Q8KFP2 (Q8KFP2_CHLTE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lipid-A-disaccharide synthase, putative EMBL AAM71526.1
EC=2.4.1.182 EMBL AAM71526.1

Gene names

Name:	lpxB EMBL AAM71526.1
Ordered Locus Names:	CT0280

Organism

Chlorobium tepidum

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. SAAS SAAS003835
Catalytic activity	UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. SAAS SAAS003835
Pathway	Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. SAAS SAAS003835

Ontologies

Keywords
Biological process	Lipid A biosynthesis SAAS SAAS003835 Lipid synthesis
Molecular function	Glycosyltransferase SAAS SAAS003835 EMBL AAM71526.1 Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipid A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	lipid-A-disaccharide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8KFP2 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5DDDE3A99F274A28	FASTA	382	42,662
	10 20 30 40 50 60 MTCRRKLFVL AGEVSGDLHA AGPVRELLAA RPDTKVFGVG GRKLAELGAE LLYTTDQMSI 70 80 90 100 110 120 MGFVEVLKHA AFLRKAIREL KAAIVREKPD AALLIDYPGM NLHLAAFLKK QGVPVIYYIS 130 140 150 160 170 180 PQVWAWKERR VEKIRACVDR LLVIFDFEVE FYRRHGIDAE FVGNPVVEEL AELKFAPKPE 190 200 210 220 230 240 FLARMGIDSD ARIVGLLPGS RKQEIEKIFP EMLGAAKHIG EQGKTVFLLG RSPHIDPALY 250 260 270 280 290 300 DRYLREAGIE PLDCTSYEVM RYSDLELVTS GTATLESLCF AVPMVVLYKT SPLNYFIGKR 310 320 330 340 350 360 LVKLHNIALA NIVACGLLSE KQAVPELIQH EANAGNISRK VLEILCNDAV SSSMRRELRE 370 380 ARGRLSSDSP SRHVAAVLFE YL

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006470 Genomic DNA. Translation: AAM71526.1.
RefSeq	NP_661184.1. NC_002932.3.
3D structure databases
ProteinModelPortal	Q8KFP2.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1007837.
GenomeReviews	Gene locus CT0280 in contig AE006470_GR.
KEGG	cte:CT0280.
NMPDR	fig|194439.1.peg.278.
PATRIC	21398677. VBIChlTep116050_0272.
TIGR	CT0280.
Phylogenomic databases
HOGENOM	HBG584837.
OMA	PDFNLGL.
ProtClustDB	CLSK637261.
Family and domain databases
InterPro	IPR003835. Glyco_trans_19. [Graphical view]
KO	K00748.
Pfam	PF02684. LpxB. 1 hit. [Graphical view]
TIGRFAMs	TIGR00215. LpxB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q8KFP2_CHLTE

Accession

Primary (citable) accession number: Q8KFP2

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	December 14, 2011
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)