) accession number: Q8L1Z7

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 13, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program