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Q8KG38

- GLMS_CHLTE

UniProt

Q8KG38 - GLMS_CHLTE

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei609 – 6091For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciCTEP194439:GHN0-132-MONOMER.

    Protein family/group databases

    MEROPSiC44.971.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:CT0130
    OrganismiChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS)
    Taxonomic identifieri194439 [NCBI]
    Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
    ProteomesiUP000001007: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 614613Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135320Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi194439.CT0130.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8KG38.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 223222Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini292 – 431140SIS 1UniRule annotationAdd
    BLAST
    Domaini463 – 604142SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258898.
    KOiK00820.
    OMAiPVTRRFM.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8KG38-1 [UniParc]FASTAAdd to Basket

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    MCGIIGYIGR REAAPLLLNG LKRLEYRGYD SAGMAVLNGS MKMLKKKGSV    50
    SNLEELLNVS GTVMLGATVG IAHTRWATHG DPSDRNAHPH MNVSGDIALI 100
    HNGIIENYSA LKQELMGEGY VFESDTDSEV LVHLIDRIWK NDSALGLEGA 150
    VRQALRHVEG AYGICVVSSR EPDKIVVARK GSPLVIGLGD GEFFIASDAA 200
    PIVEHTNKVV YLSDGEMAVV TRDSYTVKTI ENVEQQKRVT ELDFSLEKIE 250
    KGGFEHFMLK EIFEQPEVMR DVMRGRVRVE EGRVHLGGIH DYLDRLKQAK 300
    RIMICACGTS WHAGLIGEYL IEEFARIPVE VDYASEFRYR NPIVSSDDVV 350
    IVISQSGETA DTLAALRLAK EKGAMVMGIC NVVGSTIPRE TLCGMYTHAG 400
    PEVGVASTKA FTAQVIVLFM LAMALSKGRT ISQEEIKLNL RELAEVPDKV 450
    AWILEQNDAI KEIAVKLKDA RNALYLGRGY NFPVALEGAL KLKEISYIHA 500
    EGYPAAEMKH GPIALIDEDM PVIVIATRDN TYAKILSNIE EVRSRKGRVI 550
    AIASEGDREI ERLTEDVIYI PQASAAVLPL LTVIPLQLLS YHVATLRGCN 600
    VDRPRNLAKS VTVE 614
    Length:614
    Mass (Da):67,577
    Last modified:January 23, 2007 - v3
    Checksum:iA9B4195C3DC3F84F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM71378.1.
    RefSeqiNP_661036.1. NC_002932.3.
    WP_010931824.1. NC_002932.3.

    Genome annotation databases

    EnsemblBacteriaiAAM71378; AAM71378; CT0130.
    GeneIDi1006837.
    KEGGicte:CT0130.
    PATRICi21398359. VBIChlTep116050_0127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE006470 Genomic DNA. Translation: AAM71378.1 .
    RefSeqi NP_661036.1. NC_002932.3.
    WP_010931824.1. NC_002932.3.

    3D structure databases

    ProteinModelPortali Q8KG38.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 194439.CT0130.

    Protein family/group databases

    MEROPSi C44.971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM71378 ; AAM71378 ; CT0130 .
    GeneIDi 1006837.
    KEGGi cte:CT0130.
    PATRICi 21398359. VBIChlTep116050_0127.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258898.
    KOi K00820.
    OMAi PVTRRFM.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci CTEP194439:GHN0-132-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 49652 / DSM 12025 / TLS.

    Entry informationi

    Entry nameiGLMS_CHLTE
    AccessioniPrimary (citable) accession number: Q8KG38
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 25, 2002
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3