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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-347-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Synonyms:bacA, upk
Ordered Locus Names:CT0329
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalUniRule annotationAdd BLAST21
Transmembranei40 – 60HelicalUniRule annotationAdd BLAST21
Transmembranei89 – 109HelicalUniRule annotationAdd BLAST21
Transmembranei112 – 132HelicalUniRule annotationAdd BLAST21
Transmembranei153 – 173HelicalUniRule annotationAdd BLAST21
Transmembranei196 – 216HelicalUniRule annotationAdd BLAST21
Transmembranei228 – 248HelicalUniRule annotationAdd BLAST21
Transmembranei258 – 278HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001511311 – 282Undecaprenyl-diphosphataseAdd BLAST282

Interactioni

Protein-protein interaction databases

STRINGi194439.CT0329

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105DWR Bacteria
COG1968 LUCA
HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW
OrthoDBiPOG091H00ZR

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KFJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFQAIILG IIQGLTEFLP ISSSAHLRIV PALMGWGDPG AAFTAIIQIG
60 70 80 90 100
TLAAVLIYFA KDIVSISGAV ISGLVKGKPL GTDEARTGWM IAVGTIPIVV
110 120 130 140 150
FGLTFKHEIE TVLRSLYIVS ASMIGLALVL VVAEKHTANR ARDGRRGKSI
160 170 180 190 200
NELSWTDAII IGLAQAMALI PGSSRSGVTI TGGLFRNLDR ETAARFSFLL
210 220 230 240 250
SLPSVFAAGM LELYQTRQEI MSSTHNMLNL AVATIAAFIF GYLSIAFLLN
260 270 280
YLKRHTTGIF IAYRLILGIG LIVMIGTGHL LP
Length:282
Mass (Da):30,197
Last modified:October 1, 2002 - v1
Checksum:i8231A028E2C17C19
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM71575.1
RefSeqiNP_661233.1, NC_002932.3
WP_010932021.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM71575; AAM71575; CT0329
GeneIDi1007991
KEGGicte:CT0329
PATRICifig|194439.7.peg.319

Similar proteinsi

Entry informationi

Entry nameiUPPP_CHLTE
AccessioniPrimary (citable) accession number: Q8KFJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health