Reviewed, UniProtKB/Swiss-Prot Q8KTB2 (EFG_RICTY)

Names and origin

Protein names

Recommended name:
    Elongation factor G
      Short name=EF-G

Gene names

Name:	fusA
Ordered Locus Names:	RT0121

Organism

Rickettsia typhi [Complete proteome] [HAMAP]

Taxonomic identifier

785 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This protein promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. HAMAP MF_00054
Subcellular location	Cytoplasm.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Cellular component	Cytoplasm
Ligand	GTP-binding Nucleotide-binding
Molecular function	Elongation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	translational elongation Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 699	699	Elongation factor G HAMAP MF_00054		PRO_0000091205
Regions
	Nucleotide binding	17 – 24	8	GTP By similarity
	Nucleotide binding	81 – 85	5	GTP By similarity
	Nucleotide binding	135 – 138	4	GTP By similarity
Experimental info
	Sequence conflict	263	1	F → L in AAM90925. Ref.1
	Sequence conflict	306	1	T → L in AAM90925. Ref.1
	Sequence conflict	641	1	S → K in AAM90925. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8KTB2-1 [UniParc]. Last modified November 9, 2004. Version 2. Checksum: DAACBEB448B39C37	FASTA	699	77,652
	10 20 30 40 50 60 MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM DWMEQEQERG 70 80 90 100 110 120 ITITSAATTC KWQDKVINII DTPGHVDFTI EVERSLRVLD GAVAVFDGVA GVEPQSETVW 130 140 150 160 170 180 RQADKYNVPR MCFVNKMDRM GADFYKCVDM IKDRLGAKSL ILQLPIGIEE NFKGIINLIK 190 200 210 220 230 240 MKAVIWKDES LGAEYFEEDI PTDMQDKAAE YRARLLDMTV ELDDTIMERY LSGEEITEEE 250 260 270 280 290 300 IKILIRKGTI EAKFYPVLCG SAFKNKGVQP LLDAIVDFLP SPIDIGIVKG IEVSTSEEKD 310 320 330 340 350 360 FPISITEPFS ALAFKIMNDP FVGSLTFIRI YSGKITSGAS VVNTVKNKRE KIGRMLLMHA 370 380 390 400 410 420 NNREDIKEAS AGDIVALAGL KDTSTGDTLS DIDTQVVLER MEFPEPVIEL AVEPKSTADQ 430 440 450 460 470 480 EKMGLALSRL AAEDPSFKVS TDHETGQTVI KGMGELHLEI IIDRMRREFK VEANIGAPQV 490 500 510 520 530 540 AYRETITTAC EIDYTHKKQS GGAGQFARVK IIFEPLKDVI DLKDEDKNKT FVFESKIVGG 550 560 570 580 590 600 AVPKEYIPGV EKGLNNIRET GIVAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKGAFRE 610 620 630 640 650 660 GMQKGNPKLL EPIMKVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV VTAYVPLAEM 670 680 690 FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Proliferation and deterioration of Rickettsia palindromic elements." Amiri H., Alsmark C.M., Andersson S.G.E. Mol. Biol. Evol. 19:1234-1243(2002) [PubMed: 12140235] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Complete genome sequence of Rickettsia typhi and comparison with sequences of other Rickettsiae." McLeod M.P., Qin X., Karpathy S.E., Gioia J., Highlander S.K., Fox G.E., McNeill T.Z., Jiang H., Muzny D., Jacob L.S., Hawes A.C., Sodergren E., Gill R., Hume J., Morgan M., Fan G., Amin A.G., Gibbs R.A. , Hong C., Yu X.-J., Walker D.H., Weinstock G.M. J. Bacteriol. 186:5842-5855(2004) [PubMed: 15317790] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC VR-144 / Wilmington.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF502176 Genomic DNA. Translation: AAM90925.1. AE017197 Genomic DNA. Translation: AAU03607.1.
RefSeq	YP_067089.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2958765.
GenomeReviews	Gene locus RT0121 in contig AE017197_GR.
KEGG	rty:RT0121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8KTB2.
OMA	QEPGKGY
Enzyme and pathway databases
BioCyc	RTYP257363:RT0121-MON.
Family and domain databases
HAMAP	MF_00054. [Tree]
InterPro	IPR009022. Elongation_fac_G/III/V. IPR000795. ProtSyn_GTP_bd. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. IPR005225. Small_GTP_bd. IPR004540. Transl_elong_EFG/EF2. IPR000640. Transl_elong_EFG/EF2_C. IPR005517. Transl_elong_EFG/EF2_IV. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF00679. EFG_C. 1 hit. PF03764. EFG_IV. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SMART	SM00838. EFG_C. 1 hit. SM00889. EFG_IV. 1 hit. [Graphical view]
TIGRFAMs	TIGR00484. EF-G. 1 hit. TIGR00231. small_GTP. 1 hit.
PROSITE	PS00301. EFACTOR_GTP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

EFG_RICTY

Accession

Primary (citable) accession number: Q8KTB2
Secondary accession number(s): Q68XN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 22, 2003
Last sequence update:	November 9, 2004
Last modified:	November 24, 2009
This is version 45 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)