Reviewed, UniProtKB/Swiss-Prot Q8KDE3 (ARGC_CHLTE)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	CT1109

Organism

Chlorobium tepidum [Complete proteome] [HAMAP]

Taxonomic identifier

1097 [NCBI]

Taxonomic lineage

Bacteria › Chlorobi › Chlorobia › Chlorobiales › Chlorobiaceae › Chlorobaculum

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 341	341	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112395
Sites
	Active site	151	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8KDE3-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: EF684FBDD4075F3D	FASTA	341	36,613
	10 20 30 40 50 60 MNHIPMQNKK VTVSVIGASG YSGAELVKLL MKHPGIVIEE LYAHTQAGKR FTELYPSIPC 70 80 90 100 110 120 DKTFQTYAGQ TNSDVYLLAL PHGEALQLVP GIVAAGKKVI DLSGDFRLKN TAEHKRFYGG 130 140 150 160 170 180 DKSAEDVLQY GMPELFRDEI AGSTAISNPG CYATSIILGL APLFLGGMAG LDVESVNVTA 190 200 210 220 230 240 VSGISGAGRS AKLELSFSEM SGNMRAYKVG KHQHTPEIMQ TLGTSVTDPS FRFVFTPMIA 250 260 270 280 290 300 PYVRGIYSVL NVRLASPVAM EPVRELYAGF YANAPFVRLR DGVTEVSHVA YTNFCDISLA 310 320 330 340 FESDGSLVII TAIDNLVKGA AGQAVQNMNL MLGFGETTAL L

References

[1]

"The complete genome sequence of Chlorobium tepidum TLS, a photosynthetic, anaerobic, green-sulfur bacterium." Eisen J.A., Nelson K.E., Paulsen I.T., Heidelberg J.F., Wu M., Dodson R.J., DeBoy R.T., Gwinn M.L., Nelson W.C., Haft D.H., Hickey E.K., Peterson J.D., Durkin A.S., Kolonay J.F., Yang F., Holt I.E., Umayam L.A., Mason T.M. , Brenner M., Shea T.P., Parksey D.S., Nierman W.C., Feldblyum T.V., Hansen C.L., Craven M.B., Radune D., Vamathevan J.J., Khouri H.M., White O., Gruber T.M., Ketchum K.A., Venter J.C., Tettelin H., Bryant D.A., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:9509-9514(2002) [PubMed: 12093901] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 49652 / DSM 12025 / TLS.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006470 Genomic DNA. Translation: AAM72342.1.
RefSeq	NP_662000.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1006899.
GenomeReviews	Gene locus CT1109 in contig AE006470_GR.
KEGG	cte:CT1109.
NMPDR	fig|194439.1.peg.1094.
TIGR	CT1109.
Phylogenomic databases
HOGENOM	Q8KDE3.
OMA	Q8KDE3. VCRIAVH.
Enzyme and pathway databases
BioCyc	CTEP194439:CT_1109-MON.
BRENDA	1.2.1.38. 189605.
Family and domain databases
HAMAP	MF_00150. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_C. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
ProDom	PD003765. AGPR_act_site. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_CHLTE

Accession

Primary (citable) accession number: Q8KDE3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)