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Q8KPU9 (SYR_SYNE7) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:Synpcc7942_1577
ORF Names:sed0009
OrganismSynechococcus elongatus (strain PCC 7942) (Anacystis nidulans R2) [Complete proteome] [HAMAP]
Taxonomic identifier1140 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechococcus

Protein attributes

Sequence length584 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence ABB57607.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 584584Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151625

Regions

Motif126 – 13611"HIGH" region HAMAP-Rule MF_00123

Experimental info

Sequence conflict5161D → N in AAM82666. Ref.1
Sequence conflict5611L → V in AAM82666. Ref.1
Sequence conflict5661A → G in AAM82666. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8KPU9 [UniParc].

Last modified April 18, 2006. Version 2.
Checksum: A84B3956A6DF5BBA

FASTA58465,052
        10         20         30         40         50         60 
MAAPLAQLRD RFQAALAASF GPEWAATDPL LVPATNPKFG DYQSNVAMSL AKQLGQPPRA 

        70         80         90        100        110        120 
IAETLVQNLN LADLCEPPAI AGPGFINFTL QPSYLVAQLQ QLQTDERLGI QPVSPPQRVI 

       130        140        150        160        170        180 
VDFSSPNIAK EMHVGHLRST IIGDSIARVL EFQGHEVLRL NHVGDWGTQF GMLIAFLQEQ 

       190        200        210        220        230        240 
YPQALSQPDA LDISDLVAFY KQAKARFDED PSFQETARQR VVDLQSGEAT ARQAWQLLCD 

       250        260        270        280        290        300 
QSRREFQKIY DRLDIQLEER GESFYNPYLP AIVEDLRRLG LLVEDQGAQC VFLEGFQNKE 

       310        320        330        340        350        360 
GQPLPLIVQK SDGGYNYATT DLAALRYRLG QDQAQRIIYV TDSGQANHFA QVFQVAQRAG 

       370        380        390        400        410        420 
WLPAAAQIEH VPFGLVQGED GKKLKTRAGD TVRLRDLLDE AVDRARTDLT TRIAAEERSE 

       430        440        450        460        470        480 
TPEFIEAVAQ AVGLGAVKYA DLSQNRNSNY IFSFDKMLAL QGNTAPYLLY AYVRIQGIAR 

       490        500        510        520        530        540 
KGGIDFAQLD PVAAVLTEPT ERSLAKQVLQ LGEVLDEVAR DLLPNRLCSY LFELSQTFNQ 

       550        560        570        580 
FYDRCPILNA EEPQRTSRLL LCDLTARTLK LGLSLLGISV LERM 

« Hide

References

« Hide 'large scale' references
[1]"Synechococcus elongatus PCC7942 cosmid 6C3."
Holtman C.K., Sandoval P., Chen Y., Socias T., Mohler B.J., Gonzalez A., Salinas I., McMurtry S., Golden S.S., Youderian P.
Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942."
US DOE Joint Genome Institute
Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T., Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M., Kyrpides N., Lykidis A., Richardson P.
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 7942.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY120852 Genomic DNA. Translation: AAM82666.1.
CP000100 Genomic DNA. Translation: ABB57607.1. Different initiation.
RefSeqYP_400594.1. NC_007604.1.

3D structure databases

ProteinModelPortalQ8KPU9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1140.Synpcc7942_1577.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABB57607; ABB57607; Synpcc7942_1577.
GeneID3775001.
KEGGsyf:Synpcc7942_1577.
PATRIC23788545. VBISynElo51371_1796.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0018.
HOGENOMHOG000247212.
KOK01887.
OrthoDBEOG6JB13C.

Enzyme and pathway databases

BioCycSYNEL:SYNPCC7942_1577-MONOMER.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_SYNE7
AccessionPrimary (citable) accession number: Q8KPU9
Secondary accession number(s): Q31MW2
Entry history
Integrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: April 18, 2006
Last modified: May 14, 2014
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries