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Q8KDT8 (HPPA_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
K(+)-insensitive pyrophosphate-energized proton pump
EC=3.6.1.1
Alternative name(s):
Membrane-bound proton-translocating pyrophosphatase
Pyrophosphate-energized inorganic pyrophosphatase
Short name=H(+)-PPase
Gene names
Name:hppA
Ordered Locus Names:CT0956
OrganismChlorobium tepidum
Taxonomic identifier1097 [NCBI]
Taxonomic lineageBacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force By similarity. HAMAP MF_01129

Catalytic activity

Diphosphate + H2O = 2 phosphate. HAMAP MF_01129

Cofactor

Magnesium By similarity. HAMAP MF_01129

Subunit structure

Homodimer By similarity. HAMAP MF_01129

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_01129.

Sequence similarities

Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. [View classification]

Ontologies

Keywords
   Biological processHydrogen ion transport
Ion transport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   LigandMagnesium
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processproton transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionhydrogen-translocating pyrophosphatase activity

Inferred from electronic annotation. Source: InterPro

inorganic diphosphatase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750K(+)-insensitive pyrophosphate-energized proton pump HAMAP MF_01129
PRO_0000217015

Regions

Transmembrane1 – 2121Helical; Potential
Transmembrane51 – 7121Helical; Potential
Transmembrane78 – 9821Helical; Potential
Transmembrane133 – 15321Helical; Potential
Transmembrane161 – 18121Helical; Potential
Transmembrane227 – 24721Helical; Potential
Transmembrane257 – 27721Helical; Potential
Transmembrane301 – 32121Helical; Potential
Transmembrane327 – 34721Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane420 – 44021Helical; Potential
Transmembrane503 – 52321Helical; Potential
Transmembrane538 – 55821Helical; Potential
Transmembrane607 – 62721Helical; Potential
Transmembrane629 – 64921Helical; Potential
Transmembrane694 – 71421Helical; Potential
Transmembrane716 – 73621Helical; Potential

Sites

Site4971Determinant of potassium independence By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KDT8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 9B415594BCDC377D

FASTA75080,370
        10         20         30         40         50         60 
MYGLVVCLFG MIFGLIQYQG INKLPVHAAM KEISDLIYET CKTYLITQGK FIIILWALVA 

        70         80         90        100        110        120 
AIIVAYFGGL NHLAPDKVVF ILACSLLGIA GSYTVAWFGM RINTFANSRT AFASLGGKPF 

       130        140        150        160        170        180 
PTYAIPLRAG MSIGMLLISI ELFAMLCILL FIPVDYAGPC FIGFAIGESL GASVLRIAGG 

       190        200        210        220        230        240 
IFTKIADIGS DLMKIVFKIK EDDARNPGVI ADCTGDNAGD SVGPTADGFE TYGVTGVALI 

       250        260        270        280        290        300 
SFILLAIKDP SIQVSLLVWI FAMRLVMIVA SAVSYWVNDA LAKMKYGNAD EMNFEKPLIT 

       310        320        330        340        350        360 
LVWLTSIVSI VLTYIASYML IAQLGDGTMW WKLASIITCG TIAGALIPEL VDRFTSTECA 

       370        380        390        400        410        420 
FVRNVVQCSK EGGAALNILS GLVAGNFSAY WMGLAIIVLM GAAFGFSTLG LDVMMLAPSV 

       430        440        450        460        470        480 
FAFGLVAFGF LSMGPVTIAV DSYGPVTDNA QSVYELSLIE TLPNISNSIE SEFGFKPDFE 

       490        500        510        520        530        540 
NAKRYLEAND GAGNTFKATA KPVLIGTAVV GSTTMIFSII MILTGGLADT GAIAKLSILW 

       550        560        570        580        590        600 
PPFLLGLLMG GAVIYWFTGA SMNAVTTGAY YAVAFIKKNI KLDGVTKAST EDSKKVVEIC 

       610        620        630        640        650        660 
TRFAQKGMIN LFLTIFFSTL AFACLESYLF IGYLISIALF GLYQAIFMAN AGGAWDNAKK 

       670        680        690        700        710        720 
VVETELHAKG TELHDASVVG DTVGDPFKDT SSVALNPIIK FTTLFGLLAI ELAIKLPTTI 

       730        740        750 
SVSLAVVFFL LSLVFVHRSF FSMRIAVDKD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE006470 Genomic DNA. Translation: AAM72191.1.
RefSeqNP_661849.1. NC_002932.3.

3D structure databases

ModBaseSearch...

Proteomic databases

PRIDEQ8KDT8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1007080.
GenomeReviewsGene locus CT0956 in contig AE006470_GR.
KEGGcte:CT0956.
NMPDRfig|194439.1.peg.943.
PATRIC21399907. VBIChlTep116050_0866.
TIGRCT0956.

Phylogenomic databases

HOGENOMHBG309781.
OMAGSDLMKI.
ProtClustDBPRK00733.

Enzyme and pathway databases

BioCycCTEP194439:CT_0956-MONOMER.

Family and domain databases

HAMAPMF_01129. PPase-energized_pump.
[Tree]
InterProIPR004131. PPase-energised_H-pump.
[Graphical view]
KOK01507.
PfamPF03030. H_PPase. 1 hit.
[Graphical view]
PIRSFPIRSF001265. H+-PPase. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHPPA_CHLTE
AccessionPrimary (citable) accession number: Q8KDT8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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