Q8KUF5 (Q8KUF5_ACTPA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Polyketide synthase EMBL AAM54077.1

Gene names

Name:

asmC EMBL AAM54077.1

Organism

Actinosynnema pretiosum subsp. auranticum EMBL AAM54077.1

Taxonomic identifier

42198 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Pseudonocardineae › Actinosynnemataceae › Actinosynnema

Protein attributes

Sequence length	1589 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Keywords
Ligand	Phosphopantetheine RuleBase RU000721
Molecular function	Transferase RuleBase RU000693
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	acyl carrier activity Inferred from electronic annotation. Source: InterPro cofactor binding Inferred from electronic annotation. Source: InterPro nucleotide binding Inferred from electronic annotation. Source: InterPro oxidoreductase activity Inferred from electronic annotation. Source: InterPro phosphopantetheine binding Inferred from electronic annotation. Source: InterPro transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KUF5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5067CF9A772A525F	FASTA	1,589	164,713
	10 20 30 40 50 60 MTDGTHEKLV DYLRWVTADL HETRRKLADL ESAGHEPIAI TGLACRAPGG VRTPEALWEL 70 80 90 100 110 120 VDGGVDAITG FPTDRGWDLA GLYDPDPTRP GTCYTREGGF LHDAAEFDAG FFGIGPREAV 130 140 150 160 170 180 TIDPQHRMLL ETSWEAVERA GLDPLSLRGT GTGVFSGVVY QNYGNRRRVA EEFEGHLAIG 190 200 210 220 230 240 SSGSVASGRV AYALGLHGPA ITVDTACSSS LVAIHLAAQS LRRGECAMAL AGGATVMPLS 250 260 270 280 290 300 DVFVEFARQR GLSPDGRCKA FSADADGTAW GEGVGVVLLE RLSDARRAGR PVLAVIRGSA 310 320 330 340 350 360 VNSDGASNGL TAPNGAAQQR VIEAALEDAG LRPSDVDLLE AHGTGTRLGD PIEAAALQAT 370 380 390 400 410 420 YGRARPEGRP LLLGSLKSNI GHAQGAAGVL GLVKVVQALR HGVAPRTLHA DRLTPEVDWT 430 440 450 460 470 480 SGALRVLTEP APWPRGERPR RAAVSAFGMS GTNAHLVVEE GDAPSAPGER RPAGALPLLL 490 500 510 520 530 540 SARGGAALRA AAADLVELPG EPVDVCWSLL TGRARLVDRA VVVAADRAGF TAGLEALAAD 550 560 570 580 590 600 RPSAAAVTGR ADVAGRTVLV FPGQGGQWVG MGARLLDESP VFAAAVARCA AAVEPLVDFR 610 620 630 640 650 660 VVDALRGGDL GRVDVVQPVS FVLMVALARL WRSVGVEPDV VVGHSQGEIA AACVAGALSL 670 680 690 700 710 720 EDAARVVVLR SRAIAAEAGG GGMASIPLPR AEVERLITGT GVSVAAVNGP GSVVVSGDVD 730 740 750 760 770 780 PLVARVEGAR RLPVDYASHS PAVDVLRGRL LADLARVTPR PAAIPMLSTV TGKWLDGAEL 790 800 810 820 830 840 DADYWFANLR EPVRFADAVT ELAGADCAAF VEVGAHPVLT AAIQDVLGER TAVVTGTLRR 850 860 870 880 890 900 DDGGLDRFLR SAAALHVRGV PVDWAPVFEG LDARRADLPT YPFQRARHWL QEAEPDARQA 910 920 930 940 950 960 GGDDPLWAAA RDADGLCAEL ELTEPDQRAA LRAVLPALTA WHERRSERAL LDSWRYRITW 970 980 990 1000 1010 1020 RTLPEPPESA PRGDWLVVGP HPDLLADLLP GAALDPGDAD RAALADLLRP HTAVAGVLAT 1030 1040 1050 1060 1070 1080 PGADVLTLVQ ALGDAGATAP LWCATTGAVA ISPHDGPPDP AQAATWGLGR VVALEHPGRW 1090 1100 1110 1120 1130 1140 GGLVDLADPA DPRQRRGLAA VLAGPGVDDG GEDQVAIRAQ GVFARRLVRA EPQAPAAPWT 1150 1160 1170 1180 1190 1200 PRGTVLITGG TGGVAAHVAR RLAALGADHL VLTSRRGPSA PGAPALAADL EALGARVTTA 1210 1220 1230 1240 1250 1260 ACDVADRAAL AALLTGLERA GEQVTAVVHA AGANAQTPVA DTTPEEHARV QAAKALGAEH 1270 1280 1290 1300 1310 1320 LDELLGGRPL DAFVLFSSNA GVWGSGGQCA YAAANARLDA LAQRRRAHGR VATSVAWGAW 1330 1340 1350 1360 1370 1380 DGGGMSSATP DIAAQLAQAG LRLMPPDLAV SALLDAVARD ESTTVVTDVR WEAFAARFTA 1390 1400 1410 1420 1430 1440 LRRSPLLADL PEARPEPVAA TAEPDRGLAG ELAALPAPER LRRLTDLVRA HAAAALGHPG 1450 1460 1470 1480 1490 1500 PESVPADVAF RDLGVDSLAA VELRNRACAA TGAKLTPTAV FDHPTPRALA EHLAEHLAAA 1510 1520 1530 1540 1550 1560 RDSAAPDAAP DAEDPTSALR DLDALAAALP AAAGDDALRE RVTARLREVL GRWEELTGGP 1570 1580 GGPDDLDLDH ISDDELFRLA DSRLGPTGA

