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Protein

(R)-2-haloacid dehalogenase

Gene

dehI

Organism
Rhizobium sp. (strain NHG3)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the hydrolytic dehalogenation of small (R)-2-haloalkanoic acids to yield the corresponding (S)-2-hydroxyalkanoic acids. Acts on acids of short chain lengths, C2 to C4, with inversion of configuration at C-2.

Catalytic activityi

(R)-2-haloacid + H2O = (S)-2-hydroxyacid + halide.

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BRENDAi3.8.1.9 206

Names & Taxonomyi

Protein namesi
Recommended name:
(R)-2-haloacid dehalogenase (EC:3.8.1.9)
Alternative name(s):
D-2-haloacid dehalogenase
D-DEX
D-specific mono chloro propionoic acid dehalogenase
DehIII
Gene namesi
Name:dehI
Synonyms:dehD
OrganismiRhizobium sp. (strain NHG3)
Taxonomic identifieri196607 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000791701 – 257(R)-2-haloacid dehalogenaseAdd BLAST257

Structurei

3D structure databases

ProteinModelPortaliQ8KLS9
SMRiQ8KLS9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR019714 2-haloacid_dehalogenase_DehI
PfamiView protein in Pfam
PF10778 DehI, 2 hits

Sequencei

Sequence statusi: Complete.

Q8KLS9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIDLPRHPPS MLPVIRTVPE HAATGELKRR YDAVKSAFDV PWMGVVAMAH
60 70 80 90 100
TQYPRFFDAL WEGFEPIAGT RAFQDACRAM RAATEAGVER SLGISPLAHR
110 120 130 140 150
LQDLGYDPRE IGEIRTIIEV FSHGNYPYIL LATVSRYLLS GGDLSGEPQV
160 170 180 190 200
FETSPRSPHI FHQPILMEPH HADEHTRGIF ADIQATLALP ILNTDYRALA
210 220 230 240 250
RWPSYFHLAW AELRPLIRTP SHAALSQQLH EQAIAVLRTL PNPARLKGDM

VTRGCGR
Length:257
Mass (Da):28,838
Last modified:October 1, 2002 - v1
Checksum:i407B32108A8D08F0
GO

Sequence cautioni

The sequence CAA63793 differs from that shown. Several sequencing errors.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X93597 Genomic DNA Translation: CAA63793.1 Sequence problems.
AJ488572 Genomic DNA Translation: CAD56483.1
PIRiS62363

Entry informationi

Entry nameiHADD_RHISH
AccessioniPrimary (citable) accession number: Q8KLS9
Secondary accession number(s): Q53186
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2002
Last modified: February 28, 2018
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing
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Main funding by: National Institutes of Health