Q8KES3 (Q8KES3_CHLTE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Sepiapterin reductase EMBL AAM71851.1

Gene names

Ordered Locus Names:

CT0609

Organism

Chlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]

Taxonomic identifier

194439 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Bacteroidetes/Chlorobi group › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum › Chlorobaculum tepidum

Protein attributes

Sequence length	244 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family. RuleBase RU000363

Ontologies

Keywords
Ligand	NADP PDB 2BD0 Nucleotide-binding PDB 2BD0
Technical term	3D-structure PDB 2BD0 Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	oxidation-reduction process Inferred from electronic annotation. Source: GOC
Molecular_function	nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW oxidoreductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	12 – 14	3	NADP PDB 2BD0
	Nucleotide binding	40 – 42	3	NADP PDB 2BD0
	Nucleotide binding	66 – 67	2	NADP PDB 2BD0
	Nucleotide binding	191 – 196	6	NADP PDB 2BD0
Sites
	Binding site	93	1	NADP; via carbonyl oxygen PDB 2BD0
	Binding site	116	1	NADP PDB 2BD0
	Binding site	158	1	NADP PDB 2BD0
	Binding site	162	1	NADP PDB 2BD0

Sequences

	Sequence		Length	Mass (Da)
	Q8KES3 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 754CE7BC0363D9DA	FASTA	244	27,114
	10 20 30 40 50 60 MKHILLITGA GKGIGRAIAL EFARAARHHP DFEPVLVLSS RTAADLEKIS LECRAEGALT 70 80 90 100 110 120 DTITADISDM ADVRRLTTHI VERYGHIDCL VNNAGVGRFG ALSDLTEEDF DYTMNTNLKG 130 140 150 160 170 180 TFFLTQALFA LMERQHSGHI FFITSVAATK AFRHSSIYCM SKFGQRGLVE TMRLYARKCN 190 200 210 220 230 240 VRITDVQPGA VYTPMWGKVD DEMQALMMMP EDIAAPVVQA YLQPSRTVVE EIILRPTSGD IQDD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.
[2]	"Structure of Chlorobium tepidum sepiapterin reductase complex reveals the novel substrate binding mode for stereospecific production of L-threo-tetrahydrobiopterin." Supangat S., Seo K.H., Choi Y.K., Park Y.S., Son D., Han C.D., Lee K.H. J. Biol. Chem. 281:2249-2256(2006) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) IN COMPLEX WITH NADP.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE006470 Genomic DNA. Translation: AAM71851.1.

RefSeq

NP_661509.1. NC_002932.3.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2BD0	X-ray	1.70	A/B/C/D	1-244	[»]

ProteinModelPortal

Q8KES3.

SMR

Q8KES3. Positions 2-241.

ModBase

Search...

Protein-protein interaction databases

STRING

194439.CT0609.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAM71851; AAM71851; CT0609.

GeneID

1006254.

KEGG

cte:CT0609.

PATRIC

21399285. VBIChlTep116050_0566.

Phylogenomic databases

OMA

IFFITSV.

ProtClustDB

CLSK637393.

Enzyme and pathway databases

BioCyc

CTEP194439:GHN0-634-MONOMER.
MetaCyc:MONOMER-13404.

Family and domain databases

Gene3D

3.40.50.720. 1 hit.

InterPro

IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]

Pfam

PF00106. adh_short. 1 hit.
[Graphical view]

PRINTS

PR00081. GDHRDH.
PR00080. SDRFAMILY.

ProtoNet

Search...

Other

EvolutionaryTrace

Q8KES3.

Entry information

Entry name

Q8KES3_CHLTE

Accession

Primary (citable) accession number: Q8KES3

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 29, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)