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Q8KKS1 (APT2_RHIEC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Adenine phosphoribosyltransferase 2

Short name=APRT 2
EC=2.4.2.7
Gene names
Name:apt2
Ordered Locus Names:RHE_PD00341
Encoded onPlasmid sym p42d
OrganismRhizobium etli (strain CFN 42 / ATCC 51251) [Complete proteome] [HAMAP]
Taxonomic identifier347834 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium

Protein attributes

Sequence length184 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis By similarity. HAMAP-Rule MF_00004

Catalytic activity

AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00004

Pathway

Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1. HAMAP-Rule MF_00004

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00004

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00004.

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family.

Ontologies

Keywords
   Biological processPurine salvage
   Cellular componentCytoplasm
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Plasmid
Gene Ontology (GO)
   Biological_processAMP salvage

Inferred from electronic annotation. Source: UniProtKB-UniPathway

adenine salvage

Inferred from electronic annotation. Source: InterPro

purine ribonucleoside salvage

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionadenine phosphoribosyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 184184Adenine phosphoribosyltransferase 2 HAMAP-Rule MF_00004
PRO_0000334716

Sequences

Sequence LengthMass (Da)Tools
Q8KKS1 [UniParc].

Last modified April 4, 2006. Version 2.
Checksum: 9B715686CDB75F91

FASTA18419,027
        10         20         30         40         50         60 
MIVAVPNSGA SRINQSGVEA LREFPNFPIG GILFKDIAPM LAGRGALGEV VSTVASQVSG 

        70         80         90        100        110        120 
TEIDAILAVD ARGFILGASL ADRLGCGFIM VRKPGKLPGD VLSFEYSCEY CSGTLEVTAG 

       130        140        150        160        170        180 
LIGDGLRCLI ADDLLATGGT ARATGNFVKS QGGEIAGYAF ILEIEVLKGR RQLDDAPVIS 


AMTC 

« Hide

References

[1]"The mosaic structure of the symbiotic plasmid of Rhizobium etli CFN42 and its relation to other symbiotic genome compartments."
Gonzalez V., Bustos P., Ramirez-Romero M.A., Medrano-Soto A., Salgado H., Hernandez-Gonzalez I., Hernandez-Celis J.C., Quintero V., Moreno-Hagelsieb G., Girard L., Rodriguez O., Flores M., Cevallos M.A., Collado-Vides J., Romero D., Davila G.
Genome Biol. 4:R36.1-R36.13(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.
[2]"The partitioned Rhizobium etli genome: genetic and metabolic redundancy in seven interacting replicons."
Gonzalez V., Santamaria R.I., Bustos P., Hernandez-Gonzalez I., Medrano-Soto A., Moreno-Hagelsieb G., Janga S.C., Ramirez M.A., Jimenez-Jacinto V., Collado-Vides J., Davila G.
Proc. Natl. Acad. Sci. U.S.A. 103:3834-3839(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: CFN 42 / ATCC 51251.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U80928 Genomic DNA. Translation: AAM55053.2.
RefSeqNP_660052.2. NC_004041.2.

3D structure databases

ProteinModelPortalQ8KKS1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING347834.RHE_PD00341.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM55053; AAM55053; RHE_PD00341.
GeneID1005231.
KEGGret:RHE_PD00341.
PATRIC23081243. VBIRhiEtl108884_0314.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0503.
HOGENOMHOG000036776.
KOK00759.
OMAAPVISAM.
OrthoDBEOG6T4S55.
ProtClustDBPRK02304.

Enzyme and pathway databases

BioCycRETL347834:GJJ0-5567-MONOMER.
UniPathwayUPA00588; UER00646.

Family and domain databases

HAMAPMF_00004. Aden_phosphoribosyltr.
InterProIPR005764. Ade_phspho_trans.
IPR000836. PRibTrfase_dom.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAPT2_RHIEC
AccessionPrimary (citable) accession number: Q8KKS1
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: April 4, 2006
Last modified: February 19, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways