Q8KUH1 (Q8KUH1_ACTPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
5-deoxy-5-amino-3-dehydroquinate dehydratase EMBL AAM54101.1

Gene names

Name:

asm23 EMBL AAM54101.1

Organism

Actinosynnema pretiosum subsp. auranticum EMBL AAM54101.1

Taxonomic identifier

42198 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	144 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

3-dehydroquinate = 3-dehydroshikimate + H2O. SAAS SAAS018509

Ontologies

Keywords
Molecular function	Lyase SAAS SAAS018509
Gene Ontology (GO)
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	23	1	Proton acceptor By similarity PIRSR PIRSR001399-1
	Active site	99	1	Proton donor By similarity PIRSR PIRSR001399-1
	Site	18	1	Transition state stabilizer By similarity PIRSR PIRSR001399-5

Sequences

	Sequence		Length	Mass (Da)
	Q8KUH1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 6A3807011ECFEAB4	FASTA	144	15,381
	10 20 30 40 50 60 MPDLLLLNGP NLGILGRREP EVYGTATLAD IEDAVADEVA DRGWKVVARQ HDGEAEMIGT 70 80 90 100 110 120 IQDSYDTVGA IVNPGALMIA GWSLRDALAN YPSPWIEVHL SNVWAREPFR HQSVIAPLAT 130 140 GLIAGVGALG YRLAARALLD RVGG

References

[1]	"The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum." Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002) [PubMed: 12060743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54101.1.
[2]	Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54101.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF453501 Genomic DNA. Translation: AAM54101.1.
3D structure databases
HSSP	HSSP built from PDB template 1UQR based on UniProtKB P43877.
ProteinModelPortal	Q8KUH1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
HAMAP	MF_00169. AroQ. [Tree]
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.9100. DHquinase_II. 1 hit.
PANTHER	PTHR21272. DHquinase_II. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8KUH1_ACTPA

Accession

Primary (citable) accession number: Q8KUH1

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	December 14, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)