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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Synechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

  1. arginine-tRNA ligase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1577-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:Synpcc7942_1577
ORF Names:sed0009
OrganismiSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2)
Taxonomic identifieri1140 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus
ProteomesiUP000002717: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 584584Arginine--tRNA ligasePRO_0000151625Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1577.

Structurei

3D structure databases

ProteinModelPortaliQ8KPU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 13611"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247212.
KOiK01887.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8KPU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPLAQLRD RFQAALAASF GPEWAATDPL LVPATNPKFG DYQSNVAMSL
60 70 80 90 100
AKQLGQPPRA IAETLVQNLN LADLCEPPAI AGPGFINFTL QPSYLVAQLQ
110 120 130 140 150
QLQTDERLGI QPVSPPQRVI VDFSSPNIAK EMHVGHLRST IIGDSIARVL
160 170 180 190 200
EFQGHEVLRL NHVGDWGTQF GMLIAFLQEQ YPQALSQPDA LDISDLVAFY
210 220 230 240 250
KQAKARFDED PSFQETARQR VVDLQSGEAT ARQAWQLLCD QSRREFQKIY
260 270 280 290 300
DRLDIQLEER GESFYNPYLP AIVEDLRRLG LLVEDQGAQC VFLEGFQNKE
310 320 330 340 350
GQPLPLIVQK SDGGYNYATT DLAALRYRLG QDQAQRIIYV TDSGQANHFA
360 370 380 390 400
QVFQVAQRAG WLPAAAQIEH VPFGLVQGED GKKLKTRAGD TVRLRDLLDE
410 420 430 440 450
AVDRARTDLT TRIAAEERSE TPEFIEAVAQ AVGLGAVKYA DLSQNRNSNY
460 470 480 490 500
IFSFDKMLAL QGNTAPYLLY AYVRIQGIAR KGGIDFAQLD PVAAVLTEPT
510 520 530 540 550
ERSLAKQVLQ LGEVLDEVAR DLLPNRLCSY LFELSQTFNQ FYDRCPILNA
560 570 580
EEPQRTSRLL LCDLTARTLK LGLSLLGISV LERM
Length:584
Mass (Da):65,052
Last modified:April 18, 2006 - v2
Checksum:iA84B3956A6DF5BBA
GO

Sequence cautioni

The sequence ABB57607.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti516 – 5161D → N in AAM82666 (Ref. 1) Curated
Sequence conflicti561 – 5611L → V in AAM82666 (Ref. 1) Curated
Sequence conflicti566 – 5661A → G in AAM82666 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY120852 Genomic DNA. Translation: AAM82666.1.
CP000100 Genomic DNA. Translation: ABB57607.1. Different initiation.
RefSeqiYP_400594.1. NC_007604.1.

Genome annotation databases

EnsemblBacteriaiABB57607; ABB57607; Synpcc7942_1577.
GeneIDi3775001.
KEGGisyf:Synpcc7942_1577.
PATRICi23788545. VBISynElo51371_1796.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY120852 Genomic DNA. Translation: AAM82666.1.
CP000100 Genomic DNA. Translation: ABB57607.1. Different initiation.
RefSeqiYP_400594.1. NC_007604.1.

3D structure databases

ProteinModelPortaliQ8KPU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi1140.Synpcc7942_1577.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABB57607; ABB57607; Synpcc7942_1577.
GeneIDi3775001.
KEGGisyf:Synpcc7942_1577.
PATRICi23788545. VBISynElo51371_1796.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247212.
KOiK01887.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciSYNEL:SYNPCC7942_1577-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Synechococcus elongatus PCC7942 cosmid 6C3."
    Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
    US DOE Joint Genome Institute
    Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 7942.

Entry informationi

Entry nameiSYR_SYNE7
AccessioniPrimary (citable) accession number: Q8KPU9
Secondary accession number(s): Q31MW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 18, 2006
Last modified: January 7, 2015
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.