Q8KKS1 (APT2_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine phosphoribosyltransferase 2
Short name=APRT 2
EC=2.4.2.7

Gene names

Name:	apt2
Ordered Locus Names:	RHE_PD00341

Encoded on

Plasmid sym p42d

Organism

Rhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]

Taxonomic identifier

347834 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Rhizobiaceae › Rhizobium/Agrobacterium group › Rhizobium

Protein attributes

Sequence length	184 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP MF_00004
Catalytic activity	AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00004
Pathway	Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP MF_00004
Subunit structure	Homodimer By similarity. HAMAP MF_00004
Subcellular location	Cytoplasm By similarity HAMAP MF_00004.
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
Biological process	Purine salvage
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	adenine salvage Inferred from electronic annotation. Source: InterPro purine ribonucleoside salvage Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	adenine phosphoribosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 184	184	Adenine phosphoribosyltransferase 2 HAMAP MF_00004		PRO_0000334716

Sequences

	Sequence		Length	Mass (Da)
	Q8KKS1 [UniParc]. Last modified April 4, 2006. Version 2. Checksum: 9B715686CDB75F91	FASTA	184	19,027
	10 20 30 40 50 60 MIVAVPNSGA SRINQSGVEA LREFPNFPIG GILFKDIAPM LAGRGALGEV VSTVASQVSG 70 80 90 100 110 120 TEIDAILAVD ARGFILGASL ADRLGCGFIM VRKPGKLPGD VLSFEYSCEY CSGTLEVTAG 130 140 150 160 170 180 LIGDGLRCLI ADDLLATGGT ARATGNFVKS QGGEIAGYAF ILEIEVLKGR RQLDDAPVIS AMTC

References

[1]	"The mosaic structure of the symbiotic plasmid of Rhizobium etli CFN42 and its relation to other symbiotic genome compartments." Gonzalez V., Bustos P., Ramirez-Romero M.A., Medrano-Soto A., Salgado H., Hernandez-Gonzalez I., Hernandez-Celis J.C., Quintero V., Moreno-Hagelsieb G., Girard L., Rodriguez O., Flores M., Cevallos M.A., Collado-Vides J., Romero D., Davila G. Genome Biol. 4:R36.1-R36.13(2003) [PubMed: 12801410] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFN 42 / ATCC 51251.
[2]	"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons." Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G. Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed: 16505379] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CFN 42 / ATCC 51251.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U80928 Genomic DNA. Translation: AAM55053.2.
RefSeq	NP_660052.2. NC_004041.2.
3D structure databases
HSSP	HSSP built from PDB template 1ZN8 based on UniProtKB P07741.
ProteinModelPortal	Q8KKS1.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8KKS1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1005231.
GenomeReviews	Gene locus RHE_PD00341 in contig U80928_GR.
KEGG	ret:RHE_PD00341.
PATRIC	23081243. VBIRhiEtl108884_0314.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0503.
HOGENOM	HBG703830.
OMA	APVISAM.
PhylomeDB	Q8KKS1.
ProtClustDB	PRK02304.
Family and domain databases
HAMAP	MF_00004. Aden_phosphoribosyltr. [Tree]
InterPro	IPR005764. Ade_phspho_trans. IPR000836. PRibTrfase. [Graphical view]
KO	K00759.
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

APT2_RHIEC

Accession

Primary (citable) accession number: Q8KKS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program