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Q8KTB2

- EFG_RICTY

UniProt

Q8KTB2 - EFG_RICTY

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Protein
Elongation factor G
Gene
fusA, RT0121
Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248GTP By similarity
Nucleotide bindingi81 – 855GTP By similarity
Nucleotide bindingi135 – 1384GTP By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-HAMAP
  2. GTPase activity Source: InterPro
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRTYP257363:GJEQ-129-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor G
Short name:
EF-G
Gene namesi
Name:fusA
Ordered Locus Names:RT0121
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000000604: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 699699Elongation factor GUniRule annotation
PRO_0000091205Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0121.

Structurei

3D structure databases

ProteinModelPortaliQ8KTB2.
SMRiQ8KTB2. Positions 5-694.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 283276tr-type G
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0480.
HOGENOMiHOG000231585.
KOiK02355.
OMAiKQYAETP.
OrthoDBiEOG6X6RBF.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KTB2-1 [UniParc]FASTAAdd to Basket

« Hide

MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM    50
DWMEQEQERG ITITSAATTC KWQDKVINII DTPGHVDFTI EVERSLRVLD 100
GAVAVFDGVA GVEPQSETVW RQADKYNVPR MCFVNKMDRM GADFYKCVDM 150
IKDRLGAKSL ILQLPIGIEE NFKGIINLIK MKAVIWKDES LGAEYFEEDI 200
PTDMQDKAAE YRARLLDMTV ELDDTIMERY LSGEEITEEE IKILIRKGTI 250
EAKFYPVLCG SAFKNKGVQP LLDAIVDFLP SPIDIGIVKG IEVSTSEEKD 300
FPISITEPFS ALAFKIMNDP FVGSLTFIRI YSGKITSGAS VVNTVKNKRE 350
KIGRMLLMHA NNREDIKEAS AGDIVALAGL KDTSTGDTLS DIDTQVVLER 400
MEFPEPVIEL AVEPKSTADQ EKMGLALSRL AAEDPSFKVS TDHETGQTVI 450
KGMGELHLEI IIDRMRREFK VEANIGAPQV AYRETITTAC EIDYTHKKQS 500
GGAGQFARVK IIFEPLKDVI DLKDEDKNKT FVFESKIVGG AVPKEYIPGV 550
EKGLNNIRET GIVAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKGAFRE 600
GMQKGNPKLL EPIMKVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV 650
VTAYVPLAEM FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK 699
Length:699
Mass (Da):77,652
Last modified:November 9, 2004 - v2
Checksum:iDAACBEB448B39C37
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti263 – 2631F → L in AAM90925. 1 Publication
Sequence conflicti306 – 3061T → L in AAM90925. 1 Publication
Sequence conflicti641 – 6411S → K in AAM90925. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502176 Genomic DNA. Translation: AAM90925.1.
AE017197 Genomic DNA. Translation: AAU03607.1.
RefSeqiYP_067089.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03607; AAU03607; RT0121.
GeneIDi2958765.
KEGGirty:RT0121.
PATRICi17909414. VBIRicTyp34752_0128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF502176 Genomic DNA. Translation: AAM90925.1 .
AE017197 Genomic DNA. Translation: AAU03607.1 .
RefSeqi YP_067089.1. NC_006142.1.

3D structure databases

ProteinModelPortali Q8KTB2.
SMRi Q8KTB2. Positions 5-694.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 257363.RT0121.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAU03607 ; AAU03607 ; RT0121 .
GeneIDi 2958765.
KEGGi rty:RT0121.
PATRICi 17909414. VBIRicTyp34752_0128.

Phylogenomic databases

eggNOGi COG0480.
HOGENOMi HOG000231585.
KOi K02355.
OMAi KQYAETP.
OrthoDBi EOG6X6RBF.

Enzyme and pathway databases

BioCyci RTYP257363:GJEQ-129-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPi MF_00054_B. EF_G_EF_2_B.
InterProi IPR000795. EF_GTP-bd_dom.
IPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
IPR004161. Transl_elong_EFTu/EF1A_2.
[Graphical view ]
Pfami PF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view ]
PRINTSi PR00315. ELONGATNFCT.
SMARTi SM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view ]
SUPFAMi SSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsi TIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEi PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Proliferation and deterioration of Rickettsia palindromic elements."
    Amiri H., Alsmark C.M., Andersson S.G.E.
    Mol. Biol. Evol. 19:1234-1243(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC VR-144 / Wilmington.

Entry informationi

Entry nameiEFG_RICTY
AccessioniPrimary (citable) accession number: Q8KTB2
Secondary accession number(s): Q68XN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 9, 2004
Last modified: September 3, 2014
This is version 80 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi