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Q8KEA8 (GCH1_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase 1

EC=3.5.4.16
Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I
Gene names
Name:folE
Ordered Locus Names:CT0781
OrganismChlorobium tepidum (strain ATCC 49652 / DSM 12025 / TLS) [Reference proteome] [HAMAP]
Taxonomic identifier194439 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length224 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Subunit structure

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Sequence similarities

Belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 224224GTP cyclohydrolase 1 HAMAP-Rule MF_00223
PRO_0000119396

Sites

Metal binding1141Zinc By similarity
Metal binding1171Zinc By similarity
Metal binding1851Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KEA8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: F2E4A9B7157D7807

FASTA22425,368
        10         20         30         40         50         60 
MKQEKTVSPT VENNRSAESR LSQCDLDECF DESHDRDEEV LGSMTDAVYS LLKGVGEDPE 

        70         80         90        100        110        120 
REGLLLTPER VAKSLRFLTK GYRQDPEQLL KKAVFTESYD EMVLVKDIDI YSMCEHHMLP 

       130        140        150        160        170        180 
FFGKAHVAYI PDGKIVGLSK IPRVVEVFAR RLQVQERLTQ QIRDAIQNVL NPRGVAVVIE 

       190        200        210        220 
ATHMCMVMRG VEKQNAVTTT SAMSGDFMTS QSTRSEFLRL IGNH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72018.1.
RefSeqNP_661676.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KEA8.
SMRQ8KEA8. Positions 52-218.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING194439.CT0781.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM72018; AAM72018; CT0781.
GeneID1006416.
KEGGcte:CT0781.
PATRIC21399591. VBIChlTep116050_0711.

Phylogenomic databases

eggNOGCOG0302.
HOGENOMHOG000221222.
KOK01495.
OMAVIVVTEC.
OrthoDBEOG6XHC8G.
ProtClustDBPRK09347.

Enzyme and pathway databases

BioCycCTEP194439:GHN0-814-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_00223. FolE.
InterProIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsTIGR00063. folE. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH1_CHLTE
AccessionPrimary (citable) accession number: Q8KEA8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways