ID   PUR7_CHLTE              Reviewed;         235 AA.
AC   Q8KDT4;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Phosphoribosylaminoimidazole-succinocarboxamide synthase;
DE            EC=6.3.2.6;
DE   AltName: Full=SAICAR synthetase;
GN   Name=purC; OrderedLocusNames=CT0960;
OS   Chlorobium tepidum.
OC   Bacteria; Chlorobi; Chlorobia; Chlorobiales; Chlorobiaceae;
OC   Chlorobaculum.
OX   NCBI_TaxID=1097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49652 / DSM 12025 / TLS;
RX   MEDLINE=22103685; PubMed=12093901; DOI=10.1073/pnas.132181499;
RA   Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M.,
RA   Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H.,
RA   Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F.,
RA   Holt I.E., Umayam L.A., Mason T.M., Brenner M., Shea T.P.,
RA   Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B.,
RA   Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M.,
RA   Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M.;
RT   "The complete genome sequence of Chlorobium tepidum TLS, a
RT   photosynthetic, anaerobic, green-sulfur bacterium.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002).
CC   -!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-
CC       ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate +
CC       (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
CC       carboxamido)succinate.
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
CC       5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from N(2)-
CC       formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 4/5.
CC   -!- SIMILARITY: Belongs to the SAICAR synthetase family.
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DR   EMBL; AE006470; AAM72195.1; -; Genomic_DNA.
DR   RefSeq; NP_661853.1; -.
DR   HSSP; Q9X0X0; 1KUT.
DR   GeneID; 1007076; -.
DR   GenomeReviews; AE006470_GR; CT0960.
DR   KEGG; cte:CT0960; -.
DR   NMPDR; fig|194439.1.peg.947; -.
DR   TIGR; CT0960; -.
DR   HOGENOM; Q8KDT4; -.
DR   OMA; Q8KDT4; TAFNAQK.
DR   BioCyc; CTEP194439:CT_0960-MON; -.
DR   BRENDA; 6.3.2.6; 189605.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004639; F:phosphoribosylaminoimidazolesuccinocarboxam...; IEA:HAMAP.
DR   GO; GO:0006164; P:purine nucleotide biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00137; -; 1.
DR   InterPro; IPR013816; ATP_grasp_subdomain_2.
DR   InterPro; IPR001636; SAICAR_synt.
DR   InterPro; IPR018236; SAICAR_synthetase_CS.
DR   Gene3D; G3DSA:3.30.470.20; ATP_grasp_subdomain_2; 1.
DR   PANTHER; PTHR11609; SAICAR_synt; 1.
DR   Pfam; PF01259; SAICAR_synt; 1.
DR   ProDom; PD003043; SAICAR_synt; 1.
DR   TIGRFAMs; TIGR00081; purC; 1.
DR   PROSITE; PS01057; SAICAR_SYNTHETASE_1; 1.
DR   PROSITE; PS01058; SAICAR_SYNTHETASE_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Ligase; Nucleotide-binding;
KW   Purine biosynthesis.
FT   CHAIN         1    235       Phosphoribosylaminoimidazole-
FT                                succinocarboxamide synthase.
FT                                /FTId=PRO_0000100815.
SQ   SEQUENCE   235 AA;  26541 MW;  807AD30CD101BF4F CRC64;
     MNKVTLLHEG KAKKVWQTDN PDLIIQEFKD DATAFNNKKK GSIADKGVTN NAIASRLFTM
     LGENGIPTHF VGKLNDRDML CKKLDILLIE VVTRNIAAGS LVRRYGFKEG TVLSKPIVEL
     YLKNDELDDP LMNEDHAVAL GLGTCEEVAH LKAMAKKINS LLVPWFAERK LRLVDFKLEF
     GRHKGEILLG DEISPDTCRF WDAESGEKLD KDRFRLDLGG VEDAYSEVKR RVLEQ
//