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Q8KFK6 (PUR9_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:CT0320
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192082

Sequences

Sequence LengthMass (Da)Tools
Q8KFK6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: EB17A1E65D679920

FASTA52356,743
        10         20         30         40         50         60 
MLDPVIKRAL VSVSDKTGIV DFCRELASMD VEIFSTGGTL KLLQGAGIVA QSISTITGFP 

        70         80         90        100        110        120 
EIMDGRVKTL HPKIHGGLLA VRDNAEHQKA ARENGIQFID LVVVNLYPFE ATIAKADVTF 

       130        140        150        160        170        180 
EEAIENIDIG GPSMLRSAAK NNESVTVVTD VADYATVLDE MRSNGGATTR ATRLTLAAKV 

       190        200        210        220        230        240 
YALTSRYDTA IAAYMAKAAG VKGAGDTMTL KLEKELSMRY GENPHQSAGL YKMDDGNGVR 

       250        260        270        280        290        300 
SFSAIFEKLH GKELSYNNML DIAAATGIIE EFRGEEPSVV IVKHTNPCGV AQAPTLCEAY 

       310        320        330        340        350        360 
RKAFSTDTQA PFGGIIAFNR PLDMETASAV NEIFTEILIA PAFEDGVLEM LMKKKDRRLV 

       370        380        390        400        410        420 
LQKQPLPKAG WEFKSTPFGM LVQERDSKTV APEELKVVTK RQPTAEELAD LMFAWKIVRH 

       430        440        450        460        470        480 
IKSNTILYVK NRQTFGVGAG QMSRVDSSKI ARWKASEVAL DLRGSVVASD AFFPFADGLL 

       490        500        510        520 
AAAEAGVTAV IQPGGSIRDN EVIEAADANN LAMVFTGMRH FKH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM71566.1.
RefSeqNP_661224.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KFK6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT0320.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM71566; AAM71566; CT0320.
GeneID1007981.
KEGGcte:CT0320.
PATRIC21398757. VBIChlTep116050_0310.

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMARAFKTDP.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-338-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_CHLTE
AccessionPrimary (citable) accession number: Q8KFK6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways