Q8KY03 (Q8KY03_MYCPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine dehydrogenase PIRNR PIRNR000183
EC=1.4.1.1 PIRNR PIRNR000183

Gene names

Name:	ald EMBL AAM44190.1
Ordered Locus Names:	MAP_2888

Organism

Mycobacterium paratuberculosis [Complete proteome] [HAMAP] EMBL AAM44190.1

Taxonomic identifier

1770 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC)

Protein attributes

Sequence length	373 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH. PIRNR PIRNR000183
Pathway	Amino-acid degradation; L-alanine degradation via dehydrogenase pathway; NH(3) and pyruvate from L-alanine: step 1/1. PIRNR PIRNR000183
Sequence similarities	Belongs to the AlaDH/PNT family. PIRNR PIRNR000183

Ontologies

Keywords
Ligand	NAD PIRNR PIRNR000183
Molecular function	Oxidoreductase PIRNR PIRNR000183 EMBL AAM44190.1
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	alanine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KY03 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D5A1B9CB7A519C98	FASTA	373	38,904
	10 20 30 40 50 60 MRVGVPTETK TNEFRVALTP AGVAELTRRG HEVLVQSGAG EGSSIPDSEF KAAGAQLADT 70 80 90 100 110 120 AEQVWADAEL LLKVKEPVPA EYDLLRRNQI LFTFLHLAAS RACTEALLTS GTTSIAYETV 130 140 150 160 170 180 QTADGTLPLL APMSEVAGRL SAQVGAYHLM RTHGGRGVLM GGVPGVKPAD VVVVGAGTAG 190 200 210 220 230 240 YNAARVAGGM GAMVTVLDVN INKLRLLDAE FGGQVRTRYS SAYDLEGTVK RADLVIGAVL 250 260 270 280 290 300 LPGAKAPNLI SNSLVAQMKS GAVLVDISID QGGCFEDSRP TTHDDPTFAV HDTVFYCVAN 310 320 330 340 350 360 MPSAVPKTST VALTNATMPY VLALADRGWR AACRSNHALA KGLSTHDGAL LSQQVAADLG 370 LPCTDPAGVL QQD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Mycobacterium avium subspecies paratuberculosis." Li L., Bannantine J.P., Zhang Q., Amonsin A., May B.J., Alt D., Banerji N., Kanjilal S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 102:12344-12349(2005) [PubMed: 16116077] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-968 / K-10.
[2]	"Cloning and characterization of a L-alanine dehydrogenase from Mycobacterium avium subsp. paratuberculosis." Zabaleta J., Feng Z., Barletta R.G. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: K-10 EMBL AAM44190.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF322643 Genomic DNA. Translation: AAM44190.1. AE016958 Genomic DNA. Translation: AAS05205.1.
RefSeq	NP_961822.1. NC_002944.2.
3D structure databases
HSSP	HSSP built from PDB template 1SAY based on UniProtKB O52942.
ProteinModelPortal	Q8KY03.
SMR	Q8KY03. Positions 1-370.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBMYCT00000037400; EBMYCP00000035789; EBMYCG00000037395.
GeneID	2719820.
GenomeReviews	Gene locus MAP_2888 in contig AE016958_GR.
KEGG	mpa:MAP2888.
NMPDR	fig|262316.1.peg.2888.
PATRIC	17998500. VBIMycAvi108102_3060.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000016024.
HOGENOM	HBG289735.
OMA	VAHGHEV.
ProtClustDB	CLSK792072.
Family and domain databases
InterPro	IPR008142. Ala_DH/PNT_CS1. IPR008143. Ala_DH/PNT_CS2. IPR008141. Ala_DH/Pyr_transHydgase. IPR007886. AlaDH/PNT_N. IPR007698. AlaDH/PNT_NAD(H)-bd. [Graphical view]
KO	K00259.
PANTHER	PTHR10160:SF3. PTHR10160:SF3. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
PIRSF	PIRSF000183. Alanine_dh. 1 hit.
SMART	SM01002. AlaDh_PNT_C. 1 hit. SM01003. AlaDh_PNT_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00518. AlaDH. 1 hit.
PROSITE	PS00836. ALADH_PNT_1. 1 hit. PS00837. ALADH_PNT_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8KY03_MYCPA

Accession

Primary (citable) accession number: Q8KY03
Secondary accession number(s): Q73VX3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)