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Q8KLP4

- Q8KLP4_STEMA

UniProt

Q8KLP4 - Q8KLP4_STEMA

Protein
Submitted name:

Repressor

Gene

smeT

Organism
Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei203 – 2031SulfateImported

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    RepressorImported
    Gene namesi
    Name:smeTImported
    OrganismiStenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia)Imported
    Taxonomic identifieri40324 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeStenotrophomonasStenotrophomonas maltophilia group

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2W53X-ray2.00A/B1-219[»]
    3P9TX-ray2.02A/B1-219[»]
    ProteinModelPortaliQ8KLP4.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8KLP4.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni154 – 1552Sulfate bindingImported

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation
    Contains HTH tetR-type DNA-binding domain.SAAS annotation

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    InterProiIPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR013572. Tscrpt_reg_MAATS_C.
    [Graphical view]
    PfamiPF08361. TetR_C_2. 1 hit.
    PF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEiPS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8KLP4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARKTKEDTQ ATREGILDAA EACFHEHGVA RTTLEMIGAR AGYTRGAVYW    50
    HFKNKSEVLA AIVERVHLPF MQELERTSTD QRDTPVHDLR AVMIHSFIEL 100
    SEDERLRKTM EIMLRSDASA NTRVLTEMQQ AGFRDALDRM ERALRRARDL 150
    GQLREGADPK IAARMQHATV LGVLHGAMVE PELMDLKRDG MLALDMTLAA 200
    YVKDGVFVPG TVPEPLPEA 219
    Length:219
    Mass (Da):24,623
    Last modified:October 1, 2002 - v1
    Checksum:iAE640E4085815BE8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316010 Genomic DNA. Translation: CAC87048.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ316010 Genomic DNA. Translation: CAC87048.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2W53 X-ray 2.00 A/B 1-219 [» ]
    3P9T X-ray 2.02 A/B 1-219 [» ]
    ProteinModelPortali Q8KLP4.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei Q8KLP4.

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    InterProi IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR013572. Tscrpt_reg_MAATS_C.
    [Graphical view ]
    Pfami PF08361. TetR_C_2. 1 hit.
    PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    PROSITEi PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF."
      Sanchez P., Alonso A., Martinez J.L.
      Antimicrob. Agents Chemother. 46:3386-3393(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: D457RImported.
    2. "Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF."
      Hernandez A., Mate M.J., Sanchez-Diaz P.C., Romero A., Rojo F., Martinez J.L.
      J. Biol. Chem. 284:14428-14438(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
    3. "The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia."
      Hernandez A., Ruiz F.M., Romero A., Martinez J.L.
      PLoS Pathog. 7:e1002103-e1002103(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS).

    Entry informationi

    Entry nameiQ8KLP4_STEMA
    AccessioniPrimary (citable) accession number: Q8KLP4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3