Q8KDJ5 (ARLY_CHLTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	CT1055

Organism

Chlorobium tepidum

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	463 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm By similarity HAMAP MF_00006.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 463	463	Argininosuccinate lyase HAMAP MF_00006		PRO_0000137757

Sequences

	Sequence		Length	Mass (Da)
	Q8KDJ5 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 9623F7BA92A84AF2	FASTA	463	51,897
	10 20 30 40 50 60 MSDQSNQKEL LWQSRFSEPF DREALKFSSS VHVDGLLYRE DIQGSIAHAT MLGEQGIISK 70 80 90 100 110 120 EEAGQIVTGL KAVEKEIESG ELTPVWEDED IHTVIENRLK ELIGPTAGKL HSGRSRNDQV 130 140 150 160 170 180 ATDTRLYLRR NIDRIGELLK AMQSTLLDKA EQYKHTIMFG YTHLQRAQPI SAGHYYMAWH 190 200 210 220 230 240 SMFGRDAQRL ADLRKRANIS PLGAAAFAGS TLPLDPARSA ELLEFDGVFT NSIDAVSDRD 250 260 270 280 290 300 LVIEFVSACS MIMMHLSRFS EDVILWSSAE FNYLSISDAF ATGSSIMPQK KNADIAELVR 310 320 330 340 350 360 GKTGRVYGNL MNLLTIMKGL PLSYNRDMQE DKPPLFDTAE TTASSLSVFR RMIEKTWLNE 370 380 390 400 410 420 ERLARLTAED LSLATEIAEY LVKKQIPFRD AHRITGKIVA YAIEQGKTLP TISLDEYRTF 430 440 450 460 SEAFDEGIYD DLKPDASVNS KKTAGSCSFK SVEEQIARAK AAR

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE006470 Genomic DNA. Translation: AAM72288.1.
RefSeq	NP_661946.1. NC_002932.3.
3D structure databases
ProteinModelPortal	Q8KDJ5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1006960.
GenomeReviews	Gene locus CT1055 in contig AE006470_GR.
KEGG	cte:CT1055.
NMPDR	fig|194439.1.peg.1040.
PATRIC	21400099. VBIChlTep116050_0961.
TIGR	CT1055.
Phylogenomic databases
HOGENOM	HBG539632.
OMA	EDIHTVI.
ProtClustDB	PRK00855.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_1055-MONOMER.
Family and domain databases
HAMAP	MF_00006. Arg_succ_lyase. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
KO	K01755.
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_CHLTE

Accession

Primary (citable) accession number: Q8KDJ5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program