ID   MCH_METDI               Reviewed;         323 AA.
AC   Q8KMJ5;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 33.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; Synonyms=mchA;
OS   Methylobacterium dichloromethanicum.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Methylobacteriaceae; Methylobacterium.
OX   NCBI_TaxID=119024;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=DM4;
RX   MEDLINE=22051057; PubMed=12055310;
RA   Kayser M.F., Ucurum Z., Vuilleumier S.;
RT   "Dichloromethane metabolism and C1 utilization genes in
RT   Methylobacterium strains.";
RL   Microbiology 148:1915-1922(2002).
CC   -!- FUNCTION: Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-
CC       formyl-H(4)MPT (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
CC       + H(2)O = 5-formyl-5,6,7,8-tetrahydromethanopterin.
CC   -!- PATHWAY: One-carbon metabolism; formaldehyde degradation; formate
CC       from formaldehyde (H(4)MPT route): step 3/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the MCH family.
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DR   EMBL; AJ421477; CAD13315.1; -; Genomic_DNA.
DR   HSSP; P94954; 1QLM.
DR   BRENDA; 3.5.4.27; 288916.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrol...; IEA:HAMAP.
DR   GO; GO:0006730; P:one-carbon compound metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00486; -; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   ProDom; PD011637; Cyclohydrolase; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; One-carbon metabolism.
FT   CHAIN         1    323       Methenyltetrahydromethanopterin
FT                                cyclohydrolase.
FT                                /FTId=PRO_0000140894.
SQ   SEQUENCE   323 AA;  33268 MW;  900FF2379E84F531 CRC64;
     MSSNTSAPSL NALAGPLVES LVADAAKLRL IVAQENGART VDAGANARGS IEAGRRIAEI
     CLGGLGTVTI APIGPVASWP YTVVVHSADP VLACLGSQYA GWSLADEDGD SGFFALGSGP
     GRAVAVVEEL YKELGYRDNA TTTALVLESG SAPPASVVNK VAAATGLAPE NVTFIYAPTQ
     SLAGSTQVVA RVLEVALHKA HTVGFDLHKI LDGIGSAPLS PPHPDFIQAM GRTNDAIIYG
     GRVQLFVDAD DADAKQLAEQ IPSTTSADHG APFAEIFSRV NGDFYKIDGA LFSPAEAIVT
     SVKTGKSFRG GRLEPQLVDA SFV
//