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Q8KEX2 (NADE_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
NH(3)-dependent NAD(+) synthetase

EC=6.3.1.5
Gene names
Name:nadE
Ordered Locus Names:CT0560
OrganismChlorobium tepidum
Taxonomic identifier1097 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+. HAMAP MF_00193

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1. HAMAP MF_00193

Sequence similarities

Belongs to the NAD synthetase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 277277NH(3)-dependent NAD(+) synthetase HAMAP MF_00193
PRO_0000152163

Regions

Nucleotide binding36 – 438ATP By similarity

Sites

Active site381 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KEX2 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CBEBD73BE5A462E2

FASTA27731,125
        10         20         30         40         50         60 
MKPQNLHFDY GLVEAILVPF IRNEIRKFGF GSVVLGLSGG IDSAVVCELA VRALGVENVL 

        70         80         90        100        110        120 
ALMMPYKTSS QESLDHAELM VDRLGIRYEI MPVTEVVDAF FATRPDASRL RRGNVMARSR 

       130        140        150        160        170        180 
MLCLYDVSAR DGCLVLGTSN KTELMLGYGT MFGDMASAVN PIGDLYKTQI FGLARHLGIP 

       190        200        210        220        230        240 
APLIDKPPSA DLWEGQSDEA DLGFSYEEVD QLLYMMLEER MDRDAILAEG IDSAFYQRVR 

       250        260        270 
SMVVRNQYKR MMPVIAKLSS RTPGIDFRYA RDWQEVR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM71802.1.
RefSeqNP_661460.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KEX2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1006143.
GenomeReviewsGene locus CT0560 in contig AE006470_GR.
KEGGcte:CT0560.
NMPDRfig|194439.1.peg.554.
PATRIC21399201. VBIChlTep116050_0524.
TIGRCT0560.

Phylogenomic databases

HOGENOMHBG351567.
OMAYDISARD.
ProtClustDBPRK13980.

Enzyme and pathway databases

BioCycCTEP194439:CT_0560-MONOMER.

Family and domain databases

HAMAPMF_00193. NadE.
[Tree]
InterProIPR022310. NAD/GMP_synthase.
IPR003694. NAD_synthase.
IPR022926. NH(3)-dep_NAD(+)_synth.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
Gene3DG3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KOK01916.
PfamPF02540. NAD_synthase. 1 hit.
[Graphical view]
TIGRFAMsTIGR00552. NadE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADE_CHLTE
AccessionPrimary (citable) accession number: Q8KEX2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families