Q8KGG6 (DNAA_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein DnaA

Gene names

Name:	dnaA
Ordered Locus Names:	CT0002

Organism

Chlorobium tepidum

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	493 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity. HAMAP MF_00377
Subcellular location	Cytoplasm By similarity HAMAP MF_00377.
Sequence similarities	Belongs to the DnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	DNA-dependent DNA replication initiation Inferred from electronic annotation. Source: InterPro regulation of DNA replication Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW DNA replication origin binding Inferred from electronic annotation. Source: InterPro nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 493	493	Chromosomal replication initiator protein DnaA HAMAP MF_00377		PRO_0000114161
Regions
	Nucleotide binding	195 – 202	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8KGG6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F45E27E63876296A	FASTA	493	55,427
	10 20 30 40 50 60 MSDTIQQEAP DNLQVTPTHG RSFAEKVWSA CLGLIQENIN TLAFKTWFLP IRPLSFSGSE 70 80 90 100 110 120 LTIEVPSQFF YEWIEENYSV HVKQALRQVI GPEAKLMYSI VIDKSQGQPV TIELPHQIDA 130 140 150 160 170 180 APAERSVRPE APGQKASAER ERLEIARPRF ESNLNPKYTF STLVRGDCNS LAFAASKSIA 190 200 210 220 230 240 QNPGQNAFNP LVIYGGVGLG KTHMMQAIGN SVLENRITDA VLYVSSEKFA IDFVNAIQNG 250 260 270 280 290 300 NIQEFSAFYR NIDVLIIDDI QFFAGKEKTQ EEIFHIFNTL HQSNKQIILS ADRPIKEIKG 310 320 330 340 350 360 IEDRLISRFN WGLSTDIQAP DYETRKAIIQ SKLKQSGVSL DPVVIEFIAT NVTSNVRELE 370 380 390 400 410 420 GCIVKLLAAH SLDNQEIDLQ FAKSTLKDII RYNTKQLTLE TIEKAVCSYF SITSNDLKGK 430 440 450 460 470 480 SKKKEIAVGR QIAMYLSKDM TDSSLKTIGL HFGGRDHSTV IHALNTIEKK IAASNEERKK 490 IEELRKRIEI MSM

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006470 Genomic DNA. Translation: AAM71250.1.
RefSeq	NP_660908.1. NC_002932.3.
3D structure databases
ProteinModelPortal	Q8KGG6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1006023.
GenomeReviews	Gene locus CT0002 in contig AE006470_GR.
KEGG	cte:CT0002.
NMPDR	fig|194439.1.peg.2.
PATRIC	21398105. VBIChlTep116050_0002.
TIGR	CT0002.
Phylogenomic databases
HOGENOM	HBG695666.
OMA	CHTLNAL.
ProtClustDB	PRK00149.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_0002-MONOMER.
Family and domain databases
HAMAP	MF_00377. DnaA_bact. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Gene3D	G3DSA:1.10.1750.10. DnaA_C. 1 hit.
KO	K02313.
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
SUPFAM	SSF48295. Trp_repress_rep. 1 hit.
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_CHLTE

Accession

Primary (citable) accession number: Q8KGG6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program