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Protein

NAD kinase

Gene

nadK

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorUniRule annotation1
Binding sitei145NADUniRule annotation1
Binding sitei163NADUniRule annotation1
Binding sitei165NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi66 – 67NADUniRule annotation2
Nucleotide bindingi134 – 135NADUniRule annotation2
Nucleotide bindingi176 – 181NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-86-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:CT0085
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001206101 – 283NAD kinaseAdd BLAST283

Proteomic databases

PRIDEiQ8KG83

Interactioni

Protein-protein interaction databases

STRINGi194439.CT0085

Structurei

3D structure databases

ProteinModelPortaliQ8KG83
SMRiQ8KG83
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000227222
KOiK00858
OMAiVNLGHVG
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KG83-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFAIFVNTT REKALELARE LTAWLDARSI DYVFDPQSAK ALGCGKWEEK
60 70 80 90 100
ADLSQHCDAF VALGGDGTLL LASHYSRSKP VVGINVGDLG FLTEFSPDEM
110 120 130 140 150
WVAMDHLVSG NYSIHTRSQL EATLESGESL TSLNDVIFEK GSAARRLPAF
160 170 180 190 200
TILLDDEMLG SYRADGIIIA TSTGSTAYSM SAGGPIIAPK SNVFVITPIC
210 220 230 240 250
PHMLTVRPIV ISDDKTIKIS VDSQSGEFPL KMDGIQKKLL APGEVVTVKK
260 270 280
SPHHINLVAN EKRNYCEILR KKLLWSHEHP TGE
Length:283
Mass (Da):30,989
Last modified:October 1, 2002 - v1
Checksum:iBD0615843D1A6A21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM71333.1
RefSeqiNP_660991.1, NC_002932.3
WP_010931779.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM71333; AAM71333; CT0085
GeneIDi1006506
KEGGicte:CT0085
PATRICifig|194439.7.peg.85

Similar proteinsi

Entry informationi

Entry nameiNADK_CHLTE
AccessioniPrimary (citable) accession number: Q8KG83
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 22, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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