Q8KLP4 (Q8KLP4_STEMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Repressor EMBL CAC87048.1

Gene names

Name:

smeT EMBL CAC87048.1

Organism

Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia) EMBL CAC87048.1

Taxonomic identifier

40324 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Stenotrophomonas › Stenotrophomonas maltophilia group

Protein attributes

Sequence length	219 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Contains 1 HTH tetR-type DNA-binding domain. RuleBase RU000710 SAAS SAAS001647

Ontologies

Keywords
Biological process	Transcription Transcription regulation RuleBase RU000710 SAAS SAAS001647
Ligand	DNA-binding RuleBase RU000710 SAAS SAAS001647
Technical term	3D-structure PDB 2W53 PDB 3P9T
Gene Ontology (GO)
Biological_process	regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KLP4 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: AE640E4085815BE8	FASTA	219	24,623
	10 20 30 40 50 60 MARKTKEDTQ ATREGILDAA EACFHEHGVA RTTLEMIGAR AGYTRGAVYW HFKNKSEVLA 70 80 90 100 110 120 AIVERVHLPF MQELERTSTD QRDTPVHDLR AVMIHSFIEL SEDERLRKTM EIMLRSDASA 130 140 150 160 170 180 NTRVLTEMQQ AGFRDALDRM ERALRRARDL GQLREGADPK IAARMQHATV LGVLHGAMVE 190 200 210 PELMDLKRDG MLALDMTLAA YVKDGVFVPG TVPEPLPEA

References

[1]	"Cloning and characterization of SmeT, a repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF." Sanchez P., Alonso A., Martinez J.L. Antimicrob. Agents Chemother. 46:3386-3393(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: D457R EMBL CAC87048.1.
[2]	"Structural and functional analysis of SmeT, the repressor of the Stenotrophomonas maltophilia multidrug efflux pump SmeDEF." Hernandez A., Mate M.J., Sanchez-Diaz P.C., Romero A., Rojo F., Martinez J.L. J. Biol. Chem. 284:14428-14438(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS).
[3]	"The binding of triclosan to SmeT, the repressor of the multidrug efflux pump SmeDEF, induces antibiotic resistance in Stenotrophomonas maltophilia." Hernandez A., Ruiz F.M., Romero A., Martinez J.L. PLoS Pathog. 7:e1002103-e1002103(2011) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.02 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AJ316010 Genomic DNA. Translation: CAC87048.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2W53	X-ray	2.00	A/B	1-219	[»]
3P9T	X-ray	2.02	A/B	1-219	[»]

ProteinModelPortal

Q8KLP4.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.357.10. 1 hit.

InterPro

IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR013572. Tscrpt_reg_MAATS_C.
[Graphical view]

Pfam

PF08361. TetR_C_2. 1 hit.
PF00440. TetR_N. 1 hit.
[Graphical view]

PRINTS

PR00455. HTHTETR.

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF48498. TetR_like_C. 1 hit.

PROSITE

PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q8KLP4.

Entry information

Entry name

Q8KLP4_STEMA

Accession

Primary (citable) accession number: Q8KLP4

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)