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Protein

1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene

dxr

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).UniRule annotation

Catalytic activityi

2-C-methyl-D-erythritol 4-phosphate + NADP+ = 1-deoxy-D-xylulose 5-phosphate + NADPH.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: isopentenyl diphosphate biosynthesis via DXP pathway

This protein is involved in step 1 of the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate.UniRule annotation
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. 1-deoxy-D-xylulose 5-phosphate reductoisomerase (dxr)
  2. 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (ispD)
  3. 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase (ispE)
  4. 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (ispF)
  5. 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin) (ispG)
  6. 4-hydroxy-3-methylbut-2-enyl diphosphate reductase (ispH)
This subpathway is part of the pathway isopentenyl diphosphate biosynthesis via DXP pathway, which is itself part of Isoprenoid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate, the pathway isopentenyl diphosphate biosynthesis via DXP pathway and in Isoprenoid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei123SubstrateUniRule annotation1
Metal bindingi148Divalent metal cationUniRule annotation1
Metal bindingi150Divalent metal cationUniRule annotation1
Binding sitei150SubstrateUniRule annotation1
Binding sitei174SubstrateUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Metal bindingi219Divalent metal cationUniRule annotation1
Binding sitei219SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi7 – 36NADPUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandMetal-binding, NADP

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-126-MONOMER
UniPathwayiUPA00056; UER00092

Names & Taxonomyi

Protein namesi
Recommended name:
1-deoxy-D-xylulose 5-phosphate reductoisomeraseUniRule annotation (EC:1.1.1.267UniRule annotation)
Short name:
DXP reductoisomeraseUniRule annotation
Alternative name(s):
1-deoxyxylulose-5-phosphate reductoisomeraseUniRule annotation
2-C-methyl-D-erythritol 4-phosphate synthaseUniRule annotation
Gene namesi
Name:dxrUniRule annotation
Ordered Locus Names:CT0125
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001636341 – 3821-deoxy-D-xylulose 5-phosphate reductoisomeraseAdd BLAST382

Proteomic databases

PRIDEiQ8KG43

Interactioni

Protein-protein interaction databases

STRINGi194439.CT0125

Structurei

3D structure databases

ProteinModelPortaliQ8KG43
SMRiQ8KG43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DXR family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEA Bacteria
COG0743 LUCA
HOGENOMiHOG000007220
KOiK00099
OMAiDSEHFGL
OrthoDBiPOG091H0052

Family and domain databases

HAMAPiMF_00183 DXP_reductoisom, 1 hit
InterProiView protein in InterPro
IPR003821 DXP_reductoisomerase
IPR013644 DXP_reductoisomerase_C
IPR013512 DXP_reductoisomerase_N
IPR026877 DXPR_C
IPR036169 DXPR_C_sf
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR30525 PTHR30525, 1 hit
PfamiView protein in Pfam
PF08436 DXP_redisom_C, 1 hit
PF02670 DXP_reductoisom, 1 hit
PF13288 DXPR_C, 1 hit
PIRSFiPIRSF006205 Dxp_reductismrs, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
SSF69055 SSF69055, 1 hit
TIGRFAMsiTIGR00243 Dxr, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KG43-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSLSILGST GSIGLSTLDV VRRHPERFSI AALAEGHDVE MLLKQIDEFR
60 70 80 90 100
PSLVSVRDEA SRERLKGMLG DHKPEILCGL EGAAEVAAVD GADMVVSAIV
110 120 130 140 150
GAAGLVPTVR AIEAGKDIAL ANKETLVVAG QLVSDLVKKH DVKLLPVDSE
160 170 180 190 200
HSAIFQSLVG HRTEDIERII LTASGGPFRK TPAEELKNVG PEQALKHPQW
210 220 230 240 250
SMGAKITIDS ATLMNKGLEV IEAHWLFDMP AEKIGVVVHP QSIIHSMVEY
260 270 280 290 300
IDGCVIAQLG VPDMRAPIAY ALAWPERCET GIGKLDLTKV ATLTFEEPDM
310 320 330 340 350
ERFPALRLAF DALKAGQTYP AVLNAANEIA VAAFLDKKIG FTDIAGTVDK
360 370 380
TMQAHEAWTP ITLEEYLQAD KWARETARQL IG
Length:382
Mass (Da):41,344
Last modified:October 1, 2002 - v1
Checksum:i4B42A8B6F36368CA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM71373.1
RefSeqiNP_661031.1, NC_002932.3
WP_010931819.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM71373; AAM71373; CT0125
GeneIDi1006807
KEGGicte:CT0125
PATRICifig|194439.7.peg.123

Similar proteinsi

Entry informationi

Entry nameiDXR_CHLTE
AccessioniPrimary (citable) accession number: Q8KG43
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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