References

[1]	"The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum." Yu T.W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Proc. Natl. Acad. Sci. U.S.A. 99:7968-7973(2002) [PubMed: 12060743] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54077.1.
[2]	Yu T.-W., Bai L., Clade D., Hoffmann D., Toelzer S., Trinh K.Q., Xu J., Moss S.J., Leistner E., Floss H.G. Submitted (NOV-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: ATCC 31565 EMBL AAM54077.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF453501 Genomic DNA. Translation: AAM54077.1.
3D structure databases
HSSP	HSSP built from PDB template 1NQ4 based on UniProtKB P43677.
ProteinModelPortal	Q8KUF5.
SMR	Q8KUF5. Positions 6-891.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001227. Ac_transferase_dom. IPR009081. Acyl_carrier_prot-like. IPR014043. Acyl_transferase. IPR016035. Acyl_Trfase/lysoPLipase. IPR000794. Beta-ketoacyl_synthase. IPR002198. DH_sc/Rdtase_SDR. IPR018201. Ketoacyl_synth_AS. IPR014031. Ketoacyl_synth_C. IPR014030. Ketoacyl_synth_N. IPR016036. Malonyl_transacylase_ACP-bd. IPR016040. NAD(P)-bd_dom. IPR006163. Phsphopanteth-bd. IPR020842. PKS/FAS_KR. IPR020801. PKS_acyl_transferase. IPR020841. PKS_Beta-ketoAc_synthase_dom. IPR020806. PKS_PP-bd. IPR015083. Polyketide_synth_docking. IPR006162. PPantetheine_attach_site. IPR016039. Thiolase-like. IPR016038. Thiolase-like_subgr. [Graphical view]
Gene3D	G3DSA:3.40.366.10. Ac_transferase_reg. 2 hits. G3DSA:1.10.1200.10. ACP_like. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:3.40.47.10. Thiolase-like_subgr. 2 hits.
PANTHER	PTHR11712. Ketoacyl_synth. 1 hit.
Pfam	PF00698. Acyl_transf_1. 1 hit. PF00106. adh_short. 1 hit. PF08990. Docking. 1 hit. PF00109. ketoacyl-synt. 1 hit. PF02801. Ketoacyl-synt_C. 1 hit. PF00550. PP-binding. 1 hit. [Graphical view]
SMART	SM00827. PKS_AT. 1 hit. SM00822. PKS_KR. 1 hit. SM00825. PKS_KS. 1 hit. SM00823. PKS_PP. 1 hit. [Graphical view]
SUPFAM	SSF47336. ACP_like. 1 hit. SSF52151. Acyl_Trfase/lysoPlipase. 1 hit. SSF55048. Malonyl_transacylase_ACP-bd. 1 hit. SSF53901. Thiolase-like. 1 hit.
PROSITE	PS50075. ACP_DOMAIN. 1 hit. PS00606. B_KETOACYL_SYNTHASE. 1 hit. PS00012. PHOSPHOPANTETHEINE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8KUF5_ACTPA

Accession

Primary (citable) accession number: Q8KUF5

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)