Q8KUI0 (Q8KUI0_ACTPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Cytochrome P450 EMBL AAM54108.1

Gene names

Name:

asm30 EMBL AAM54108.1

Organism

Actinosynnema pretiosum subsp. auranticum EMBL AAM54108.1

Taxonomic identifier

42198 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	1005 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Molecular function	FMN binding Inferred from electronic annotation. Source: InterPro NADPH-hemoprotein reductase activity Inferred from electronic annotation. Source: InterPro aromatase activity Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KUI0 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 647E9EDA09935708	FASTA	1,005	108,751
	10 20 30 40 50 60 MVATGTRIPG PKPLPLVGNL LDVLTSDLDT DVDFLDRCHR EHGGIVALTF AGQRQVFASS 70 80 90 100 110 120 HELVARMCSD PSWGKAVHPA LEQVRDFAGD GLFTARGDEP NWGKAHRLLM PAFGPTAMRD 130 140 150 160 170 180 HFPAMLDIAE QMLVRWRRFG PDHRIDVADD MTRLTLDTIA LCAFGARFNS FYRDRAHPFV 190 200 210 220 230 240 DAMVRSLVEA GERAERLPGV QPFLVGRNQR YRDDIATMNR IADGIVAARA ALPAGERPDD 250 260 270 280 290 300 LLERMLTCAD PVTGERLSAR NVRYQLATFL IAGHETTSGL LSFAVHRLLA HPEVLRKAKD 310 320 330 340 350 360 AVDGVLGDRV PAFEDLARLD YLGQVLRETL RLHPTAPAFA LAPDEPAELG GHAIGAGEPV 370 380 390 400 410 420 LVMLPTLHRD PAVWRDPDVF DPERFAPERM DEIPACAWMP FGHGARACIG RPFALQEATL 430 440 450 460 470 480 VLALVLQRFD LALADPDHRL TIKQTLTLKP DSLVVRARPR ADRPGATATV ETVVPHQVPA 490 500 510 520 530 540 THRHGTPLHV FYGSNGGSGE GLARTIAGDG AARGWATSVA PLDDAVRALP ASGPVVIVSS 550 560 570 580 590 600 SYNGAPPDNA AHFVRWLTQD GPDLSGVDYL VLGCGNLDWS ATYQRVPTLI DEAMAAAGAR 610 620 630 640 650 660 RLRERGATDA RADFFGDWER WYEPLWPLLS AECGVEVGEI GPRFRVVESD AADGLGDLAS 670 680 690 700 710 720 AVVLENRELV RGPDAGSKRH LELRLPDGTS YRTGDYLSVL PQNHPDLVRR AVARLGTRAE 730 740 750 760 770 780 RVVTVESSAP TGLVPVGRAL RVDELLTRCV DLSAPAGAGV VARLAERCPC PPERAELAAT 790 800 810 820 830 840 TGATLLELLE RFPSCAVDLA LALELLPAPR TRLYSISSAA EEQRAEVALT VSVTGVTSGY 850 860 870 880 890 900 LSRVRPGDRV AVGIASPPES FRPPADNTVP VVLIAAGTGI APFRGFLRAR AALGGEPGPA 910 920 930 940 950 960 LLLFGCRGPE LDDLYAEEFA ALGDWLEVDR AYSRHPDGEV RHVQHRLWQR RDRVRELVDA 970 980 990 1000 GARVYLCGDA TRVGPAVEEV LGRIGPGAGW LDALRAGGRY ATDVF

References

[1]	"The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum." Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002) [PubMed: 12060743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54108.1.
[2]	Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54108.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF453501 Genomic DNA. Translation: AAM54108.1.
3D structure databases
HSSP	HSSP built from PDB template 1JPZ based on UniProtKB P14779.
ProteinModelPortal	Q8KUI0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR023206. Bifunctional_P450_P450_red. IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR003097. FAD-binding_1. IPR017927. Fd_Rdtase_FAD-bd. IPR008254. Flavodoxin/NO_synth. IPR023173. NADPH_Cyt_P450_Rdtase_dom3. IPR001433. OxRdtase_FAD/NAD-bd. IPR017938. Riboflavin_synthase-like_b-brl. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit. G3DSA:1.20.990.10. NADPH_Cyt_P450_Rdtase_dom3. 1 hit.
Pfam	PF00667. FAD_binding_1. 1 hit. PF00258. Flavodoxin_1. 1 hit. PF00175. NAD_binding_1. 1 hit. PF00067. p450. 1 hit. [Graphical view]
PIRSF	PIRSF000209. Bifunctional_P450_P450R. 1 hit.
PRINTS	PR00463. EP450I. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit. SSF63380. Riboflavin_synthase_like_b-brl. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. PS51384. FAD_FR. 1 hit. PS50902. FLAVODOXIN_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8KUI0_ACTPA

Accession

Primary (citable) accession number: Q8KUI0

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	September 21, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)