ID   DXR_CHLTE               Reviewed;         382 AA.
AC   Q8KG43;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 39.
DE   RecName: Full=1-deoxy-D-xylulose 5-phosphate reductoisomerase;
DE            Short=DXP reductoisomerase;
DE            EC=1.1.1.267;
DE   AltName: Full=1-deoxyxylulose-5-phosphate reductoisomerase;
DE   AltName: Full=2-C-methyl-D-erythritol 4-phosphate synthase;
GN   Name=dxr; OrderedLocusNames=CT0125;
OS   Chlorobium tepidum.
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobaculum.
OX   NCBI_TaxID=1097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / TLS;
RX   MEDLINE=22103685; PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M.,
RA   Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F.,
RA   Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P.,
RA   Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B.,
RA   Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M.,
RA   Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a
RT   photosynthetic, anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
CC   -!- FUNCTION: Catalyzes the NADP-dependent rearrangement and reduction
CC       of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol
CC       4-phosphate (MEP) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 2-C-methyl-D-erythritol 4-phosphate + NADP(+)
CC       = 1-deoxy-D-xylulose 5-phosphate + NADPH.
CC   -!- COFACTOR: Divalent cation (By similarity).
CC   -!- PATHWAY: Isoprenoid biosynthesis; isopentenyl-PP biosynthesis via
CC       DXP pathway; isopentenyl-PP from 1-deoxy-D-xylulose 5-phosphate:
CC       step 1/6.
CC   -!- SIMILARITY: Belongs to the DXR family.
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DR   EMBL; AE006470; AAM71373.1; -; Genomic_DNA.
DR   RefSeq; NP_661031.1; -.
DR   HSSP; P45568; 1K5H.
DR   GeneID; 1006807; -.
DR   GenomeReviews; AE006470_GR; CT0125.
DR   KEGG; cte:CT0125; -.
DR   NMPDR; fig|194439.1.peg.125; -.
DR   TIGR; CT0125; -.
DR   HOGENOM; Q8KG43; -.
DR   OMA; Q8KG43; IHSMVEY.
DR   BioCyc; CTEP194439:CT_0125-MON; -.
DR   BRENDA; 1.1.1.267; 189605.
DR   GO; GO:0030604; F:1-deoxy-D-xylulose-5-phosphate reductoisome...; IEA:HAMAP.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00183; -; 1.
DR   InterPro; IPR003821; DXP_reductoisomerase.
DR   InterPro; IPR013644; DXP_reductoisomerase_C.
DR   InterPro; IPR013512; DXP_reductoisomerase_N.
DR   Pfam; PF08436; DXP_redisom_C; 1.
DR   Pfam; PF02670; DXP_reductoisom; 1.
DR   PIRSF; PIRSF006205; Dxp_reductismrs; 1.
DR   TIGRFAMs; TIGR00243; Dxr; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Isoprene biosynthesis; Metal-binding; NADP;
KW   Oxidoreductase.
FT   CHAIN         1    382       1-deoxy-D-xylulose 5-phosphate
FT                                reductoisomerase.
FT                                /FTId=PRO_0000163634.
FT   NP_BIND       7     36       NADP (By similarity).
FT   METAL       148    148       Divalent metal cation (By similarity).
FT   METAL       150    150       Divalent metal cation (By similarity).
FT   METAL       219    219       Divalent metal cation (By similarity).
FT   BINDING     123    123       Substrate (By similarity).
FT   BINDING     150    150       Substrate (By similarity).
FT   BINDING     174    174       Substrate (By similarity).
FT   BINDING     197    197       Substrate (By similarity).
FT   BINDING     219    219       Substrate (By similarity).
SQ   SEQUENCE   382 AA;  41344 MW;  4B42A8B6F36368CA CRC64;
     MKSLSILGST GSIGLSTLDV VRRHPERFSI AALAEGHDVE MLLKQIDEFR PSLVSVRDEA
     SRERLKGMLG DHKPEILCGL EGAAEVAAVD GADMVVSAIV GAAGLVPTVR AIEAGKDIAL
     ANKETLVVAG QLVSDLVKKH DVKLLPVDSE HSAIFQSLVG HRTEDIERII LTASGGPFRK
     TPAEELKNVG PEQALKHPQW SMGAKITIDS ATLMNKGLEV IEAHWLFDMP AEKIGVVVHP
     QSIIHSMVEY IDGCVIAQLG VPDMRAPIAY ALAWPERCET GIGKLDLTKV ATLTFEEPDM
     ERFPALRLAF DALKAGQTYP AVLNAANEIA VAAFLDKKIG FTDIAGTVDK TMQAHEAWTP
     ITLEEYLQAD KWARETARQL IG
//