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Q8KDK5 (PYRC_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroorotase

Short name=DHOase
EC=3.5.2.3
Gene names
Name:pyrC
Ordered Locus Names:CT1042
OrganismChlorobium tepidum
Taxonomic identifier1097 [NCBI]
Taxonomic lineageBacteriaChlorobiChlorobiaChlorobialesChlorobiaceaeChlorobaculum

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00220_B

Cofactor

Binds 2 zinc ions per subunit By similarity. HAMAP MF_00220_B

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3. HAMAP MF_00220_B

Subunit structure

Homodimer By similarity. HAMAP MF_00220_B

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily.

Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Dihydroorotase HAMAP MF_00220_B
PRO_0000147230

Sites

Metal binding651Zinc 1 By similarity
Metal binding671Zinc 1 By similarity
Metal binding1831Zinc 2 By similarity
Metal binding2461Zinc 2 By similarity
Metal binding3211Zinc 1 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8KDK5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 71FDCBCA995B7183

FASTA43947,039
        10         20         30         40         50         60 
MSTLFLNARL LNPAENLDTV GSIKIGDDGL IEAVATGGES IPAKAEDNVI DLAGKVLAPG 

        70         80         90        100        110        120 
LFDMHCHFRE PGQEYKETLE TGSAAAVAGG FTGVALMPNT RPVIDSPLGV AYIRHHSAGL 

       130        140        150        160        170        180 
PIDLEVIGAM TVESRGEALA PYGKYASYSV KAVSDDGTAI QSSQIMRLAI EYAANFDLLL 

       190        200        210        220        230        240 
IQHAEDKHLT AGGIMNDGAV SAMLGLKGIP EVAEPIMIAR DLQLIAWLKK HKLNGAVAEP 

       250        260        270        280        290        300 
RYHVAHISTA ESVALVRKAK AAGLKVTCEV TPHHFTLTEH DLSSSIEKGN FIMKPPLASV 

       310        320        330        340        350        360 
ENRDALIEGL RDGTIDAIAT DHAPHAKHEK ECPPDQAAFG IIGLETSLGL TITELVDKGV 

       370        380        390        400        410        420 
ITLSQAIELL STNPRRIMGL ETILFRAGRK ANLTIIDPDC EWIVSESDFG SKSRNTPFMG 

       430 
RKLKGRALGI YHNSKLIMR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE006470 Genomic DNA. Translation: AAM72275.1.
RefSeqNP_661933.1. NC_002932.3.

3D structure databases

ProteinModelPortalQ8KDK5.
ModBaseSearch...

Proteomic databases

PRIDEQ8KDK5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1006973.
GenomeReviewsGene locus CT1042 in contig AE006470_GR.
KEGGcte:CT1042.
NMPDRfig|194439.1.peg.1027.
PATRIC21400077. VBIChlTep116050_0950.
TIGRCT1042.

Phylogenomic databases

HOGENOMHBG724623.
OMASHHQPHE.
ProtClustDBPRK09357.

Enzyme and pathway databases

BioCycCTEP194439:CT_1042-MONOMER.

Family and domain databases

HAMAPMF_00220_B. PyrC_type2_B.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01465.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR00857. PyrC_multi. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. False negative.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePYRC_CHLTE
AccessionPrimary (citable) accession number: Q8KDK5
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families