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Protein

Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase

Gene

cobT

Organism
Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).UniRule annotation

Catalytic activityi

Beta-nicotinate D-ribonucleotide + 5,6-dimethylbenzimidazole = nicotinate + alpha-ribazole 5'-phosphate.UniRule annotation

Pathwayi: alpha-ribazole biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase (cobT)
  2. no protein annotated in this organism
This subpathway is part of the pathway alpha-ribazole biosynthesis, which is itself part of Nucleoside biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes alpha-ribazole from 5,6-dimethylbenzimidazole, the pathway alpha-ribazole biosynthesis and in Nucleoside biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei319Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCobalamin biosynthesis

Enzyme and pathway databases

BioCyciCTEP194439:G1FZE-982-MONOMER
UniPathwayiUPA00061; UER00516

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseUniRule annotation (EC:2.4.2.21UniRule annotation)
Short name:
NN:DBI PRTUniRule annotation
Alternative name(s):
N(1)-alpha-phosphoribosyltransferaseUniRule annotation
Gene namesi
Name:cobTUniRule annotation
Ordered Locus Names:CT0946
OrganismiChlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) (Chlorobium tepidum)
Taxonomic identifieri194439 [NCBI]
Taxonomic lineageiBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum
Proteomesi
  • UP000001007 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001670401 – 353Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferaseAdd BLAST353

Proteomic databases

PRIDEiQ8KDU8

Interactioni

Protein-protein interaction databases

STRINGi194439.CT0946

Structurei

3D structure databases

ProteinModelPortaliQ8KDU8
SMRiQ8KDU8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CobT family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CUP Bacteria
COG2038 LUCA
HOGENOMiHOG000263500
KOiK00768
OMAiATFGGFE
OrthoDBiPOG091H0031

Family and domain databases

CDDicd02439 DMB-PRT_CobT, 1 hit
Gene3Di1.10.1610.10, 2 hits
HAMAPiMF_00230 CobT, 1 hit
InterProiView protein in InterPro
IPR003200 Nict_dMeBzImd_PRibTrfase-like
IPR023195 Nict_dMeBzImd_PRibTrfase_N
IPR017846 Nict_dMeBzImd_PRibTrfase_pro
IPR036087 Nict_dMeBzImd_PRibTrfase_sf
PfamiView protein in Pfam
PF02277 DBI_PRT, 1 hit
SUPFAMiSSF52733 SSF52733, 1 hit
TIGRFAMsiTIGR03160 cobT_DBIPRT, 1 hit

Sequencei

Sequence statusi: Complete.

Q8KDU8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDRFQQLLA SIKPVDMNLT STVKAHLDDL TKPQGSLGRL EEIVMKYCIA
60 70 80 90 100
TGTTKPSLSK KKVFCFAGDH GVAAEGVSAF PAEVTPQMVY NMLGGGAAIN
110 120 130 140 150
VLSRHAGADL EVVDMGVNHD FAEHPMLRRC KVKHGSANMA EGPAMSIEET
160 170 180 190 200
LQAIMAGAEL AIEARNQGYE LLATGEMGIA NTTPATALYA TLLGLPVEAI
210 220 230 240 250
TGRGTGIDDE RLHHKVAVIE KAIEVNRANL ATPLEVLAAL GGFEIAGICG
260 270 280 290 300
LILGAASVGM PVVVDGFISS SAAVCAIKLS CTVSDYLFFS HLSNEQGHRA
310 320 330 340 350
VMQKLGARPI LDLDLRLGEG TGAAMAMQVI EASVKIYNEM ATFSSAGVSG

KND
Length:353
Mass (Da):37,055
Last modified:October 1, 2002 - v1
Checksum:iBDC7E1703CB81CD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006470 Genomic DNA Translation: AAM72181.1
RefSeqiNP_661839.1, NC_002932.3
WP_010932626.1, NC_002932.3

Genome annotation databases

EnsemblBacteriaiAAM72181; AAM72181; CT0946
GeneIDi1007096
KEGGicte:CT0946
PATRICifig|194439.7.peg.857

Similar proteinsi

Entry informationi

Entry nameiCOBT_CHLTE
AccessioniPrimary (citable) accession number: Q8KDU8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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