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Q8KTB2

- EFG_RICTY

UniProt

Q8KTB2 - EFG_RICTY

Protein

Elongation factor G

Gene

fusA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 2 (09 Nov 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248GTPUniRule annotation
    Nucleotide bindingi81 – 855GTPUniRule annotation
    Nucleotide bindingi135 – 1384GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciRTYP257363:GJEQ-129-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor GUniRule annotation
    Short name:
    EF-GUniRule annotation
    Gene namesi
    Name:fusAUniRule annotation
    Ordered Locus Names:RT0121
    OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
    Taxonomic identifieri257363 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
    ProteomesiUP000000604: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 699699Elongation factor GPRO_0000091205Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi257363.RT0121.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KTB2.
    SMRiQ8KTB2. Positions 5-694.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 283276tr-type GAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0480.
    HOGENOMiHOG000231585.
    KOiK02355.
    OMAiKQYAETP.
    OrthoDBiEOG6X6RBF.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00054_B. EF_G_EF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SMARTiSM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsiTIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8KTB2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM    50
    DWMEQEQERG ITITSAATTC KWQDKVINII DTPGHVDFTI EVERSLRVLD 100
    GAVAVFDGVA GVEPQSETVW RQADKYNVPR MCFVNKMDRM GADFYKCVDM 150
    IKDRLGAKSL ILQLPIGIEE NFKGIINLIK MKAVIWKDES LGAEYFEEDI 200
    PTDMQDKAAE YRARLLDMTV ELDDTIMERY LSGEEITEEE IKILIRKGTI 250
    EAKFYPVLCG SAFKNKGVQP LLDAIVDFLP SPIDIGIVKG IEVSTSEEKD 300
    FPISITEPFS ALAFKIMNDP FVGSLTFIRI YSGKITSGAS VVNTVKNKRE 350
    KIGRMLLMHA NNREDIKEAS AGDIVALAGL KDTSTGDTLS DIDTQVVLER 400
    MEFPEPVIEL AVEPKSTADQ EKMGLALSRL AAEDPSFKVS TDHETGQTVI 450
    KGMGELHLEI IIDRMRREFK VEANIGAPQV AYRETITTAC EIDYTHKKQS 500
    GGAGQFARVK IIFEPLKDVI DLKDEDKNKT FVFESKIVGG AVPKEYIPGV 550
    EKGLNNIRET GIVAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKGAFRE 600
    GMQKGNPKLL EPIMKVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV 650
    VTAYVPLAEM FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK 699
    Length:699
    Mass (Da):77,652
    Last modified:November 9, 2004 - v2
    Checksum:iDAACBEB448B39C37
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti263 – 2631F → L in AAM90925. (PubMed:12140235)Curated
    Sequence conflicti306 – 3061T → L in AAM90925. (PubMed:12140235)Curated
    Sequence conflicti641 – 6411S → K in AAM90925. (PubMed:12140235)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502176 Genomic DNA. Translation: AAM90925.1.
    AE017197 Genomic DNA. Translation: AAU03607.1.
    RefSeqiYP_067089.1. NC_006142.1.

    Genome annotation databases

    EnsemblBacteriaiAAU03607; AAU03607; RT0121.
    GeneIDi2958765.
    KEGGirty:RT0121.
    PATRICi17909414. VBIRicTyp34752_0128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF502176 Genomic DNA. Translation: AAM90925.1 .
    AE017197 Genomic DNA. Translation: AAU03607.1 .
    RefSeqi YP_067089.1. NC_006142.1.

    3D structure databases

    ProteinModelPortali Q8KTB2.
    SMRi Q8KTB2. Positions 5-694.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 257363.RT0121.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAU03607 ; AAU03607 ; RT0121 .
    GeneIDi 2958765.
    KEGGi rty:RT0121.
    PATRICi 17909414. VBIRicTyp34752_0128.

    Phylogenomic databases

    eggNOGi COG0480.
    HOGENOMi HOG000231585.
    KOi K02355.
    OMAi KQYAETP.
    OrthoDBi EOG6X6RBF.

    Enzyme and pathway databases

    BioCyci RTYP257363:GJEQ-129-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00054_B. EF_G_EF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SMARTi SM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsi TIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Proliferation and deterioration of Rickettsia palindromic elements."
      Amiri H., Alsmark C.M., Andersson S.G.E.
      Mol. Biol. Evol. 19:1234-1243(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC VR-144 / Wilmington.

    Entry informationi

    Entry nameiEFG_RICTY
    AccessioniPrimary (citable) accession number: Q8KTB2
    Secondary accession number(s): Q68XN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 22, 2003
    Last sequence update: November 9, 2004
    Last modified: October 1, 2014
    This is version 81 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Rickettsia typhi
      Rickettsia typhi (strain Wilmington): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3