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Protein

Elongation factor G

Gene

fusA

Organism
Rickettsia typhi (strain ATCC VR-144 / Wilmington)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24GTPUniRule annotation8
Nucleotide bindingi81 – 85GTPUniRule annotation5
Nucleotide bindingi135 – 138GTPUniRule annotation4

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Elongation factor

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor GUniRule annotation
Short name:
EF-GUniRule annotation
Gene namesi
Name:fusAUniRule annotation
Ordered Locus Names:RT0121
OrganismiRickettsia typhi (strain ATCC VR-144 / Wilmington)
Taxonomic identifieri257363 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
Proteomesi
  • UP000000604 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000912051 – 699Elongation factor GAdd BLAST699

Interactioni

Protein-protein interaction databases

STRINGi257363.RT0121.

Structurei

3D structure databases

ProteinModelPortaliQ8KTB2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 283tr-type GAdd BLAST276

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231585.
KOiK02355.
OMAiKLGVAIQ.
OrthoDBiPOG091H02CO.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KTB2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKINKLEHI RNIGICAHID AGKTTTTERI LYYTGKSHKI GEVHEGGATM
60 70 80 90 100
DWMEQEQERG ITITSAATTC KWQDKVINII DTPGHVDFTI EVERSLRVLD
110 120 130 140 150
GAVAVFDGVA GVEPQSETVW RQADKYNVPR MCFVNKMDRM GADFYKCVDM
160 170 180 190 200
IKDRLGAKSL ILQLPIGIEE NFKGIINLIK MKAVIWKDES LGAEYFEEDI
210 220 230 240 250
PTDMQDKAAE YRARLLDMTV ELDDTIMERY LSGEEITEEE IKILIRKGTI
260 270 280 290 300
EAKFYPVLCG SAFKNKGVQP LLDAIVDFLP SPIDIGIVKG IEVSTSEEKD
310 320 330 340 350
FPISITEPFS ALAFKIMNDP FVGSLTFIRI YSGKITSGAS VVNTVKNKRE
360 370 380 390 400
KIGRMLLMHA NNREDIKEAS AGDIVALAGL KDTSTGDTLS DIDTQVVLER
410 420 430 440 450
MEFPEPVIEL AVEPKSTADQ EKMGLALSRL AAEDPSFKVS TDHETGQTVI
460 470 480 490 500
KGMGELHLEI IIDRMRREFK VEANIGAPQV AYRETITTAC EIDYTHKKQS
510 520 530 540 550
GGAGQFARVK IIFEPLKDVI DLKDEDKNKT FVFESKIVGG AVPKEYIPGV
560 570 580 590 600
EKGLNNIRET GIVAGYPMID FKATLVDGAF HDVDSSVLAF EIAAKGAFRE
610 620 630 640 650
GMQKGNPKLL EPIMKVEVIT PDEYMGDIIG DLNSRRGQIQ SMDPRGNAQV
660 670 680 690
VTAYVPLAEM FGYVNTLRSL SQGRAQFSMI FSHYDQVPSQ VADIIKAKK
Length:699
Mass (Da):77,652
Last modified:November 9, 2004 - v2
Checksum:iDAACBEB448B39C37
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti263F → L in AAM90925 (PubMed:12140235).Curated1
Sequence conflicti306T → L in AAM90925 (PubMed:12140235).Curated1
Sequence conflicti641S → K in AAM90925 (PubMed:12140235).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502176 Genomic DNA. Translation: AAM90925.1.
AE017197 Genomic DNA. Translation: AAU03607.1.
RefSeqiWP_011190594.1. NC_006142.1.

Genome annotation databases

EnsemblBacteriaiAAU03607; AAU03607; RT0121.
KEGGirty:RT0121.
PATRICi17909414. VBIRicTyp34752_0128.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF502176 Genomic DNA. Translation: AAM90925.1.
AE017197 Genomic DNA. Translation: AAU03607.1.
RefSeqiWP_011190594.1. NC_006142.1.

3D structure databases

ProteinModelPortaliQ8KTB2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi257363.RT0121.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAU03607; AAU03607; RT0121.
KEGGirty:RT0121.
PATRICi17909414. VBIRicTyp34752_0128.

Phylogenomic databases

eggNOGiENOG4105CEJ. Bacteria.
COG0480. LUCA.
HOGENOMiHOG000231585.
KOiK02355.
OMAiKLGVAIQ.
OrthoDBiPOG091H02CO.

Family and domain databases

CDDicd01434. EFG_mtEFG1_IV. 1 hit.
Gene3Di3.30.230.10. 1 hit.
3.30.70.240. 1 hit.
3.40.50.300. 1 hit.
HAMAPiMF_00054_B. EF_G_EF_2_B. 1 hit.
InterProiIPR009022. EFG_III-V.
IPR000640. EFG_V.
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR005225. Small_GTP-bd_dom.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR004540. Transl_elong_EFG/EF2.
IPR005517. Transl_elong_EFG/EF2_IV.
[Graphical view]
PfamiPF00679. EFG_C. 1 hit.
PF14492. EFG_II. 1 hit.
PF03764. EFG_IV. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SMARTiSM00838. EFG_C. 1 hit.
SM00889. EFG_IV. 1 hit.
[Graphical view]
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF54211. SSF54211. 1 hit.
SSF54980. SSF54980. 2 hits.
TIGRFAMsiTIGR00484. EF-G. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiEFG_RICTY
AccessioniPrimary (citable) accession number: Q8KTB2
Secondary accession number(s): Q68XN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: November 9, 2004
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Rickettsia typhi
    Rickettsia typhi (strain Wilmington): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.