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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB-1), Tryptophan synthase beta chain (trpB-2), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-743-MONOMER
UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:CT0718
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543541 – 221N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST221

Proteomic databases

PRIDEiQ8KEH1

Interactioni

Protein-protein interaction databases

STRINGi194439.CT0718

Structurei

3D structure databases

ProteinModelPortaliQ8KEH1
SMRiQ8KEH1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZGB Bacteria
COG0135 LUCA
HOGENOMiHOG000161598
KOiK01817
OMAiFYAKSPR
OrthoDBiPOG091H01PA

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KEH1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKIKICGIT RAQDALEAAL AGADALGFNF SRKSPRRIDA ETARSIIAGL
60 70 80 90 100
PPLVTPVGVF VEQSPEEIND ICRHCGLLVA QLHSDDYDAE KTLQIKGVRV
110 120 130 140 150
IRVFRPSPGF EVSQVRKFTE KTGCRSFLFD AYSPAMAGGT GQSIEAQTAG
160 170 180 190 200
SLFDETRDFS WALLAGGLKP ENVGDAVTLI RPWGVDTASG VESGPGIKDA
210 220
LKIRQFVEAV RKADRSLTNC C
Length:221
Mass (Da):23,801
Last modified:October 1, 2002 - v1
Checksum:i75C1C6D353E36BCE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM71955.1
RefSeqiNP_661613.1, NC_002932.3
WP_010932400.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM71955; AAM71955; CT0718
GeneIDi1006346
KEGGicte:CT0718
PATRICifig|194439.7.peg.658

Similar proteinsi

Entry informationi

Entry nameiTRPF_CHLTE
AccessioniPrimary (citable) accession number: Q8KEH1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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