Q8KX40 (NU3C_SYNP2) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NAD(P)H-quinone oxidoreductase subunit 3
EC=1.6.5.-

Alternative name(s):
NAD(P)H dehydrogenase subunit 3
NADH-plastoquinone oxidoreductase subunit 3
NDH-1 subunit 3
Short name=NDH-C

Gene names

Name:	ndhC
Ordered Locus Names:	SYNPCC7002_A2748

Organism

Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum) [Complete proteome] [HAMAP]

Taxonomic identifier

32049 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechococcus

Protein attributes

Sequence length	120 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	NDH-1 shuttles electrons from an unknown electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and/or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon-concentration By similarity. HAMAP MF_01394
Catalytic activity	NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP MF_01394
Subunit structure	NDH-1 can be composed of about 15 different subunits; different subcomplexes with different compositions have been identified which probably have different functions By similarity.
Subcellular location	Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP MF_01394.
Sequence similarities	Belongs to the complex I subunit 3 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane Thylakoid
Domain	Transmembrane Transmembrane helix
Ligand	NAD NADP Plastoquinone
Molecular function	Oxidoreductase
PTM	Quinone
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW thylakoid membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	NADH dehydrogenase (ubiquinone) activity Inferred from electronic annotation. Source: InterPro quinone binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 120	120	NAD(P)H-quinone oxidoreductase subunit 3 HAMAP MF_01394		PRO_0000362788
Regions
	Transmembrane	2 – 22	21	Helical; Potential
	Transmembrane	64 – 84	21	Helical; Potential
	Transmembrane	89 – 109	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KX40 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: B4107974C05F7159	FASTA	120	13,526
	10 20 30 40 50 60 MFVLSGYEYF LGFLIVSSLV PILALTASKL LRPKGGGPER KTTYESGMEP IGGAWIQFNI 70 80 90 100 110 120 RYYMFALVFV VFDVETVFLY PWAVAFNQLG LLAFVEALIF IAILVIALVY AWRKGALEWS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An analysis of forty genes encoding electron transport proteins from Synechococcus sp. PCC 7002: a comparative study of electron transport Proteins from cyanobacteria and chloroplasts." Nomura C.T., Persson S., Zhao J., Bryant D.A. Submitted (MAY-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete sequence of Synechococcus sp. PCC 7002." Li T., Zhao J., Zhao C., Liu Z., Zhao F., Marquardt J., Nomura C.T., Persson S., Detter J.C., Richardson P.M., Lanz C., Schuster S.C., Wang J., Li S., Huang X., Cai T., Yu Z., Luo J., Zhao J., Bryant D.A. Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27264 / PCC 7002 / PR-6.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF381040 Genomic DNA. Translation: AAN03553.1. CP000951 Genomic DNA. Translation: ACB00722.1.
RefSeq	YP_001735977.1. NC_010475.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q8KX40.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	6056367.
GenomeReviews	Gene locus SYNPCC7002_A2748 in contig CP000951_GR.
KEGG	syp:SYNPCC7002_A2748.
PATRIC	23820164. VBISynSp37135_3008.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG605540.
OMA	GERELTY.
PhylomeDB	Q8KX40.
ProtClustDB	PRK06602.
Family and domain databases
HAMAP	MF_01394. NDH1_NuoA. [Tree]
InterPro	IPR023043. NAD(P)H_OxRDtase_bac/plastid. IPR000440. NADH_UbQ/plastoQ_OxRdtase_su3. [Graphical view]
KO	K05574.
PANTHER	PTHR11058. Oxidored_q4. 1 hit.
Pfam	PF00507. Oxidored_q4. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NU3C_SYNP2

Accession

Primary (citable) accession number: Q8KX40

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program