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Q8KLP4 (Q8KLP4_STEMA) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain. RuleBase RU000710

Contains HTH tetR-type DNA-binding domain. SAAS SAAS001647

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region154 – 1552Sulfate binding PDB 2W53 PDB 3P9T

Sites

Binding site2031Sulfate PDB 2W53 PDB 3P9T

Sequences

Sequence LengthMass (Da)Tools
Q8KLP4 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: AE640E4085815BE8

FASTA21924,623
        10         20         30         40         50         60 
MARKTKEDTQ ATREGILDAA EACFHEHGVA RTTLEMIGAR AGYTRGAVYW HFKNKSEVLA 

        70         80         90        100        110        120 
AIVERVHLPF MQELERTSTD QRDTPVHDLR AVMIHSFIEL SEDERLRKTM EIMLRSDASA 

       130        140        150        160        170        180 
NTRVLTEMQQ AGFRDALDRM ERALRRARDL GQLREGADPK IAARMQHATV LGVLHGAMVE 

       190        200        210 
PELMDLKRDG MLALDMTLAA YVKDGVFVPG TVPEPLPEA 

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References

[1]"Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF."
Sanchez P., Alonso A., Martinez J.L.
Antimicrob. Agents Chemother. 46:3386-3393(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: D457R EMBL CAC87048.1.
[2]"Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF."
Hernandez A., Mate M.J., Sanchez-Diaz P.C., Romero A., Rojo F., Martinez J.L.
J. Biol. Chem. 284:14428-14438(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) IN COMPLEX WITH SULFATE.
[3]"The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia."
Hernandez A., Ruiz F.M., Romero A., Martinez J.L.
PLoS Pathog. 7:e1002103-e1002103(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS) IN COMPLEX WITH SULFATE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ316010 Genomic DNA. Translation: CAC87048.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2W53X-ray2.00A/B1-219[»]
3P9TX-ray2.02A/B1-219[»]
ProteinModelPortalQ8KLP4.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.357.10. 1 hit.
InterProIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]
PfamPF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSPR00455. HTHTETR.
SUPFAMSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
PROSITEPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ8KLP4.

Entry information

Entry nameQ8KLP4_STEMA
AccessionPrimary (citable) accession number: Q8KLP4
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)